Zobrazeno 1 - 10
of 4 620
pro vyhledávání: '"Drug transport"'
Publikováno v:
Alexandria Engineering Journal, Vol 107, Iss , Pp 184-197 (2024)
Topical medications are common initial treatments for Descemet’s membrane detachment (DMD). It is crucial to understand the aqueous humour (AH) flow and drug transport to facilitate the DMD treatment. This paper presents a mathematical model to ana
Externí odkaz:
https://doaj.org/article/15bd67f76ff64b1a87fdca226bc50617
Autor:
Evgeniya Mickols, Alina Meyer, Niklas Handin, Malin Stüwe, Jens Eriksson, Jakob Rudfeldt, Kristin Blom, Mårten Fryknäs, Mikael E. Sellin, Volker M. Lauschke, Maria Karlgren, Per Artursson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract 3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated phenotype with largely conserved metabolic function and proteomic fingerprint over weeks in culture. As a result, 3D PHH are gaining importance as a model for mechani
Externí odkaz:
https://doaj.org/article/14b6909630ac42c4af6b2cef75b8a422
Autor:
Yuanjin Zhang, Junze Huang, Shengbo Huang, Jie Liu, Luyao Deng, Chenmeizi Liang, Yuanqing Guo, Bingyi Yao, Xin Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1592-1604 (2024)
Organic anion-transporting polypeptides 1B1 (OATP1B1) plays a crucial role in the transport of statins. However, there are too few animal models related to OATP1B1, especially humanized animal models. In this study, the human SLCO1B1 cDNA was inserte
Externí odkaz:
https://doaj.org/article/e5278a73392e48af84ff4437c01b56b1
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/a07e9559db6a4bb691f769175ea70302
Autor:
Rodnie Colón Ortiz, Stephen Knerler, Lisa B. Fridman, Alicia Mercado, Amira-Storm Price, Jose J. Rosado-Franco, Hannah Wilkins, Bianca R. Flores, Benjamin C. Orsburn, Dionna W. Williams
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-27 (2024)
Abstract Background Appropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of the brain to achieve HIV suppression. These
Externí odkaz:
https://doaj.org/article/e4b502e6cecf445b9bae2fbc5aac1494
Autor:
Anna Bogdanova, Lars Kaestner
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/9da395d1f4f4427a82d83fe254a2e538
Autor:
Aaron O. Buaben, Ryan M. Pelis
Publikováno v:
Journal of Xenobiotics, Vol 13, Iss 2, Pp 205-217 (2023)
Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing
Externí odkaz:
https://doaj.org/article/1c4dd1fcaec047bb8652360939252eeb
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 592 (2024)
The movement of organic anionic drugs across cell membranes is partly governed by interactions with SLC and ABC transporters in the intestine, liver, kidney, blood–brain barrier, placenta, breast, and other tissues. Major transporters involved incl
Externí odkaz:
https://doaj.org/article/22cfc76d521c43cf8c27e293b99e5443
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
This review focuses on the role of human red blood cells (RBCs) as drug carriers. First, a general introduction about RBC physiology is provided, followed by the presentation of several cases in which RBCs act as natural carriers of drugs. This is du
Externí odkaz:
https://doaj.org/article/50b1217d45ab446a9d7691927f0fc81e
Autor:
Anne T. Nies, Jörg König, Patrick Leuthold, Katja Damme, Stefan Winter, Mathias Haag, Satohiro Masuda, Stephan Kruck, Hannelore Daniel, Britta Spanier, Martin F. Fromm, Jens Bedke, Ken-ichi Inui, Matthias Schwab, Elke Schaeffeler
Publikováno v:
Pharmacological Research, Vol 196, Iss , Pp 106941- (2023)
Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous compounds and drugs across membranes, thus playing a critical role in disease susceptibility and drug response. Because only a limited number of transporter s
Externí odkaz:
https://doaj.org/article/a586ce376abb4a7f9f1e1058fa095696