Výsledky vyhledávání - "Drug, Enzyme Inhibitors"

Role of homologous ASP334 and GLU319 in human non-gastric H,K- and Na,K-ATPases in cardiac glycoside binding

Autor: Rossen Radkov, Solange Kharoubi-Hess, Danièle Schaer, Käthi Geering, Jean-Daniel Horisberger, Nikolai N. Modyanov

Publikováno v: Biochemical and Biophysical Research Communications, vol. 356, no. 1, pp. 142-6

Cardiac steroids inhibit Na,K-ATPase and the related non-gastric H,K-ATPase, while they do not interact with gastric H,K-ATPase. Introducing an arginine, the residue present in the gastric H,K-ATPase, in the second extracellular loop at the correspon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a2ea1f58dda6a4087dd8fa3573114
https://doi.org/10.1016/j.bbrc.2007.02.119

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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum

Autor: Jorge Alejandro Palermo, Marie Gompel, Lydia Puricelli, Laurent Meijer, Maryse Leost, Elisa Bal de Kier Joffé, Laura Hernandez Franco

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2004, 14, pp.1703-1707
Bioorganic and Medicinal Chemistry Letters, 2004, 14, pp.1703-1707

Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cb2ee9716c5c686835ec2ff6713867
https://doi.org/10.1016/j.bmcl.2004.01.050

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The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency

Autor: Giuliana Decorti, Alessandra Pontillo, Alberto Tommasini, Luigina De Leo, Sergio Crovella, Annalisa Marcuzzi

Publikováno v: Pediatric research. 70(1)

The shortage of geranylgeranyl-pyrophosphate (GGPP) was associated to an increased IL-1β release in the autoinflammatory syndrome mevalonate kinase deficiency (MKD), a rare inherited disease that has no specific therapy. Farnesyltransferase inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708ee172c86ed347978be312ce6a78a0
https://pubmed.ncbi.nlm.nih.gov/21430599

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Antidepressant phenotype by inhibiting the phospholipase Cβ(1)--protein kinase Cγ pathway in the forced swim test

Autor: Galeotti, Nicoletta, Ghelardini, Carla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______310::5318cbc2db6f6585b07eab5ae3f5bb01
http://hdl.handle.net/2158/586713

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1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta

Autor: Kunick, C., Lauenroth, K., Leost, M., Meijer, L., Lemcke, T.

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2004, 11, pp.413-416
Bioorganic and Medicinal Chemistry Letters, 2004, 11, pp.413-416

Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3beta versus CDK1 inhibitor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::884c3e2eff0f8de3485cc434e53cac27
https://hal.archives-ouvertes.fr/hal-00020128

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