Zobrazeno 1 - 10
of 13 083
pro vyhledávání: '"Drug Repurposing"'
Autor:
Marina Esteban-Medina, Víctor Manuel de la Oliva Roque, Sara Herráiz-Gil, María Peña-Chilet, Joaquín Dopazo, Carlos Loucera
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1129-1143 (2024)
We introduce drexml, a command line tool and Python package for rational data-driven drug repurposing. The package employs machine learning and mechanistic signal transduction modeling to identify drug targets capable of regulating a particular disea
Externí odkaz:
https://doaj.org/article/91caf232f7c649bbae3a8cf7b2230cb7
Autor:
Arnob Sarker, Md. Abdul Aziz, Md. Bayazid Hossen, Md. Manir Hossain Mollah, Al-Amin, Md. Nurul Haque Mollah
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Glioblastoma (GBM) is the most malignant brain cancer and one of the leading causes of cancer-related death globally. So, identifying potential molecular signatures and associated drug molecules are crucial for diagnosis and therapies of GBM
Externí odkaz:
https://doaj.org/article/80f63320735546b0ba5ea1f954adf3c1
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract In the realm of epigenetic regulation, Protein arginine deiminase 2 (PAD2) stands out as a therapeutic target due to its significant role in neurological disorders, rheumatoid arthritis (RA), multiple sclerosis (MS), and various cancers. To
Externí odkaz:
https://doaj.org/article/f280e9729b4f41e7a5e07b0123b1a020
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Cancer cells alter their metabolic phenotypes with nutritional change. Single agent approaches targeting mitochondrial metabolism in cancer have failed due to either dose limiting off target toxicities, or lack of significant effi
Externí odkaz:
https://doaj.org/article/9ce6d929c5b04a88953aeb1211941401
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-11 (2024)
Abstract Background Current effective breast cancer treatment options have severe side effects, highlighting a need for new therapies. Drug repurposing can accelerate improvements to care, as FDA-approved drugs have known safety and pharmacological p
Externí odkaz:
https://doaj.org/article/1618fcb0bcd4437e9b0f2a3e7faf1f45
Publikováno v:
Journal of the Egyptian National Cancer Institute, Vol 36, Iss 1, Pp 1-12 (2024)
Abstract Functional genomics, a multidisciplinary subject, investigates the functions of genes and their products in biological systems to better understand diseases and find new drugs. Drug repurposing is an economically efficient approach that enta
Externí odkaz:
https://doaj.org/article/aa86c41aec42463295d7926202a07687
Autor:
Federica Iannelli, Rita Lombardi, Susan Costantini, Maria Serena Roca, Laura Addi, Francesca Bruzzese, Elena Di Gennaro, Alfredo Budillon, Biagio Pucci
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Despite advancements in therapeutic approaches, including taxane-based chemotherapy and androgen receptor-targeting agents, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable tumor, highlighting the need
Externí odkaz:
https://doaj.org/article/6a8ebb7193df4874996367e1308370ea
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Background Chronic inflammation is an increasing global healthcare challenge with limited effective treatment options. Developing medications for chronic diseases requires high financial investment and a long duration. Given these challenges
Externí odkaz:
https://doaj.org/article/9b5affe620c34fb6ab6957cbfac650f7
Autor:
Stephan R. Künzel, Erik Klapproth, Nick Zimmermann, Susanne Kämmerer, Mario Schubert, Karolina Künzel, Maximilian Hoffmann, Stephan Drukewitz, Anne Vehlow, Jiri Eitler, Marieke Arriens, Jessica Thiel, Romy Kronstein-Wiedemann, Maximiliane Tietze, Stefan Beissert, Bertold Renner, Ali El-Armouche, Claudia Günther
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Radiation-induced morphea (RIM) is a rare complication of radiotherapy presenting as inflammatory fibrosis, most commonly reported in breast cancer patients. As underlying disease mechanisms are not well understood, targeted therapies are la
Externí odkaz:
https://doaj.org/article/ca14d9c2e1744a85acf698b849bb68f5
Autor:
Mariana Pereira, Nuno Vale
Publikováno v:
Current Oncology, Vol 31, Iss 10, Pp 6032-6049 (2024)
Ritonavir is a protease inhibitor initially developed for HIV treatment that is now used as a pharmacokinetic booster for other antiretrovirals due to it being a cytochrome P450 3A4 enzyme and P-glycoprotein inhibitor. Consequently, ritonavir is of s
Externí odkaz:
https://doaj.org/article/229e47de07124aaa80061b465555e8db