Výsledky vyhledávání - "Drossard, J."

Akademický článek

New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants

Autor: Platis, D., Drossard, J., Fischer, R., Ma, J.K.-C., Labrou, N.E.

Publikováno v: In Journal of Chromatography A 2008 1211(1):80-89

Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins

Autor: Arfi, Z.A., Hellwig, S., Drossard, J., Fischer, R., Buyel, J.F.

The production of biopharmaceutical proteins in plants requires efficient downstream processing steps that remove impurities such as host cell proteins (HCPs) and adventitious endotoxins produced by bacteria during transient expression. We therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::d4997e44b6c34d8d360204c8dd7c0bcc
https://publica.fraunhofer.de/handle/publica/244662

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From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants

Autor: Sack, M., Rademacher, T., Spiegel, H., Boes, A., Hellwig, S., Drossard, J., Stoger, E., Fischer, R.

The EU Sixth Framework Programme Integrated Project 'Pharma-Planta' developed an approved manufacturing process for recombinant plant-made pharmaceutical proteins (PMPs) using the human HIV-neutralizing monoclonal antibody 2G12 as a case study. In co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::eedf85727c759a0300c08a4477f7f476
https://publica.fraunhofer.de/handle/publica/246042

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Molecular Farming: Innovative Produktion pharmazeutischer Proteine in Pflanzen

Autor: Buyel, J.F., Reimann, A., Drossard, J., Fischer, R.

The release of the pharmaceutical product Elelyso showed that plantderived biopharmaceuticals can compete economically with products from conventional expression systems. Improvements are required in terms of automation, consistency and purification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::5cb224a7cd004e7f24f7ec503bf8421d
https://publica.fraunhofer.de/handle/publica/237124

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GMP issues for recombinant plant-derived pharmaceutical proteins

Autor: Fischer, R., Schillberg, S., Hellwig, S., Twyman, R.M., Drossard, J.

Recombinant proteins can be produced in a diverse array of plant-based systems, ranging from whole plants growing in the soil to plant suspension cells growing in a fully-defined synthetic medium in a bioreactor. When the recombinant proteins are int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::7f0feaa9f2fd64c833468a27a5775c5b
https://publica.fraunhofer.de/handle/publica/228036

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Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies

Autor: Stöger, E., Vaquero, C., Torres, E., Sack, M., Nicholson, L., Drossard, J., Williams, S., Keen, D., Perrin, Y., Christou, P., Fischer, R.

This report describes the stable expression of a medically important antibody in the staple cereal crops rice and wheat. We successfully expressed a single-chain Fv antibody (ScFvT84.66) against carcinoembryonic antigen (CEA), a well characterized tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::c5758b48ab402bcb05e456811e7e5dfd
https://publica.fraunhofer.de/handle/publica/196881

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Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy

Autor: Perrin, Y., Vaquero, C., Gerrard, I., Sack, M., Drossard, J., Stöger, E., Christou, P., Fischer, R.

Field pea (Pisum sativum L.) appears well suited for the production of high-value molecules such as recombinant antibodies, with well-established agricultural practices world-wide and seeds that are easily stored and distributed. In order to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::0213c309b40e393805b37e6488cc63f5
https://publica.fraunhofer.de/handle/publica/198160

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Towards molecular farming in the future: transient protein expression in plants

Autor: Fischer, R., Vaquero-Martin, C., Markus Sack, Drossard, J., Emans, N., Commandeur, U.

Publikováno v: Europe PubMed Central
ResearcherID
Scopus-Elsevier

Molecular farming in plants can be achieved by stable or transient expression of a recombinant protein. Transient expression of recombinant proteins in plants can rapidly provide large amounts of the proteins for detailed characterization. It is fast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::46d7baefb064aab5380504daab1577c5
https://publica.fraunhofer.de/handle/publica/195398

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Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies

Autor: Torres, E., Vaquero, C., Nicholson, L., Sack, M., Stöger, E., Drossard, J., Christou, P., Fischer, R., Perrin, Y.

We investigated the suitability of transformed rice cell lines as a system for the production of therapeutic recombinant antibodies. Expression constructs encoding a single-chain Fv fragment (scFvT84.66, specific for CEA, the carcinoembryonic antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::944943e9ee9414b8da491e968ea69990
https://publica.fraunhofer.de/handle/publica/195396

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