Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Drugs screening"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionPancreatic ductal adenocarcinoma (PDAC) has the highest mortality rate among all solid tumors. Tumorigenesis is promoted by the oncogene KRAS, and KRAS mutations are prevalent in patients with PDAC. Therefore, a comprehensive understandin
Externí odkaz:
https://doaj.org/article/5475e92c088d4a838e63acf1ef2dfb2d
Autor:
Nesreen F. Alkhofash, Bassam R. Ali
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 764 (2024)
ACE2, part of the angiotensin-converting enzyme family and the renin–angiotensin–aldosterone system (RAAS), plays vital roles in cardiovascular and renal functions. It is also the primary receptor for SARS-CoV-2, enabling its entry into cells. Th
Externí odkaz:
https://doaj.org/article/29d4a18d48d8433bbf148dae4ff79bb9
Autor:
Miguel F. S. de Abreu, Camila A. Wegermann, Millena S. Ceroullo, Isabella G. M. Sant’Anna, Renato C. S. Lessa
Publikováno v:
Organics, Vol 3, Iss 4, Pp 380-414 (2022)
Xanthine oxidase (XO) is an enzyme involved in the oxidative process of hypoxanthine and xanthine to uric acid (UA). This process also produces reactive oxygen species (ROS) as byproducts. Both UA and ROS are dangerous for human health, and some heal
Externí odkaz:
https://doaj.org/article/feb1c22dc921497c9ae8e2235b75aa87
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15395- (2023)
Antibiotic residues in food of animal origin is a great concern for public health worldwide in terms of antibiotic resistance development, potential allergic reactions and disruption of intestinal flora equilibrium. In this study the presence of anti
Externí odkaz:
https://doaj.org/article/05ae0a7f783c4e3da256c8a3e3518693
Akademický článek
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Autor:
Xiaoyong Guan, Shigao Huang
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Traditional tumor models cannot perfectly simulate the real state of tumors in vivo, resulting in the termination of many clinical trials. 3D tumor models’ technology provides new in vitro models that bridge the gap between in vitro and in vivo fin
Externí odkaz:
https://doaj.org/article/740f3a4b7cc44c40b4d0ec296ac9bb2e
Autor:
Xiao Wang, Mingyue Xu, Huanhuan Ke, Longda Ma, Liushuai Li, Jiang Li, Fei Deng, Manli Wang, Zhihong Hu, Jia Liu
Publikováno v:
Viruses, Vol 15, Iss 5, p 1147 (2023)
Severe fever with thrombocytopenia syndrome (SFTS) caused by a novel bunyavirus (SFTSV) is an emerging infectious disease with up to 30% case fatality. Currently, there are no specific antiviral drugs or vaccines for SFTS. Here, we constructed a repo
Externí odkaz:
https://doaj.org/article/811f5124a83a48c9b5f1252cbcf5f689
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-9 (2020)
Abstract With CA16, enterovirus-71 is the causative agent of hand foot and mouth disease (HFMD) which occurs mostly in children under 5 years-old and responsible of several outbreaks since a decade. Most of the time, HFMD is a mild disease but can pr
Externí odkaz:
https://doaj.org/article/8ce7df1954fb43b295e57f372cc81bbf
Autor:
Xiaoning Wang, Chuanxi Yang, Yangyang Sun, Xin Sui, Tong Zhu, Qian Wang, Shuai Wang, Jun Yang, Weijie Yang, Fengying Liu, Minmin Zhang, Yongan Wang, Yuan Luo
Publikováno v:
Environment International, Vol 147, Iss , Pp 106361- (2021)
Corona virus disease 2019 has spread worldwide, and appropriate drug design and screening activities are required to overcome the associated pandemic. Using computational simulation, blockade mechanism of SARS-CoV-2 spike receptor binding domain (S R
Externí odkaz:
https://doaj.org/article/d52ef302181146ffbefec99a9111a2ad
Autor:
Pedro S. Sampaio, Cecília R. C. Calado
Publikováno v:
Antibiotics, Vol 9, Iss 12, p 897 (2020)
Helicobacter pylori colonizes the human stomach of half of the world’s population. The infection if not treated, persists through life, leading to chronic gastric inflammation, that may progress to severe diseases as peptic ulcer, gastric adenocarc
Externí odkaz:
https://doaj.org/article/767873ed825748fe968d8c9103f0178c