Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.

Autor: Sciacovelli M; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Gonçalves E; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Cambridge CB10 1SD, UK., Johnson TI; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Zecchini VR; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., da Costa AS; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Gaude E; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Drubbel AV; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Theobald SJ; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Abbo SR; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Tran MG; Department of Oncology, Uro-Oncology Research Group, University of Cambridge, Cambridge CB2 0Ql, UK., Rajeeve V; Integrative Cell Signalling and Proteomics, Centre for Haemato-Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Cardaci S; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Foster S; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK., Yun H; Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0XY, UK., Cutillas P; Integrative Cell Signalling and Proteomics, Centre for Haemato-Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Warren A; Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, UK., Gnanapragasam V; Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK., Gottlieb E; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Franze K; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK., Huntly B; Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0XY, UK., Maher ER; Department of Medical Genetics, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Maxwell PH; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Saez-Rodriguez J; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Cambridge CB10 1SD, UK.; RWTH Aachen University, Faculty of Medicine, Joint Research Center for Computational Biomedicine, Aachen 52074, Germany., Frezza C; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK.

Publikováno v: Nature [Nature] 2016 Aug 31; Vol. 537 (7621), pp. 544-547.