Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Drong AW"'
Autor:
Shungin, D, Winkler, TW, Croteau-Chonka, DC, Ferreira, T, Locke, AE, Mägi, R, Strawbridge, RJ, Pers, TH, Fischer, K, Justice, AE, Workalemahu, T, Wu, JMW, Buchkovich, ML, Heard-Costa, NL, Roman, TS, Drong, AW, Song, C, Gustafsson, S, Day, FR, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, JC, Scherag, A, Vedantam, S, Wood, AR, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, CT, Schmidt, EM, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg-Gresham, JL, Buyske, S, Demirkan, A, Ehret, GB, Feitosa, MF, Goel, A, Jackson, AU, Johnson, T, Kleber, ME, Kristiansson, K, Mangino, M, Leach, IM, Medina-Gomez, C, Palmer, CD, Pasko, D, Pechlivanis, S, Peters, MJ, Prokopenko, I, Stančáková, A, Sung, YJ, Tanaka, T, Teumer, A, Van Vliet-Ostaptchouk, JV, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, GM, Bandinelli, S, Barrett, A, Bellis, C, Bennett, AJ, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, DB, Caspersen, IH, Clarke, R, Daw, EW, Deelen, J, Deelman, E, Delgado, G, Doney, AS, Eklund, N, Erdos, MR, Estrada, K, Eury, E, Friedrich, N, Garcia, ME, Giedraitis, V, Gigante, B, Go, AS, Golay, A, Grallert, H, Grammer, TB, Gräßler, J, Grewal, J, Groves, CJ, Haller, T, Hallmans, G
Publikováno v:
Nature, vol 518, iss 7538
© 2015, Macmillan Publishers Limited. All rights reserved. Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::50dc9339ac4e995cb572da74bae72ef7
https://escholarship.org/uc/item/1d45t4sg
https://escholarship.org/uc/item/1d45t4sg
Autor:
Cortés-López M; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Chamely P; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Hawkins AG; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Philadelphia, PA, USA., Stanley RF; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Swett AD; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Ganesan S; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Mouhieddine TH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Dai X; Oxford Nanopore Technologies Inc., New York, NY, USA., Kluegel L; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Chen C; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Batta K; Division of Cancer Sciences, The University of Manchester, Manchester, UK., Furer N; Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel., Vedula RS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Beaulaurier J; Oxford Nanopore Technologies Inc., San Francisco, CA, USA., Drong AW; Oxford Nanopore Technologies Inc., New York, NY, USA., Hickey S; Oxford Nanopore Technologies Inc., San Francisco, CA, USA., Dusaj N; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mullokandov G; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Stasiw AM; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Su J; New York Genome Center, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA., Chaligné R; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Juul S; Oxford Nanopore Technologies Inc., New York, NY, USA., Harrington E; Oxford Nanopore Technologies Inc., New York, NY, USA., Knowles DA; New York Genome Center, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA; Department of Computer Science, Columbia University, New York, NY, USA., Potenski CJ; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Wiseman DH; Division of Cancer Sciences, The University of Manchester, Manchester, UK., Tanay A; Weizmann Institute of Science, Department of Computer Science and Applied Mathematics, Rehovot, Israel., Shlush L; Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel., Lindsley RC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ghobrial IM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Taylor J; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, USA., Abdel-Wahab O; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gaiti F; University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada; University of Toronto, Medical Biophysics, Toronto, ON, Canada. Electronic address: federico.gaiti@uhn.ca., Landau DA; New York Genome Center, New York, NY, USA; Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. Electronic address: dlandau@nygenome.org.
Publikováno v:
Cell stem cell [Cell Stem Cell] 2023 Sep 07; Vol. 30 (9), pp. 1262-1281.e8. Date of Electronic Publication: 2023 Aug 14.
