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pro vyhledávání: '"Drug resistant mutants"'
Akademický článek
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Akademický článek
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Publikováno v:
Methods in Molecular Biology ISBN: 9781071617786
Generation and characterization of drug resistant mutants is a powerful tool in antimicrobial drug discovery for identification of the molecular target of an investigational drug candidate. The method is relatively simple to be conducted in a classic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::880205e65fdc63b18124ef055523cadb
https://doi.org/10.1007/978-1-0716-1779-3_20
https://doi.org/10.1007/978-1-0716-1779-3_20
Autor:
Waqas Nawaz, Huanru Wang, Ye Liu, Enhui Yang, Bingxin Liu, Fang Zhang, Qiao You, Deyan Chen, Shijie Xu, Zhiwei Wu
Publikováno v:
Biologicalpharmaceutical bulletin. 44(9)
Herpes simplex virus-1 (HSV-1) infection of the eyes leads to herpes simplex virus keratitis (HSK), the main cause of infectious blindness in the world. As the current therapeutics for HSV-1 infection are rather limited and prolonged use of acyclovir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc879f58dd1d69d6f08d8ff09f4c534c
https://pubmed.ncbi.nlm.nih.gov/34162786
https://pubmed.ncbi.nlm.nih.gov/34162786
Autor:
Sebastian H. Grimm, Eelke B. Lenselink, Adriaan W. Tuin, Constant A. A. van Boeckel, Adrianus M. C. H. van den Nieuwendijk, Ruud H. Wijdeven, Jordi F. Keijzer, Mario van der Stelt, Herman S. Overkleeft, Jacques Neefjes, Nora Liu, Gerard J. P. van Westen, Berend Gagestein
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 27(5), 692-699
Bioorganic and Medicinal Chemistry, 27(5), 692-699
Acute myeloid leukemia (AML) is characterized by fast progression and low survival rates, in which Fms-like tyrosine kinase 3 (FLT3) receptor mutations have been identified as a driver mutation in cancer progression in a subgroup of AML patients. Cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8645479c35cd969df474b85b828fdea0
https://doi.org/10.1016/j.bmc.2019.01.006
https://doi.org/10.1016/j.bmc.2019.01.006
Autor:
Woo Jin Shin, Baik Lin Seong
Publikováno v:
Expert Opinion on Drug Discovery. 14:153-168
INTRODUCTION The emergence of drug-resistant influenza virus strains highlights the need for new antiviral therapeutics to combat future pandemic outbreaks as well as continuing seasonal cycles of influenza. Areas covered: This review summarizes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec4a5165b78f5ec9536c75831ac7aba
https://doi.org/10.1080/17460441.2019.1560261
https://doi.org/10.1080/17460441.2019.1560261
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1980 Apr 01. 77(4), 2270-2273.
Externí odkaz:
https://www.jstor.org/stable/8643
Autor:
Carver, J. H.
Publikováno v:
In Vitro, 1983 Sep 01. 19(9), 699-706.
Externí odkaz:
https://www.jstor.org/stable/4292729
Autor:
Dominik Wodarz
Publikováno v:
Cancer Res
Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240d123f6dc145422fe0377dba7b718c
https://pubmed.ncbi.nlm.nih.gov/33172930
https://pubmed.ncbi.nlm.nih.gov/33172930