Zobrazeno 1 - 10
of 4 813
pro vyhledávání: '"Drug response"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug response
Externí odkaz:
https://doaj.org/article/f1c9552d84e14eafa67c1b5380b0805d
Autor:
Yen Thi My Nguyen, Bao-Quoc Vu, Duy-Khai Nguyen, Ngoc-Vinh Quach, Liem Thanh Bui, Jeonghan Hong, Chi-Bao Bui
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Neonatal intensive care unit (NICU), particularly in treating developmental and epileptic encephalopathy (DEE) and metabolic epilepsy (ME), requires a deep understanding of their complex etiologies and treatment responses. After excluding tr
Externí odkaz:
https://doaj.org/article/82f123a85d2440b7ba55d63af1b5887e
Autor:
Stefan Schmidt, Alexander Geisel, Thomas Enzlein, Björn C. Fröhlich, Louise Pritchett, Melanie Verneret, Christian Graf, Carsten Hopf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Potency assessment of monoclonal antibodies or corresponding biosimilars in cell-based assays is an essential prerequisite in biopharmaceutical research and development. However, cellular bioassays are still subject to limitations in sample
Externí odkaz:
https://doaj.org/article/4e15564bbbfa4cfeaf410123fd917c83
Autor:
Stearns, Stephen C., author, Medzhitov, Ruslan, author
Publikováno v:
Evolutionary Medicine, 2024, ill.
Externí odkaz:
https://doi.org/10.1093/oso/9780192871978.003.0005
Publikováno v:
JAAD Case Reports, Vol 51, Iss , Pp 97-99 (2024)
Externí odkaz:
https://doaj.org/article/5d18446bdc204cd4a71c27fab40edbeb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Acute myeloid leukemia (AML) exhibits pronounced heterogeneity and chemotherapy resistance. Aberrant programmed cell death (PCD) implicated in AML pathogenesis suggests PCD-related signatures could serve as biomarkers to predict clinical out
Externí odkaz:
https://doaj.org/article/e79c72f0ad79490f88b5fa41f300991a
Publikováno v:
Onco, Vol 4, Iss 3, Pp 143-162 (2024)
As precision medicine such as targeted therapy and immunotherapy often have limited accessibility, low response rate, and evolved resistance, it is urgent to develop simple, low-cost, and quick-turnaround personalized diagnostic technologies for drug
Externí odkaz:
https://doaj.org/article/2de7fac8377548099f7b8e31f963a18b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Considering the key role of myeloid cell differentiation—related genes in the tumor microenvironment (TME), we aimed to build a prognostic risk model using these genes for Lung adenocarcinoma (LUAD). The mRNA gene expression profiles of LU
Externí odkaz:
https://doaj.org/article/430fa27589c14aeba0b57e9feafd9d9f
Autor:
Denys Oliinyk, Andreas Will, Felix R Schneidmadel, Maximilian Böhme, Jenny Rinke, Andreas Hochhaus, Thomas Ernst, Nina Hahn, Christian Geis, Markus Lubeck, Oliver Raether, Sean J Humphrey, Florian Meier
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 972-995 (2024)
Abstract Mass spectrometry has revolutionized cell signaling research by vastly simplifying the analysis of many thousands of phosphorylation sites in the human proteome. Defining the cellular response to perturbations is crucial for further illumina
Externí odkaz:
https://doaj.org/article/6e562a7488544cb3987d5a02f54ee0a2
Publikováno v:
JEADV Clinical Practice, Vol 3, Iss 2, Pp 664-667 (2024)
Abstract We report a 4‐year‐old girl developing therapy refractory paronychia induced by selumetinib, an oral selective inhibitor of mitogen‐activated protein kinase 1/2 prescribed for a large submandibular plexiform neurofibroma. Although this
Externí odkaz:
https://doaj.org/article/747a71434a35474884a9290009496a32