Structural and functional studies of polyketide synthases

Autor: Drulyte, Ieva

Polyketides, natural products produced by multi-domain polyketide synthases (PKSs), have proven to be excellent starting points for drug discovery. Rational engineering of PKSs holds much promise for the generation of novel polyketide pharmaceuticals

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766422

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Tomo Live: an on‐the‐fly reconstruction pipeline to judge data quality for cryo‐electron tomography workflows.

Autor: Comet, Maxime, Dijkman, Patricia M., Boer Iwema, Reint, Franke, Tilman, Masiulis, Simonas, Schampers, Ruud, Raschdorf, Oliver, Grollios, Fanis, Pryor, Edward E., Drulyte, Ieva

Publikováno v: Acta Crystallographica: Section D, Structural Biology; Apr2024, Vol. 80 Issue 4, p247-258, 12p

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

Autor: Du, Wenjuan, Hurdiss, Daniel L, Drabek, Dubravka, Mykytyn, Anna Z, Kaiser, Franziska K, González-Hernández, Mariana, Muñoz-Santos, Diego, Lamers, Mart M, van Haperen, Rien, Li, Wentao, Drulyte, Ieva, Wang, Chunyan, Sola, Isabel, Armando, Federico, Beythien, Georg, Ciurkiewicz, Malgorzata, Baumgärtner, Wolfgang, Guilfoyle, Kate, Smits, Tony, van der Lee, Joline, van Kuppeveld, Frank J M, van Amerongen, Geert, Haagmans, Bart L, Enjuanes, Luis, Osterhaus, Albert D M E, Grosveld, Frank, Bosch, Berend-Jan, Virologie, dI&I I&I-1, Bedrijfsvoering

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Science immunology, 7(73), 1. American Association for the Advancement of Science
Science immunology, 7(73):eabp9312. American Association for the Advancement of Science
Sci Immunol.

The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which displays striking immune escape potential through mutations at key antigenic sites on the spike protein. Many of these mutations localize to the spike protein ACE2 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbd3210dd42023f49fb595389bc79fd
https://doi.org/10.1126/sciimmunol.abp9312