Zobrazeno 1 - 10
of 2 871
pro vyhledávání: '"Drug disposition"'
Autor:
Yuanjin Zhang, Junze Huang, Shengbo Huang, Jie Liu, Luyao Deng, Chenmeizi Liang, Yuanqing Guo, Bingyi Yao, Xin Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1592-1604 (2024)
Organic anion-transporting polypeptides 1B1 (OATP1B1) plays a crucial role in the transport of statins. However, there are too few animal models related to OATP1B1, especially humanized animal models. In this study, the human SLCO1B1 cDNA was inserte
Externí odkaz:
https://doaj.org/article/e5278a73392e48af84ff4437c01b56b1
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Cholestasis, a chronic liver condition, disrupts bile acid homeostasis and complicates drug disposition, posing significant challenges in medicating cholestatic patients. Drug metabolism enzymes and transporters (DMETs) are pivotal in drug c
Externí odkaz:
https://doaj.org/article/ab016390b6ff48b995135561f3728c35
Autor:
Rajbharan Yadav, Suzanne Schubbert, Patrick G. Holder, Eugene Y. Chiang, Nargess Kiabi, Liz Bogaert, Irene Leung, Rumana Rashid, Kendra N. Avery, Christine Bonzon, John R. Desjarlais, Shomyseh Sanjabi, Amy Sharma, Michelle Lepherd, Amy Shelton, Pam Chan, Yanqiu Liu, Louis Joslyn, Iraj Hosseini, Eric G. Stefanich, Amrita V. Kamath, Matthew J. Bernett, Vittal Shivva
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionInterleukin 15 (IL-15) is a potential anticancer agent and numerous engineered IL-15 agonists are currently under clinical investigation. Selective targeting of IL-15 to specific lymphocytes may enhance therapeutic effects while helping t
Externí odkaz:
https://doaj.org/article/31030b79b4034614806d2f9e04a075ba
Autor:
Hao Liang, Zhenling Deng, Shu Niu, Weijie Kong, Yang Liu, Song Wang, Haiyan Li, Yue Wang, Danxia Zheng, Dongyang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Primary membranous nephropathy (PMN) is the most common cause for adult nephrotic syndrome. Rituximab has demonstrated promising clinical efficacy by random controlled trials and the off-label use is widely adopted in PMN. However, the standard dosag
Externí odkaz:
https://doaj.org/article/fa3fc666840040b79fe313ea6851bd16
Publikováno v:
Current Research in Toxicology, Vol 6, Iss , Pp 100149- (2024)
Tofacitinib is a small molecule Janus kinase (JAK) inhibitor, introduced to the European market in 2017, for the treatment of rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. In the treatment of women with autoimmune diseases, pregna
Externí odkaz:
https://doaj.org/article/0dd656059de5435ba0d70e631e0990d4
Akademický článek
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Autor:
Iraj Hosseini, Brett Fleisher, Jennifer Getz, Jérémie Decalf, Mandy Kwong, Meric Ovacik, Travis W. Bainbridge, Christine Moussion, Gautham K. Rao, Kapil Gadkar, Amrita V. Kamath, Saroja Ramanujan
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 660 (2024)
FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic/pharmacodynamic (PK/PD) relationship, with observed nonlinear PK and expansion
Externí odkaz:
https://doaj.org/article/2aeee9c733c94287888bd277150996d7
Akademický článek
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Autor:
Wenlong Li, Dilek Iusuf, Rolf W. Sparidans, Els Wagenaar, Yaogeng Wang, Dirk R. de Waart, Margarida L.F. Martins, Stéphanie van Hoppe, Maria C. Lebre, Olaf van Tellingen, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106724- (2023)
Organic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake transport of structurally diverse endogenous and exogenous compounds. To investigate the roles of OATP2B1 in physiology and pharmacology, we established and characterized
Externí odkaz:
https://doaj.org/article/f8d2c24093e5489fb6812b02a2a65cfa
Akademický článek
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