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GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Autor: Furber EC; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Hyatt K; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Collins K; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Yu X; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Droz BA; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Holland A; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Friedrich JL; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Wojnicki S; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Konkol DL; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., O'Farrell LS; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Baker HE; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Coskun T; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Scherer PE; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX., Kusminski CM; Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Christe ME; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Sloop KW; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN., Samms RJ; Diabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN.
Publikováno v: Diabetes [Diabetes] 2024 Feb 01; Vol. 73 (2), pp. 292-305.
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4
Akademický článek
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.
Autor: Samms RJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA. Electronic address: samms_ricardo_j@lilly.com., Zhang G; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Division of Endocrinology and Metabolism, Duke University School of Medicine, Durham, NC, USA., He W; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA., Ilkayeva O; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Division of Endocrinology and Metabolism, Duke University School of Medicine, Durham, NC, USA., Droz BA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Bauer SM; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Stutsman C; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Pirro V; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Collins KA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Furber EC; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Coskun T; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Sloop KW; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Brozinick JT; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Newgard CB; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Division of Endocrinology and Metabolism, Duke University School of Medicine, Durham, NC, USA.
Publikováno v: Molecular metabolism [Mol Metab] 2022 Oct; Vol. 64, pp. 101550. Date of Electronic Publication: 2022 Jul 31.
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5
Akademický článek
GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior.
Autor: Samms RJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Cosgrove R; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Snider BM; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Furber EC; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Droz BA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Briere DA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Dunbar J; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Dogra M; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Alsina-Fernandez J; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Borner T; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA., De Jonghe BC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA., Hayes MR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA., Coskun T; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Sloop KW; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Emmerson PJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN., Ai M; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN.
Publikováno v: Diabetes [Diabetes] 2022 Jul 01; Vol. 71 (7), pp. 1410-1423.
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7
Akademický článek
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Autor: Kawai T; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Sun B; ConfometRx, Santa Clara, CA 95054., Yoshino H; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Feng D; ConfometRx, Santa Clara, CA 95054., Suzuki Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan; suzukiysy@chugai-pharm.co.jp kobilka@stanford.edu sloop_kyle_w@lilly.com., Fukazawa M; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Nagao S; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Wainscott DB; Quantitative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Showalter AD; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Droz BA; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Kobilka TS; ConfometRx, Santa Clara, CA 95054., Coghlan MP; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Willard FS; Quantitative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Kawabe Y; Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan., Kobilka BK; ConfometRx, Santa Clara, CA 95054; suzukiysy@chugai-pharm.co.jp kobilka@stanford.edu sloop_kyle_w@lilly.com., Sloop KW; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 suzukiysy@chugai-pharm.co.jp kobilka@stanford.edu sloop_kyle_w@lilly.com.
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 24; Vol. 117 (47), pp. 29959-29967. Date of Electronic Publication: 2020 Nov 11.
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8
Akademický článek
The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis.
Autor: Antonellis PJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Droz BA; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Cosgrove R; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., O'Farrell LS; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Coskun T; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Perfield JW 2nd; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Bauer S; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Wade M; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Chouinard TE; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Brozinick JT; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Adams AC; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA., Samms RJ; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA. Electronic address: samms_ricardo_j@lilly.com.
Publikováno v: Molecular metabolism [Mol Metab] 2019 Dec; Vol. 30, pp. 131-139. Date of Electronic Publication: 2019 Sep 29.
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9
Akademický článek
Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5.
Autor: Farb TB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Adeva M; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Beauchamp TJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Cabrera O; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Coates DA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Meredith TD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Droz BA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Efanov A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Ficorilli JV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Gackenheimer SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Martinez-Grau MA; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Molero V; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Ruano G; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Statnick MA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Suter TM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Syed SK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Toledo MA; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Willard FS; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Zhou X; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Bokvist KB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Barrett DG; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Publikováno v: Endocrinology [Endocrinology] 2017 Nov 01; Vol. 158 (11), pp. 3859-3873.
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10
Akademický článek
Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse.
Autor: Droz BA; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Sneed BL; Ball State University, Muncie, Indiana, United States of America., Jackson CV; Crown Bioscience - Indiana, Indianapolis, Indiana, United States of America., Zimmerman KM; Crown Bioscience - Indiana, Indianapolis, Indiana, United States of America., Michael MD; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Emmerson PJ; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Coskun T; Eli Lilly and Company, Indianapolis, Indiana, United States of America., Peterson RG; Crown Bioscience - Indiana, Indianapolis, Indiana, United States of America.
Publikováno v: PloS one [PLoS One] 2017 Jun 22; Vol. 12 (6), pp. e0179808. Date of Electronic Publication: 2017 Jun 22 (Print Publication: 2017).
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