Zobrazeno 1 - 10
of 6 347
pro vyhledávání: '"Drug Targets"'
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 11275-11289 (2024)
Gehua Zhu,1,* Jiaqi Li,2,* Jiamin Xu,1 Guanghua Guo,1 Feng Zhu2 1Medical Centre of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China; 2Department
Externí odkaz:
https://doaj.org/article/f69b92433c21482e982ef480a3e8ef10
Autor:
Solomon Uche Oranusi, Emmanuel Ojochegbe Mameh, Samuel Adeniyi Oyegbade, Daniel Oluwatobiloba Balogun, Victoria-Grace Onyekachi Aririguzoh
Publikováno v:
Journal of Pure and Applied Microbiology, Vol 18, Iss 4, Pp 2151-2162 (2024)
The World Health Organization documented 247 million reported malaria cases worldwide resulting in 619,000 fatalities in 2021. More than 70% of these deaths are attributed to Children under five years of age and sub-Saharan Africa is the region in wh
Externí odkaz:
https://doaj.org/article/5564bcfa20424f83a3fd0a581ad1b10b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Spinal stenosis is a commonly chronic spinal degenerative disease, which is a major cause of pain and dysfunction in the elderly. Mendelian randomization (MR) has been widely applied to repurpose licensed drugs and identify novel therapeutic
Externí odkaz:
https://doaj.org/article/aa0cd745645946de97dececa08b6a6b9
Autor:
Xin Guo, Meng-jun Tao, XinCan Ji, MengQi Han, Yue Shen, Cheng Hong, HaoYang Guo, Wei Shi, Hui Yuan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Psoriasis is a chronic inflammatory skin disorder with multiple causes, including genetic and environmental factors. Despite advances in treatment, there remains a need to identify novel therapeutic targets. A Mendelian randomization (MR) an
Externí odkaz:
https://doaj.org/article/75f8786fd6bf459cb2ac0cf1af2b1945
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Atrioventricular block (AVB) is a heterogeneous group of arrhythmias. AVB can lead to sudden arrest of the heart and subsequent syncope or sudden cardiac death. Few scholars have investigated the underlying molecular mechanisms of
Externí odkaz:
https://doaj.org/article/1300971fd455486fa5ebf74343f6cdab
Autor:
Zhonghua Xiong, Lei Zhao, Yanliang Mei, Dong Qiu, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Jin Cao, Yonggang Wang
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Migraine is a highly prevalent and complex neurovascular disease. However, the currently available therapeutic drugs often fall to adequately meet clinical needs due to limited effectiveness and numerous undesirable side effects.
Externí odkaz:
https://doaj.org/article/30cc217145b9460ea37cae279912eef8
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Background Drugs targeting disease causal genes are more likely to succeed for that disease. However, complex disease causal genes are not always clear. In contrast, Mendelian disease causal genes are well-known and druggable. Here, we seek
Externí odkaz:
https://doaj.org/article/778716eddc6d422cb7f374abc954f1e5
Autor:
Eduarda Guimarães Sousa, Andrei Giacchetto Felice, Fabiana Vieira Dominici, Arun Kumar Jaiswal, Mariana Letícia Costa Pedrosa, Luiza Pereira Reis, Lucas Gabriel Rodrigues Gomes, Vasco Ariston de Carvalho Azevedo, Siomar de Castro Soares
Publikováno v:
Venereology, Vol 3, Iss 3, Pp 120-135 (2024)
Gardnerella vaginalis is a Gram-variable bacillus capable of causing bacterial vaginosis, a condition prevalent in reproductive-age women, this bacterium is present in almost 100% of cases and is also considered a gateway to various sexually transmit
Externí odkaz:
https://doaj.org/article/b57b7692cb224032b9c822512a9a31d4
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-20 (2024)
Abstract Background Delirium and Alzheimer's disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing
Externí odkaz:
https://doaj.org/article/f0549f6d2e3445c6a4f4805b56679577
Autor:
Saloni Mangal, Abhijit Debnath, Rupa Mazumder, Avijit Mazumder, Rajesh Kumar Singh, Jahanvi Sanchitra, S.K. Asif Jan, Pratibha Pandey, Bimlesh Kumar, Anil Kumar Singh
Publikováno v:
All Life, Vol 17, Iss 1 (2024)
Lung cancer is the leading cause of cancer-related deaths globally, accounting for 1.8 million fatalities in 2020. Genetic mutations, chromosomal abnormalities, transcription factors, mutations in tumor suppressor genes, and mutations in oncogenes ha
Externí odkaz:
https://doaj.org/article/5cebcf123ae34675b6b9d8612aa32850