Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Drug-Target Mendelian Randomization"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Autophagy is a crucial mechanism for maintaining cellular homeostasis and responding to environmental stress, and it is closely linked to tumor drug resistance. Through multi-omics analysis, this study explores the expression patt
Externí odkaz:
https://doaj.org/article/9cd76a4110664d2daf6bf8b98a58e524
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a respiratory disorder of obscure etiology and limited treatment options, possibly linked to dysregulation in lipid metabolism. While several observational studies suggest that lipid-lowering
Externí odkaz:
https://doaj.org/article/c43af1f9153c4d3c9e3a77fabb06097f
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Purpose The potential efficacy of metformin in breast cancer (BC) has been hotly discussed but never conclusive. This genetics-based study aimed to evaluate the relationships between metformin targets and BC risk. Methods Metformin targets f
Externí odkaz:
https://doaj.org/article/1829aa2b3194493fa655392f3555b914
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundPolycystic ovary syndrome (PCOS), a prevalent endocrine disorder in women of reproductive age, is mainly ameliorated through drugs or lifestyle changes, with limited treatment options. To date, numerous researchers have found that fertility
Externí odkaz:
https://doaj.org/article/40c3e926ed974e0796f70368a9da10f6
Autor:
Gailing Liu
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
AimSodium-glucose cotransporter protein 2 (SGLT2) inhibitors have been shown to have renoprotective effects in clinical studies. For further validation in terms of genetic variation, drug-targeted Mendelian randomization (MR) was used to investigate
Externí odkaz:
https://doaj.org/article/1735342131fe4c2a9c60a13e173b8b7c
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveAddressing the rising prevalence of pain disorders and limitations of current analgesics, our study explores repurposing antihypertensive drugs for pain management, inspired by the link between hypertension and pain. We leverage a drug-targe
Externí odkaz:
https://doaj.org/article/e0099fd19cf74b679db5c9011d14bb63
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundPrevious observational studies have reported a possible association between circulating lipids and lipid-lowering drugs and male infertility (MIF), as well as the mediating role of circulating vitamin D. Then, due to issues such as bias, re
Externí odkaz:
https://doaj.org/article/ace072ab7d914693a647fd15686136df
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundColorectal cancer is influenced by several factors such as unhealthy habits and genetic factors. C1QB has been linked to a number of malignancies. However, uncertainty surrounds the connection between C1QB and CRC. Therefore, this study aim
Externí odkaz:
https://doaj.org/article/03e6e3c1e94f4bcc8945533e31cf1673
Publikováno v:
Brain and Behavior, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background In addition to lowering cholesterol levels, the proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has a variety of effects, including anti‐neuroapoptosis. However, the effects of PCSK9 inhibitors on neurodegenerative dise
Externí odkaz:
https://doaj.org/article/77620701ee6d4058a0a9f70a91c6c0c6
Autor:
Daniel B. Rosoff, Andrew S. Bell, Josephin Wagner, Lucas A. Mavromatis, Ali Hamandi, Lauren Park, Jeesun Jung, Falk W. Lohoff
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 29-40 (2024)
Background & Aims: Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse liver outcomes; however, liver disease incidence varies across diverse popul
Externí odkaz:
https://doaj.org/article/0796deca2c944246820bcca9f91393cf