Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Drug Discovery | Hot Paper"'
Autor:
Alice Voss, Danuta Kowalczyk, Matthias Krumb, Marcus Peters, Christian Vogel, Albrecht Bufe, Otto Holst, Loreen Immig, Karin Peters, Maximilian Jäger, Till Opatz
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Arabinogalactan, a microheterogeneous polysaccharide occurring in plants, is known for its allergy‐protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b45ace186beb959811f0bbf083f079
https://doi.org/10.1002/chem.202002287
https://doi.org/10.1002/chem.202002287
Autor:
Luka Raguž, Flavio M. Gall, Michael Brand, Andrew Hemphill, Amélie Ritschl, Lei Wang, Remo S. Schmidt, Rainer Riedl, Marcel Kaiser, Jennifer Jelk, Pascal Mäser, Peter Bütikofer, Stefano Agnello, Michael W. W. Adams, Silvia Gazzola
Publikováno v:
Angewandte Chemie (International Ed. in English)
Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio M; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer (2021). Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angewandte Chemie (International ed.), 60(28), pp. 15613-15621. Wiley-VCH 10.1002/anie.202102153
Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio M; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer (2021). Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angewandte Chemie (International ed.), 60(28), pp. 15613-15621. Wiley-VCH 10.1002/anie.202102153
Leucinostatin A is one of the most potent antiprotozoal compounds ever described, but little was known on structure–activity relationships (SAR). We used Trypanosoma brucei as a protozoal model organism to test synthetically modified derivatives, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98212f7c836e4c1d04dadd5ac17bf6a8
https://edoc.unibas.ch/88978/
https://edoc.unibas.ch/88978/
Cystobactamid 507: Concise Synthesis, Mode of Action and Optimization toward More Potent Antibiotics
Autor:
Rolf Müller, Rolf W. Hartmann, Mostafa M. Hamed, Jana Krull, Lorenz Siebenbürger, Sascha Baumann, Katarina Cirnski, Andreas Kirschning, Mark Brönstrup, Walid A. M. Elgaher, Jennifer Herrmann
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany)
Chemistry (Weinheim an Der Bergstrasse, Germany)
Germany
Chemistry (Weinheim an Der Bergstrasse, Germany)
Germany
Lack of new antibiotics and increasing antimicrobial resistance are among the main concerns of healthcare communities nowadays, and these concerns necessitate the search for novel antibacterial agents. Recently, we discovered the cystobactamids—a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea8580c05947bbdd3fb0af2eabbf48c
https://hdl.handle.net/10033/622128
https://hdl.handle.net/10033/622128
Publikováno v:
Angewandte Chemie (International Ed. in English)
The caspase family of cysteine proteases are highly sought‐after drug targets owing to their essential roles in apoptosis, proliferation, and inflammation pathways. High‐throughput screening efforts to discover inhibitors have gained little tract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289e9445e6cd442ff6c619c9aa5535c5
http://europepmc.org/articles/PMC5698726
http://europepmc.org/articles/PMC5698726