Zobrazeno 1 - 10
of 857
pro vyhledávání: '"Drug-induced hepatotoxicity"'
Autor:
Frederick Nchang Cho, Eric A. Achidi, Jude Eteneneng Enoh, Srinivas Reddy Pallerla, Le Thi Kieu Linh, Hoang Van Tong, Joseph Kamgno, Véronique Beng Penlap, Ayola Akim Adegnika, Jean-Bernard Lekana-Douki, Marielle Karine Bouyou-Akotet, Gauthier Mesia Kahunu, Gaston Tona Lutete, Mathew Bates, John Tembo, Linzy Elton, Timothy D McHugh, Martin P Grobusch, Alimuddin Zumla, Francine Ntoumi, Thirumalaisamy P. Velavan
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Human immunodeficiency virus (HIV) and tuberculosis (TB) are major contributors to morbidity and mortality in sub-Saharan Africa including Cameroon. Pharmacogenetic variants could serve as predictors of drug-induced hepatotoxicity
Externí odkaz:
https://doaj.org/article/45dbcd854c574d1a83341fa60c612ae4
Publikováno v:
Monaldi Archives for Chest Disease (2024)
The N-acetyltransferase 2 (NAT2) gene exhibits substantial genetic diversity, leading to distinct acetylator phenotypes among individuals. In this study, we determine NAT2 gene polymorphisms in tuberculosis (TB) patients and analyze serum isoniazid (
Externí odkaz:
https://doaj.org/article/5add9f8a1d28433b8037d73e4bb30601
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 923-933 (2024)
Due to its rising global prevalence, liver failure treatments are urgently needed. Sinomenine (SIN), an alkaloid from sinomenium acutum, is being studied for its liver-repair properties due to Acetaminophen (APAP) overdose. SIN’s effect on APAP-ind
Externí odkaz:
https://doaj.org/article/6752f1efca9a44418aad479a0ef9fa46
Autor:
I. A. Mazerkina
Publikováno v:
Безопасность и риск фармакотерапии, Vol 11, Iss 2, Pp 204-214 (2023)
Idiosyncratic drug-induced liver injury (iDILI) is a rare and poorly predictable adverse drug reaction that may lead to death or liver transplantation in severe cases.The aim of the study was to review contemporary concepts of the immune-mediated pat
Externí odkaz:
https://doaj.org/article/023f61028a714e128db17bba6a2c5489
Autor:
Tomohiro Shintani, Chiharu Imamura, Yukiko Ueyama-Toba, Jumpei Inui, Akira Watanabe, Hiroyuki Mizuguchi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 429-442 (2023)
Uridine diphosphate glucuronosyltransferases (UGTs) are highly expressed in the liver and are involved in the metabolism of many drugs. In particular, UGT1A1 has a genetic polymorphism that causes decreased activity, leading to drug-induced hepatotox
Externí odkaz:
https://doaj.org/article/0da7f363b32e471eaecb3637f51d4d21
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Akademický článek
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Publikováno v:
Clinical Phytoscience, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Background Drug-induced hepatotoxicity is one of the most important causes of liver dysfunction. Acetaminophen (paracetamol) an analgesic-antipyretic drug is generally considered safe but its overdose may cause liver toxicity. Marine macro-a
Externí odkaz:
https://doaj.org/article/fe78578622a6403fb92d7ad626c106a8
Publikováno v:
Life, Vol 13, Iss 5, p 1173 (2023)
Andrographis paniculata is a herbal plant used in traditional medicinal approaches to treat various ailments and diseases. Methotrexate (MTX) is a clinically used immunosuppressant and anticancer drug. One of the increasing concerns with MTX use is l
Externí odkaz:
https://doaj.org/article/57fc617aa76e4bbabb124948fb6dd9de