Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Dror S. Shouval"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1488 (2024)
Patients with active ulcerative colitis (UC) display a misalignment of the circadian clock, which plays a vital role in various immune functions. Our aim was to characterize the expression of clock and inflammation genes, and their mutual regulatory
Externí odkaz:
https://doaj.org/article/c6e606d18eed45a7bc7783bf90a5305a
Autor:
Alex Krauthammer, Ilana Weintraub, Ron Shaoul, Raffi Lev-Tzion, Efrat Broide, Michael Wilschanski, Aaron Lerner, Baruch Yerushalmi, Dror S. Shouval, Hussein Shamaly, Yael Haberman-Ziv, Batia Weiss
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Objective and aimInfantile-onset inflammatory bowel disease (IO-IBD), defined as IBD diagnosed at age 2 years or younger, tends to be more severe and refractory to conventional treatment than IBD diagnosed at a later age. However, data about IO-IBD a
Externí odkaz:
https://doaj.org/article/9aed0ed6d30c4e6e89bd1ca1114c6710
Autor:
Mutaz Sultan, Mohammad Adawi, Nitzan Kol, Blake McCourt, Ihda Adawi, Liran Baram, Noa Tal, Lael Werner, Atar Lev, Scott B. Snapper, Ortal Barel, Liza Konnikova, Raz Somech, Dror S. Shouval
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
PurposeReceptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of necroptosis and inflammatory responses. We present the clinical features, genetic analysis and immune work-up of two patients with infantile-onset infl
Externí odkaz:
https://doaj.org/article/9d62de14171e45ad88380c878ee90f4b
Autor:
Oshrat Levi-Galibov, Hagar Lavon, Rina Wassermann-Dozorets, Meirav Pevsner-Fischer, Shimrit Mayer, Esther Wershof, Yaniv Stein, Lauren E. Brown, Wenhan Zhang, Gil Friedman, Reinat Nevo, Ofra Golani, Lior H. Katz, Rona Yaeger, Ido Laish, John A. Porco, Erik Sahai, Dror S. Shouval, David Kelsen, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Expression and activation of Heat shock factor 1 (HSF1) in cancer associated fibroblasts have been associated with protumorigenic functions. Here the authors show that, in a model of colitis-induced colorectal cancer, HSF1 is activated in stromal fib
Externí odkaz:
https://doaj.org/article/e2082e39466448b09082f3deb8fc453c
Autor:
Inbal Farkash, Tali Feferman, Noy Cohen-Saban, Yahel Avraham, David Morgenstern, Grace Mayuni, Natasha Barth, Yaniv Lustig, Liron Miller, Dror S. Shouval, Asaf Biber, Ilya Kirgner, Yishai Levin, Rony Dahan
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110114- (2021)
Summary: Messenger RNA-based vaccines against COVID-19 induce a robust anti-SARS-CoV-2 antibody response with potent viral neutralization activity. Antibody effector functions are determined by their constant region subclasses and by their glycosylat
Externí odkaz:
https://doaj.org/article/049b5eca979b4cdfa21bb6aa2b12feff
Autor:
Yujia Li, Jessica M. Toothaker, Shira Ben-Simon, Lital Ozeri, Ron Schweitzer, Blake T. McCourt, Collin C. McCourt, Lael Werner, Scott B. Snapper, Dror S. Shouval, Soliman Khatib, Omry Koren, Sameer Agnihorti, George Tseng, Liza Konnikova
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Symbiotic microbial colonization through the establishment of the intestinal microbiome is critical to many intestinal functions, including nutrient metabolism, intestinal barrier integrity, and immune regulation. Recent studies suggest that educatio
Externí odkaz:
https://doaj.org/article/ef1c98446f2f4064afe881ca89837ae7
Autor:
Iddo Vardi, Irit Chermesh, Lael Werner, Ortal Barel, Tal Freund, Collin McCourt, Yael Fisher, Marina Pinsker, Elisheva Javasky, Batia Weiss, Gideon Rechavi, David Hagin, Scott B. Snapper, Raz Somech, Liza Konnikova, Dror S. Shouval
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: More than 50 different monogenic disorders have been identified as directly causing inflammatory bowel diseases, typically manifesting in the first years of life. We present the clinical course and immunological work-up of an adult patien
Externí odkaz:
https://doaj.org/article/c1e1776f487b4ec2b2d27b4bf92be93e
Autor:
Lael Werner, Yu Nee Lee, Erez Rechavi, Atar Lev, Baruch Yerushalmi, Galina Ling, Neil Shah, Holm H. Uhlig, Batia Weiss, Raz Somech, Scott B. Snapper, Dror S. Shouval
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD). We have previously reported significant alterations in innate and adaptive immune re
Externí odkaz:
https://doaj.org/article/73bb68229dc247a8a67ae3b9349d8ec7
Autor:
Amlan Biswas, Dror S. Shouval, Alexandra Griffith, Jeremy A. Goettel, Michael Field, Yu Hui Kang, Liza Konnikova, Erin Janssen, Naresh Singh Redhu, Adrian J. Thrasher, Talal Chatila, Vijay K. Kuchroo, Raif S Geha, Luigi D. Notarangelo, Sung-Yun Pai, Bruce H. Horwitz, Scott B. Snapper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, al
Externí odkaz:
https://doaj.org/article/d6407c36dbee4770a2372e3380f5d795
Autor:
Jeremy A. Goettel, Roopali Gandhi, Jessica E. Kenison, Ada Yeste, Gopal Murugaiyan, Sharmila Sambanthamoorthy, Alexandra E. Griffith, Bonny Patel, Dror S. Shouval, Howard L. Weiner, Scott B. Snapper, Francisco J. Quintana
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1318-1329 (2016)
Summary: Existing therapies for inflammatory bowel disease that are based on broad suppression of inflammation result in variable clinical benefit and unwanted side effects. A potential therapeutic approach for promoting immune tolerance is the in vi
Externí odkaz:
https://doaj.org/article/bd474ed541e14d95abfd2e1ea5239614