Zobrazeno 1 - 10
of 581
pro vyhledávání: '"Drug induced liver injury (DILI)"'
Publikováno v:
COVID, Vol 4, Iss 7, Pp 910-920 (2024)
NSAIDs and paracetamol are commonly used as antipyretic treatments, which may impair renal and hepatic function, respectively. Both organ systems are also negatively affected by COVID-19. In two retrospective case–control studies, we investigated w
Externí odkaz:
https://doaj.org/article/4a222b59ae4e44c4bc40e95338eaf742
Autor:
Xiaomeng Zhang, Zhiwen Cao, Li Li, Peipei Lu, Qi Geng, Lan Yan, Bin Liu, Lin Lin, Lulu Zhang, Changqi Shi, Yong Tan, Xiaojuan He, Ning Zhao, Cheng Lu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117481- (2024)
Triptolide (TP), a diterpene from Tripterygium wilfordii, exhibits potent anti-inflammatory, immunomodulatory, and antitumor properties but is limited by severe hepatotoxicity. This study investigates sex differences in TP-induced liver injury and th
Externí odkaz:
https://doaj.org/article/74de01d4d23e43529eaca5814112ce01
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 3022-3038 (2024)
A hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive
Externí odkaz:
https://doaj.org/article/7509311fa3dc4a079d6b3fd790c1447b
Autor:
Lubova Renemane, Elmars Rancans
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
This case report describes a patient with major depressive disorder (MDD) who developed acute hepatocellular liver injury after being treated with sertraline, a selective serotonin reuptake inhibitor (SSRI). The diagnosis of MDD was made two years pr
Externí odkaz:
https://doaj.org/article/c814d7e5df654ecdbcdf9885a1530dd1
Autor:
J.A. Velarde-Ruiz Velasco, D.K. Tapia Calderón, S. Cerpa-Cruz, J.A. Velarde-Chávez, J.F. Uribe Martínez, E.S. García Jiménez, J.M. Aldana Ledesma, Á. Díaz-González, J. Crespo
Publikováno v:
Revista de Gastroenterología de México, Vol 89, Iss 1, Pp 106-120 (2024)
Resumen: La inmunoterapia con inhibidores de puntos de control inmunitario (ICP) ha revolucionado el manejo del cáncer avanzado, sin embargo, el uso generalizado de estos medicamentos ha llevado al aumento en la incidencia de eventos adversos inmuno
Externí odkaz:
https://doaj.org/article/bf56585ac1da46ea8f42fb6c9ebdebb0
Autor:
Lusine Tonoyan, Arno G. Siraki
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Machine learning (ML) in toxicological sciences is growing exponentially, which presents unprecedented opportunities and brings up important considerations for using ML in this field. This review discusses supervised, unsupervised, and reinforcement
Externí odkaz:
https://doaj.org/article/d1d3749e46bb466c8c4a35fe0eb1fbe2
Autor:
Fahad Mostafa, Minjun Chen
Publikováno v:
Frontiers in Toxicology, Vol 5 (2024)
Drug-induced liver injury (DILI) is a severe adverse reaction caused by drugs and may result in acute liver failure and even death. Many efforts have centered on mitigating risks associated with potential DILI in humans. Among these, quantitative str
Externí odkaz:
https://doaj.org/article/b1333d98410d4084bf676b1dbcc397a6
Autor:
Alejandro Cueto-Sánchez, Daniel E. Di Zeo-Sánchez, Antonio Segovia-Zafra, Gonzalo Matilla-Cabello, Ana Bodoque-García, María Isabel Lucena, Marina Villanueva-Paz
Publikováno v:
Exploration of Digestive Diseases, Vol 2, Iss 2, Pp 56-76 (2023)
The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) alleles with DILI due to specific drugs support the c
Externí odkaz:
https://doaj.org/article/376a91ad0efd4cadb235fdb15eb60000
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 535 (2024)
Predicting whether a compound can cause drug-induced liver injury (DILI) is difficult due to the complexity of drug mechanism. The cysteine trapping assay is a method for detecting reactive metabolites that bind to microsomes covalently. However, it
Externí odkaz:
https://doaj.org/article/b19b5a91c9444b489ae2fb9e4b25b92a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.