Zobrazeno 1 - 10
of 1 182
pro vyhledávání: '"Drug–target interaction"'
Autor:
Yuanyuan Zhang, Yingdong Wang, Chaoyong Wu, Lingmin Zhan, Aoyi Wang, Caiping Cheng, Jinzhong Zhao, Wuxia Zhang, Jianxin Chen, Peng Li
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Identification of drug–target interactions is an indispensable part of drug discovery. While conventional shallow machine learning and recent deep learning methods based on chemogenomic properties of drugs and target proteins ha
Externí odkaz:
https://doaj.org/article/94a5f7836a444e61afbe7e44e93a3a9b
Autor:
Aryan Bhatia, Moolchand Sharma, Eatedal Alabdulkreem, Nuha Alruwais, Muhammad Kashif Saeed, Abdulsamad Ebrahim Yahya
Publikováno v:
Alexandria Engineering Journal, Vol 106, Iss , Pp 721-734 (2024)
Investigating Drug-Target Interactions (DTI) is crucial for drug repositioning and discovery tasks. However, discovering DTIs through experimental approaches is time-consuming and requires substantial financial resources. To address these challenges,
Externí odkaz:
https://doaj.org/article/f6f15c848b6c42c8a2a92a5ec0efa4cc
Autor:
Sina Abdollahi, Darius P. Schaub, Madalena Barroso, Nora C. Laubach, Wiebke Hutwelker, Ulf Panzer, S.øren W. Gersting, Stefan Bonn
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-27 (2024)
Abstract The evaluation of compound-target interactions (CTIs) is at the heart of drug discovery efforts. Given the substantial time and monetary costs of classical experimental screening, significant efforts have been dedicated to develop deep learn
Externí odkaz:
https://doaj.org/article/380b64076bc34143b62f43f36095c6fa
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Drug-target interaction (DTI) prediction plays a pivotal role in drug discovery and drug repositioning, enabling the identification of potential drug candidates. However, most previous approaches often do not fully utilize the com
Externí odkaz:
https://doaj.org/article/17690a3ffb9146cebdb4c1a2f9177a5c
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background: The rise of network pharmacology has led to the widespread use of network-based computational methods in predicting drug target interaction (DTI). However, existing DTI prediction models typically rely on a limited amount of data
Externí odkaz:
https://doaj.org/article/503d7764847e46da97e777c3417f1ede
Autor:
YaPing Wang, ZhiXiang Yin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The study of drug–target interaction plays an important role in the process of drug development. The subject of DTI forecasting has advanced significantly in the last several years, yielding numerous significant research findings and metho
Externí odkaz:
https://doaj.org/article/df5b26ac34ea4eb588b41dc3d0c1c82e
Publikováno v:
Fundamental Research, Vol 4, Iss 4, Pp 715-737 (2024)
Drug discovery is costly and time consuming, and modern drug discovery endeavors are progressively reliant on computational methodologies, aiming to mitigate temporal and financial expenditures associated with the process. In particular, the time req
Externí odkaz:
https://doaj.org/article/abe1d527aa9d49e99689609b6ec50f03
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Identification of potential drug-target interactions (DTIs) with high accuracy is a key step in drug discovery and repositioning, especially concerning specific drug targets. Traditional experimental methods for identifying the DT
Externí odkaz:
https://doaj.org/article/41d2b9645faa4e84976a93bed8273248
Publikováno v:
AIMS Neuroscience, Vol 11, Iss 2, Pp 203-211 (2024)
Obsessive-compulsive disorder (OCD) is a chronic psychiatric disease in which patients suffer from obsessions compelling them to engage in specific rituals as a temporary measure to alleviate stress. In this study, deep learning-based methods were us
Externí odkaz:
https://doaj.org/article/5c6a251affc24b5c900935e12fb05141
Autor:
Shahnawaz Qureshi, Syed Muhammad Zeeshan Iqbal, Asif Ameer, Seppo Karrila, Yazeed Yasin Ghadi, Syed Aziz Shah
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39279- (2024)
Background and Objective: Emerging diseases like Parkinson or Alzheimer's, which are not curable, endanger human mental health and are challenging to research. Drug target interactions (DTI) are pivotal in the screening of candidate drugs and focus o
Externí odkaz:
https://doaj.org/article/3f450007630d4fee8236f13055d4c355