Genomic landscape of drug response reveals mediators of anthelmintic resistance

Autor: Doyle, S.R., Laing, R, Bartley, David, Morrison, A., Holroyd, N., Maitland , K., Antonopoulos, A., Britton, C., Chaudhry, Umer, Flis , I., Howell, S., McIntyre, J., Gilleard, J.S., Tait , A., Mable , B., Kaplan, R., Sargison, Neil, Berriman , M., Devaney, E, Cotton, J.

Publikováno v: Doyle, S R, Laing, R, Bartley, D, Morrison, A, Holroyd, N, Maitland, K, Antonopoulos, A, Britton, C, Chaudhry, U, Flis, I, Howell, S, McIntyre, J, Gilleard, J S, Tait, A, Mable, B, Kaplan, R, Sargison, N, Britton, C, Berriman, M, Devaney, E & Cotton, J 2022, ' Genomic landscape of drug response reveals novel mediators of anthelmintic resistance ', Cell Reports, vol. 41, no. 3, 111522, pp. 1-24 . https://doi.org/10.1016/j.celrep.2022.111522

Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment. Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is key to tracking its spread and improving the efficacy and sustainabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bbd3d76a2889b970a8e1d9c6c57c14
https://doi.org/10.1016/j.celrep.2022.111522

P-glycoproteins play a role in ivermectin resistance in cyathostomins

Autor: J.B. Matthews, Jürgen Krücken, Faith Burden, Gina Pinchbeck, Laura E Peachey, Anne Lespine, G. von Samson-Himmelstjerna, Jane E. Hodgkinson

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 3, Pp 388-398 (2017)
International journal for parasitology. Drugs and drug resistance
International journal for parasitology. Drugs and drug resistance, Elsevier, 2017, 7 (3), pp.388-398. ⟨10.1016/j.ijpddr.2017.10.006⟩
International Journal for Parasitology: Drugs and Drug Resistance
Peachey, L E, Pinchbeck, G L, Matthews, J B, Burden, F A, Lespine, A, von Samson-Himmelstjerna, G, Krücken, J & Hodgkinson, J E 2017, ' P-glycoproteins play a role in ivermectin resistance in cyathostomins ', International Journal for Parasitology: Drugs and Drug Resistance, vol. 7, no. 3, pp. 388-398 . https://doi.org/10.1016/j.ijpddr.2017.10.006
International Journal for Parasitology: Drugs and Drug Resistance 3 (7), 388-398. (2017)

Anthelmintic resistance is a global problem that threatens sustainable control of the equine gastrointestinal cyathostomins (Phylum Nematoda; Superfamily Strongyloidea). Of the three novel anthelmintic classes that have reached the veterinary market

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3580c4abe148c838e611e346abbc1a2
https://doi.org/10.1016/j.ijpddr.2017.10.006

Pharmacological eEF2K activation promotes cell death and inhibits cancer progression

Autor: Olivier Demaria, Léa Zaffalon, Michel Gilliet, Rébecca Panes, Alexey G. Ryazanov, Fabio Martinon, Aude De Gassart

Publikováno v: EMBO reports, vol. 17, no. 10, pp. 1471-1484

Activation of the elongation factor 2 kinase (eEF2K) leads to the phosphorylation and inhibition of the elongation factor eEF2, reducing mRNA translation rates. Emerging evidence indicates that the regulation of factors involved in protein synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb1e85c9b60bac9cf1a20ef3278146d
https://pubmed.ncbi.nlm.nih.gov/27572820

Le concept de « résistance » à l’aspirine : mécanismes et pertinence clinique

Autor: P. Berdagué, Jean-Luc Reny, I. Barazer, Pierre Fontana, P. De Moerloose, Robert F. Bonvini, Jean-Christophe Gris, J.-F. Schved

Publikováno v: Revue de médecine interne, Vol. 30, No 12 (2009) pp. 1020-1029

Aspirin, a 110-year-old molecule, is a cornerstone in the treatment of atherothrombotic patients. The concept of aspirin "resistance" emerged approximately 15 years ago and is of growing interest. Aspirin resistance, defined as a lack of inhibition o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1229221c2ad1637904d917c7fb7a0e2b
https://doi.org/10.1016/j.revmed.2009.02.028

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt

Autor: Sarah K. Volkman, Lise Musset, Eric Legrand, Stanislaw J. Gabryszewski, Dyann F. Wirth, Béatrice Volney, Eli L. Moss, Stéphane Pelleau, Satish K. Dhingra, Daniel E. Neafsey, David A. Fidock, Jessica Casteras

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-7
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩

Comment in : Fusion of field studies and the laboratory solves a puzzle in antimalarial resistance. [Proc Natl Acad Sci U S A. 2015]; International audience; In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f1f82c8002d2b8ac21235f6b72c4a9
https://hal-pasteur.archives-ouvertes.fr/pasteur-01229321/document