Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Drug protein interactions"'
Publikováno v:
In Journal of Chromatography B 15 October 2024 1247
Autor:
Selvaraj Jayaraman, Sathan Raj Natarajan, Bhuvaneswari Ponnusamy, Vishnu Priya Veeraraghavan, Sharmila Jasmine
Publikováno v:
Saudi Dental Journal, Vol 35, Iss 8, Pp 1007-1013 (2023)
The global increase in the prevalence of oral neoplasms and related deaths can be attributed to social development and lifestyle factors, leading to poor prognosis and a lack of early clinical detection. Oral cancer ranks ranked sixth mostly diagnose
Externí odkaz:
https://doaj.org/article/05e10cffff06429f9abc48d4ac77aec0
Autor:
Luthary Segura, Natalia Santos, Rafael Flores, Donald Sikazwe, Miles McGibbon, Vincent Blay, Kwan H. Cheng
Publikováno v:
Molecules, Vol 29, Iss 12, p 2818 (2024)
Intracellular tau fibrils are sources of neurotoxicity and oxidative stress in Alzheimer’s. Current drug discovery efforts have focused on molecules with tau fibril disaggregation and antioxidation functions. However, recent studies suggest that me
Externí odkaz:
https://doaj.org/article/240ab94f2ab64bc6b0ba6644c8acdd24
Autor:
Zhong-Hao Ren, Zhu-Hong You, Quan Zou, Chang-Qing Yu, Yan-Fang Ma, Yong-Jian Guan, Hai-Ru You, Xin-Fei Wang, Jie Pan
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Drug-target interaction (DTI) prediction has become a crucial prerequisite in drug design and drug discovery. However, the traditional biological experiment is time-consuming and expensive, as there are abundant complex interactio
Externí odkaz:
https://doaj.org/article/1406626ae0cc4a6a920398d0c7e50d7e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
The salt bridge is the strongest non-covalent interaction in nature and is known to participate in protein folding, protein-protein interactions, and molecular recognition. However, the role of salt bridges in the context of drug design has remained
Externí odkaz:
https://doaj.org/article/72c0137f46e14ba48980298e0ed7c38b
Publikováno v:
Biophysica, Vol 1, Iss 3, Pp 344-358 (2021)
A dataset containing the experimental values of the equilibrium binding constants of clinical drugs, and some other organic ligands with human and mammalian (predominantly bovine) serum albumins, is assembled. The affinity of drugs to albumin governs
Externí odkaz:
https://doaj.org/article/db431c9b339841f2a0ff84662e5cfbb5
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
During the process of drug discovery, exploring drug-protein interactions (DPIs) is a key step. With the rapid development of biological data, computer-aided methods are much faster than biological experiments. Deep learning methods have become popul
Externí odkaz:
https://doaj.org/article/3de2e3116d264911bf99628f8e83762f
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Polypharmacy is a type of treatment that involves the concurrent use of multiple medications. Drugs may interact when they are used simultaneously. So, understanding and mitigating polypharmacy side effects are critical for patien
Externí odkaz:
https://doaj.org/article/53a170df920a4b33b329748272390dad
Autor:
Wanying Wu, Tianqing Jiang, Haihui Lin, Chao Chen, Lingling Wang, Jikai Wen, Jun Wu, Yiqun Deng
Publikováno v:
Metabolites, Vol 13, Iss 5, p 601 (2023)
Human AKR 7A2 broadly participates in the metabolism of a number of exogenous and endogenous compounds. Azoles are a class of clinically widely used antifungal drugs, which are usually metabolized by CYP 3A4, CYP2C19, and CYP1A1, etc. in vivo. The az
Externí odkaz:
https://doaj.org/article/ac5ed696ac4c4f5a8498c01243ca7e2e
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