Autor:
Makrinou E; Imperial College London, Faculty of Medicine, Institute of Reproductive and Developmental Biology, London, W12 0NN, UK. Electronic address: e.makrinou@ucl.ac.uk., Drong AW; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, OX3 7LF, UK., Christopoulos G; IVF Unit, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, W12 0NN, UK., Lerner A; Imperial College London, Faculty of Medicine, Institute of Reproductive and Developmental Biology, London, W12 0NN, UK., Chapa-Chorda I; Imperial College London, Faculty of Medicine, Institute of Reproductive and Developmental Biology, London, W12 0NN, UK., Karaderi T; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus., Lavery S; IVF Unit, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, W12 0NN, UK., Hardy K; Imperial College London, Faculty of Medicine, Institute of Reproductive and Developmental Biology, London, W12 0NN, UK., Lindgren CM; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, OX3 7LF, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Franks S; Imperial College London, Faculty of Medicine, Institute of Reproductive and Developmental Biology, London, W12 0NN, UK.
Publikováno v:
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2020 Jan 15; Vol. 500, pp. 110611. Date of Electronic Publication: 2019 Oct 07.
Autor:
Rahmioglu N; a Wellcome Centre for Human Genetics, University of Oxford , Roosevelt Drive, Oxford , OX3 7BN , UK., Drong AW; a Wellcome Centre for Human Genetics, University of Oxford , Roosevelt Drive, Oxford , OX3 7BN , UK., Lockstone H; a Wellcome Centre for Human Genetics, University of Oxford , Roosevelt Drive, Oxford , OX3 7BN , UK., Tapmeier T; b Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology , John Radcliffe Hospital, University of Oxford , Oxford , OX3 7BN , UK., Hellner K; b Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology , John Radcliffe Hospital, University of Oxford , Oxford , OX3 7BN , UK., Saare M; c Competence Centre on Health Technologies, Tartu, Estonia and Women's Clinic, Institute of Clinical Medicine, University of Tartu , Tartu , Estonia., Laisk-Podar T; c Competence Centre on Health Technologies, Tartu, Estonia and Women's Clinic, Institute of Clinical Medicine, University of Tartu , Tartu , Estonia., Dew C; b Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology , John Radcliffe Hospital, University of Oxford , Oxford , OX3 7BN , UK., Tough E; b Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology , John Radcliffe Hospital, University of Oxford , Oxford , OX3 7BN , UK., Nicholson G; a Wellcome Centre for Human Genetics, University of Oxford , Roosevelt Drive, Oxford , OX3 7BN , UK., Peters M; c Competence Centre on Health Technologies, Tartu, Estonia and Women's Clinic, Institute of Clinical Medicine, University of Tartu , Tartu , Estonia., Morris AP; a Wellcome Centre for Human Genetics, University of Oxford , Roosevelt Drive, Oxford , OX3 7BN , UK.; d Department of Biostatistics , University of Liverpool , Liverpool , OX3 7BN , UK., Lindgren CM; a Wellcome Centre for Human Genetics, University of Oxford , Roosevelt Drive, Oxford , OX3 7BN , UK., Becker CM; b Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology , John Radcliffe Hospital, University of Oxford , Oxford , OX3 7BN , UK., Zondervan KT; a Wellcome Centre for Human Genetics, University of Oxford , Roosevelt Drive, Oxford , OX3 7BN , UK.; b Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology , John Radcliffe Hospital, University of Oxford , Oxford , OX3 7BN , UK.
Publikováno v:
Epigenetics [Epigenetics] 2017; Vol. 12 (10), pp. 897-908. Date of Electronic Publication: 2017 Nov 27.
Autor:
Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK. b.lehne@imperial.ac.uk., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Institute of Health Sciences, University of Oulu, P.O.Box 5000, Oulu, FI-90014, Finland., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Tan ST; Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK., Schulz R; Division of Genetics and Molecular Medicine, King's College London, London, UK., Scott J; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Institute of Health Sciences, University of Oulu, P.O.Box 5000, Oulu, FI-90014, Finland.; Biocenter Oulu, University of Oulu, P.O.Box 5000, Aapistie 5A, Oulu, FI-90014, Finland.; Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220, Oulu, 90029 OYS, Finland.; Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101, Oulu, Finland., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK., Kooner JS; Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK. j.chambers@imperial.ac.uk.; Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK. j.chambers@imperial.ac.uk.; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK. j.chambers@imperial.ac.uk.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK. j.chambers@imperial.ac.uk.
