Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Drug target identification"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1755-1772 (2024)
Building data-driven models is an effective strategy for information extraction from empirical data. Adapting model parameters specifically to data with a best fitting approach encodes the relevant information into a mathematical model. Subsequently,
Externí odkaz:
https://doaj.org/article/d3a52f8dfa6047e2b8a697f109ed8816
Autor:
Alqurashi Abdulmajeed, Ahmad Waqar, Rahman Ziaur, Nawab Javed, Siddiqui Muhammad Faisal, Akbar Ali, Alkraiem Ayman Ahmad, Latif Muhammad
Publikováno v:
Open Chemistry, Vol 22, Iss 1, Pp 521-30 (2024)
This study applied a subtractive genomics approach to identify a potential drug target in the Porphyromonas gingivalis strain (ATCC BAA-308/W83). The aim was to characterize the whole proteome and hypothetical proteins (HPs) through structural, funct
Externí odkaz:
https://doaj.org/article/499cc69cfdac4a31af3d13394d5473bd
Autor:
Muhammad Fayaz Khan, Amjad Ali, Hafiz Muzzammel Rehman, Sadiq Noor Khan, Hafiz Muhammad Hammad, Maaz Waseem, Yurong Wu, Taane G. Clark, Abdul Jabbar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-24 (2024)
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis, ranks among the top causes of global human mortality, as reported by the World Health Organization’s 2022 TB report. The prevalence of M. tuberculosis strains that are multiple and e
Externí odkaz:
https://doaj.org/article/40ba6f88b61a421d95e5f190f15addae
Autor:
Kajal Gupta
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-8 (2023)
Abstract Background Monkeypox virus is a small, double-stranded DNA virus that causes a zoonotic disease called Monkeypox. The disease has spread from Central and West Africa to Europe and North America and created havoc in some countries all around
Externí odkaz:
https://doaj.org/article/ca9bbaba34cf4c9ebcbb3bdea58590e0
Autor:
Aziz Belkadi, Gaurav Thareja, Fatemeh Abbaszadeh, Ramin Badii, Eric Fauman, Omar M.E. Albagha, Karsten Suhre
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100218- (2023)
Summary: Natural human knockouts of genes associated with desirable outcomes, such as PCSK9 with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found i
Externí odkaz:
https://doaj.org/article/e1770f153d584d008d88b05b5bb7250b
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
The concept of the druggable genome has been with us for 20 years. During this time, researchers have developed several methods and resources to help assess a target’s druggability. In parallel, evidence for target-disease associations has been col
Externí odkaz:
https://doaj.org/article/d95b91af827e40beba23f2ba7203ac19
Akademický článek
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Autor:
Ophélie Lo-Thong-Viramoutou, Philippe Charton, Xavier F. Cadet, Brigitte Grondin-Perez, Emma Saavedra, Cédric Damour, Frédéric Cadet
Publikováno v:
Frontiers in Artificial Intelligence, Vol 5 (2022)
The use of machine learning (ML) in life sciences has gained wide interest over the past years, as it speeds up the development of high performing models. Important modeling tools in biology have proven their worth for pathway design, such as mechani
Externí odkaz:
https://doaj.org/article/5e2368f34bbc4da9a09e2e2edb1c0a96