Flubendazole carbonyl reduction in drug-susceptible and drug-resistant strains of the parasitic nematode Haemonchus contortus: changes during the life cycle and possible inhibition

Autor: Nikola Rychlá, Martina Navrátilová, Eliška Kohoutová, Lucie Raisová Stuchlíková, Karolína Štěrbová, Josef Krátký, Petra Matoušková, Barbora Szotáková, Lenka Skálová

Publikováno v: Veterinary Research, Vol 55, Iss 1, Pp 1-11 (2024)

Abstract Carbonyl-reducing enzymes (CREs) catalyse the reduction of carbonyl groups in many eobiotic and xenobiotic compounds in all organisms, including helminths. Previous studies have shown the important roles of CREs in the deactivation of severa

Externí odkaz: https://doaj.org/article/5757a5985b1d4931a16eb602e217b7e7

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Recent advances in the ontogeny of drug disposition

Autor: Brian D. Chapron, Alenka Chapron, J. Steven Leeder

Publikováno v: Br J Clin Pharmacol

Developmental changes that occur throughout childhood have long been known to impact drug disposition. However, pharmacokinetic studies in the paediatric population have historically been limited due to ethical concerns arising from incorporating chi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22e905df409a9f066110f306f4c3f82
https://doi.org/10.1111/bcp.14821

Preparation of Frozen Sections of Multicellular Tumor Spheroids Coated with Ice for Mass Spectrometry Imaging

Autor: Peisi Xie, Wei Huang, Chao Zhao, Zongwei Cai, Yanyan Chen, Xiaoping Liang

Publikováno v: Analytical Chemistry. 92:7413-7418

Increasing studies have utilized mass spectrometry imaging (MSI) that is a label-free tool to investigate drug penetration and drug biotransformation in multicellular tumor spheroids (MCTS). Currently, the gelatin-assisted sectioning method is widely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae9367631cac81229a5c0c3678ad40b
https://doi.org/10.1021/acs.analchem.9b05812

Espectrometria de massas avançada em estudos estruturais de metabólitos de fármacos e proteínas

Autor: Gomes, Alexandre Ferreira, 1984

Publikováno v: Biblioteca Digital de Teses e Dissertações da Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP

Orientador: Fábio Cesar Gozzo Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química Resumo: Este trabalho foi dividido em dois capítulos, tendo como temática geral a aplicação de técnicas modernas baseadas em espectrometri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4634d539b0139e11584564f50650f66c
https://doi.org/10.47749/t/unicamp.2014.937745