Výsledky vyhledávání - "Drug binding site"

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Akademický článek

Lysine 268 adjacent to transmembrane helix 5 of hamster P‐glycoprotein is the major photobinding site of iodomycin in CHO B30 cells

Autor: Annette Demmer, Hubert Thole, Manfred Raida, Burkhard Tümmler

Publikováno v: FEBS Open Bio, Vol 11, Iss 4, Pp 1084-1092 (2021)

P‐glycoprotein (Pgp) detoxifies cells by exporting hundreds of chemically dissimilar hydrophobic and amphipathic compounds and is implicated in multidrug resistance (MDR) in the treatment of cancers. Photoaffinity labeling of plasma membrane vesicl

Externí odkaz: https://doaj.org/article/c2b81dd83c9042d1b7692f7ae5d4f30b

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Effects of long- and medium-chain fatty acids on disopyramide and lidocaine that bind to the drug site of human α₁ -acid glycoprotein

Publikováno v: 九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare. 24:31-35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::a5dcc5ca4391a2fe7ca43173b3d063d4
http://id.nii.ac.jp/1147/00001493/

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Akademický článek

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Akademický článek

All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site

Autor: Wu Xu, Xiao-Jun Xie, Ali K. Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A. Naquin, Avery C. Walton, Peter W. Kishbaugh, Jun-Yuan Ji

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 20, p 7511 (2020)

Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved roles in modulating RNA polymerase II (Pol II)-dependent gene expression. To understand the structure and function relations of CDK8, we analyzed the structure

Externí odkaz: https://doaj.org/article/80c69c08698449078c35cee84523329a

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Structure-based identification of galectin-1 selective modulators in dietary food polyphenols: a pharmacoinformatics approach

Autor: Zeid A. ALOthman, Tahany Saleh Aldayel, Saikh Mohammad Wabaidur, Nora Abdullah AlFaris, Jozaa Zaidan ALTamimi, Shovonlal Bhowmick, Ataul Islam, Achintya Saha

Publikováno v: Molecular Diversity. 26:1697-1714

Abstract In this study, a set of dietary polyphenols was comprehensively studied for the selective identification of the potential inhibitors/modulators for galectin-1. Galectin-1 is a potent prognostic indicator of tumor progression and a highly reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca190653cb939484d47a8bf994b1fcc
https://doi.org/10.1007/s11030-021-10297-1

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Identification of a critical binding site for local anaesthetics in the side pockets of K v 1 channels

Autor: Carmen Valenzuela, Aytug K. Kiper, Alicia de la Cruz, Wendy González, Susanne Rinné, Mauricio Bedoya, David Ramírez, Teresa González, Stefanie Marzian, Niels Decher, Bárbara A Arévalo Ramos, Sarah Stalke, Alba Vera-Zambrano, José C E Márquez Montesinos, Diego A. Peraza

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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© 2021 The Authors.
[Background and Purpose]: Local anaesthetics block sodium and a variety of potassium channels. Although previous studies identified a residue in the pore signature sequence together with three residues in the S6 segment as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ae1d395f0227e4ba24d6a71b2fddc0
https://doi.org/10.1111/bph.15480

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Study on reversal of ABCB1 mediated multidrug resistance in Colon cancer by acetogenins: An in-silico approach

Autor: Subramanian Vidyalakshmi, M Jeevitha Priya, Murugesan Rajeswari

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:4273-4284

Multi-Drug Resistance (MDR) exerted by tumor cells is majorly due to the overexpression of ATP Binding cassette transporters such as ABCB1/P-glycoprotein (P-gp). Annonaceous acetogenins (AGEs) exert anticancer activity by strongly inhibiting NADH oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac32e16d4e7daf68cb640b8a218c8e12
https://doi.org/10.1080/07391102.2020.1855249

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Using a Heat Diffusion Model to Detect Potential Drug Resistance Genes of Mycobacterium tuberculosis

Autor: Hong-Yu Zhang, Qiang Zhu, Ze-Jia Cui, Weitong Zhang, Qing-Ye Zhang

Publikováno v: Protein & Peptide Letters. 27:711-717

Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the oldest known and most dangerous diseases. Although the spread of TB was controlled in the early 20th century using antibiotics and vaccines, TB has again become

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e826698c9d92e755238866d91bd0def5
https://doi.org/10.2174/0929866527666200313113157

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