Zobrazeno 1 - 10
of 1 468
pro vyhledávání: '"Drug Discovery3003 Pharmaceutical Science"'
Autor:
Rosanna Di Paola, Rosalba Siracusa, Enrico Gugliandolo, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Rosalia Crupi, Alessio Filippo Peritore, Salvatore Cuzzocrea
Publikováno v:
Phytomedicine. 54:27-42
Background Myocardial ischemia/reperfusion (I/R) injury is the principal cause of death, happens after prolonged obstruction of the coronary arteries. The first intervention to limit myocardial damage is directed to restoration of perfusion, to avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2750b5c3ca0f0020be423bae0549d09
https://doi.org/10.1016/j.phymed.2018.09.191
https://doi.org/10.1016/j.phymed.2018.09.191
Publikováno v:
Current Opinion in Pharmacology. 47:46-52
HIV-1 infects CD4+ T lymphocytes with a 'helper' function and myeloid cells, mostly tissue-resident macrophages. While infection of CD4 T lymphocytes in the absence of combination antiretroviral therapy (cART) leads to their depletion and to a profou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb26e449a6aa1680e6564488bc5f957f
https://doi.org/10.1016/j.coph.2019.02.006
https://doi.org/10.1016/j.coph.2019.02.006
Autor:
Junfeng Lu, Qiuhe Chen, Shengnan Wang, Simona Rapposelli, Xixin He, Christian Silvio Pomelli, Rongbiao Pi, Grazia Chiellini, Simona Sestito, Simone Bertini
Publikováno v:
European Journal of Medicinal Chemistry. 174:216-225
The identification of a valid therapeutic treatment for Alzheimer's disease (AD) represents nowadays an urgent and still unmet medical need, since currently available anti-AD drugs only relieve symptoms and show a modest efficacy. Recent evidence ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d787936359e8ac6f8ee104d5840cb231
https://doi.org/10.1016/j.ejmech.2019.04.060
https://doi.org/10.1016/j.ejmech.2019.04.060
Autor:
Fatima Margani, Rita Turnaturi, Antonio Rescifina, Loredana Salerno, Valeria Ciaffaglione, Valeria Pittalà, Davide Gentile, Giuseppe Floresta
Publikováno v:
European Journal of Medicinal Chemistry. 167:439-453
Heme oxygenases (HOs) are a family of enzymes involved in the selective catabolism of free circulating heme. While HO-2 is constitutively expressed, HO-1 is strongly overexpressed under stressful stimuli (e.g., oxidative stress). Under these conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef45ee5159a173642e4b84dde276face
https://doi.org/10.1016/j.ejmech.2019.02.027
https://doi.org/10.1016/j.ejmech.2019.02.027
Autor:
Petr Král, Alessio Malfanti, Sabina Pozzi, Anna Balasso, Francesca Mastrotto, Paolo Caliceti, Anna Scomparin, Stefano Salmaso, Yanxiao Han, Ronit Satchi-Fainaro
Publikováno v:
Molecular Pharmaceutics. 16:1678-1693
A novel unconventional supramolecular oligo-cationic structure (Agm6-M-PEG-OCH3) has been synthesized to yield high efficiency therapeutic oligonucleotide (ON) delivery. Agm6-M-PEG-OCH3 was obtaine...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1023e674d21f1bd26c4eb8cd5e8fd1
https://doi.org/10.1021/acs.molpharmaceut.9b00014
https://doi.org/10.1021/acs.molpharmaceut.9b00014
Autor:
Marianna Lauricella, Giuseppe Daidone, Fabiana Plescia, Antonella D'Anneo, Benedetta Maggio, Demetrio Raffa
Publikováno v:
Bioorganic Chemistry. 83:367-379
Based on some common structural features of known compounds interfering with p53 pathways and our previously synthesized benzamides, we synthesized new ethyl 5-(4-substituted benzamido)-1-phenyl-1H-pyrazole-4-carboxylates 26a-c, ethyl 5-(4-substitute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf186f4f519a419ee5524916e15ea6f
https://doi.org/10.1016/j.bioorg.2018.10.055
https://doi.org/10.1016/j.bioorg.2018.10.055
Autor:
Angela Amoresano, Giarita Ferraro, Antonello Merlino, Andrea Pica, Francesca Pane, Julien Furrer, Konrad Kowalski, Ganna Petruk, Daria Maria Monti, Luigi D’Elia
Publikováno v:
ChemMedChem. 14:594-602
The effects of encapsulating the cytotoxic dinuclear trithiolato-bridged arene ruthenium complex [(η6 -p-MeC6 H4 iPr)2 Ru2 (μ2 -S-p-C6 H4 tBu)3 ]Cl (DiRu-1) within the apoferritin (AFt) nanocage were investigated. The DiRu-1-AFt nanocarrier was cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc5615977c80fde3ae5ae2da6b67c56
https://doi.org/10.1002/cmdc.201800805
https://doi.org/10.1002/cmdc.201800805
Publikováno v:
Journal of Molecular Medicine. 97:437-450
Despite human healthcare advances, some microorganisms continuously react evolving new survival strategies, choosing between a commensal fitness and a pathogenic attitude. Many opportunistic microbes are becoming an increasing cause of clinically evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4af01574c6582e29db2640a45f41da6
https://doi.org/10.1007/s00109-019-01752-6
https://doi.org/10.1007/s00109-019-01752-6
Autor:
Deborah Pietrobono, Nicola Petragnani, Vincenza Andrisano, Claudia Martini, Vincenzo Tumiatti, Nibal Betari, Serena Montanari, Simona Daniele, Lara Davani, Angela Nebbioso, Ettore Novellino, F. Frabetti, Barbara Monti, Pasquale Russomanno, Angela De Simone, Andrea Milelli, Federica Sarno, Lucia Altucci, Patrizia Ballerini, Raffaella Casadei, Valeria La Pietra, Mariarosaria Conte, Sabrina Petralla
Publikováno v:
ACS Medicinal Chemistry Letters. 10:469-474
[Image: see text] Several evidence pointed out the role of epigenetics in Alzheimer’s disease (AD) revealing strictly relationships between epigenetic and “classical” AD targets. Based on the reported connection among histone deacetylases (HDAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b9e665bec91eba99b7359b8ff59082
https://doi.org/10.1021/acsmedchemlett.8b00507
https://doi.org/10.1021/acsmedchemlett.8b00507
Autor:
Adriano Barra, Giuseppe Gigli, Yu Shrike Zhang, F. Calabi, Alessandro Polini, Loretta L. del Mercato
Publikováno v:
Drug Discovery Today
Drug discovery today
Drug discovery today
Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery and might ultimately become essential tools for precision therapy. Although many single-organ and interconnected systems have been described, the immune system has been comparatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e46f1c67c34a271d5652acf150fe44
https://doi.org/10.1016/j.drudis.2018.10.003
https://doi.org/10.1016/j.drudis.2018.10.003