Publikováno v:
Genome biology [Genome Biol] 2016 Apr 21; Vol. 17, pp. 73. Date of Electronic Publication: 2016 Apr 21.
Autor:
Kilpeläinen TO; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.; Genetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Carli JF; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA., Skowronski AA; Institute of Human Nutrition, Columbia University, New York, New York 10032, USA., Sun Q; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachussetts 02115, USA., Kriebel J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany., Feitosa MF; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Hedman ÅK; Science for Life Laboratory, Uppsala University, Uppsala 750 85, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Hayes JE; Cell and Developmental Biology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Zhao J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Pers TH; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachussetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark., Schick U; Genetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark., Kutalik Z; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden 2333, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333, The Netherlands., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; National Institute for Health Research Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London SE1 9RT, UK., Kristiansson K; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland., Beekman M; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere FI-33101, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere FI-33014, Finland., Eriksson J; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Henneman P; Department of Human Genetics, Leiden University Medical Center, Leiden 2333, The Netherlands.; Department of Clinical Genetics, Amsterdam Medical Center, Amsterdam 1081 HV, The Netherlands., Lahti J; Institute of Behavioural Sciences, University of Helsinki, Helsinki FI-00014, Finland.; Folkhälsan Research Center, Helsinki FI-00290, Finland., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Del Greco M F; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 20502, Sweden.; Department of Biobank Research, Umeå University, Umeå 90187, Sweden., Willems SM; Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA., Guo X; Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California 90502, USA., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Kleber ME; Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Mannheim 68167, Germany., Pérusse L; Department of Kinesiology, Laval University, Quebec City, Quebec, Canada G1V 0A6.; Institute of Nutrition and Functional Foods, Quebec City, Quebec, Canada G1V 0A6., Gaunt T; MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK., Ahluwalia TS; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Ledreborg Allé, Copenhagen DK-2820, Denmark.; Steno Diabetes Center, Gentofte DK-2820, Denmark., Ju Sung Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Ramos YF; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands., Amuzu A; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Barroso I; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.; The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Bellis C; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore 138672, Singapore.; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4001, Australia.; Texas Biomedical Research Institute, San Antonio, Texas 78245, USA., Blangero J; Texas Biomedical Research Institute, San Antonio, Texas 78245, USA., Buckley BM; Department of Pharmacology and Therapeutics, University College Cork, Cork T12 YT57, Ireland., Böhringer S; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., I Chen YD; Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California 90502, USA., de Craen AJ; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333, The Netherlands., Crosslin DR; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.; Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA., Dale CE; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Dastani Z; Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 0G4., Day FR; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Deelen J; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Delgado GE; Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Mannheim 68167, Germany., Demirkan A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden 2333, The Netherlands., Finucane FM; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK., Garcia ME; National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 2089, USA., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Gustafsson S; Science for Life Laboratory, Uppsala University, Uppsala 750 85, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 751 85, Sweden., Hallmans G; Department of Biobank Research, Umeå University, Umeå 90187, Sweden., Hankinson SE; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA.; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA., Havulinna AS; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Herder C; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany., Hernandez D; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy., Hunter DJ; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.; Institute for Human Genetics, Hannover Medical School, Hannover 30625, Germany., Ingelsson E; Science for Life Laboratory, Uppsala University, Uppsala 750 85, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Ioan-Facsinay A; Department of Rheumatology, Leiden University Medical Center, Leiden 2333, The Netherlands., Jansson JO; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg 41345, Sweden., Jenny NS; Laboratory for Clinical Biochemistry Research, Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester, Vermont 05405, USA., Jørgensen ME; Steno Diabetes Center, Gentofte DK-2820, Denmark., Jørgensen T; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup 2600, Denmark.; Faculty of Medicine, University of Aalborg, Aalborg 9100, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark., Karlsson M; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedic Surgery, Lund University, Skåne University Hospital, Malmö 21428, Sweden., Koenig W; Department of Internal Medicine II - Cardiology, University of Ulm, Ulm 89081, Germany.; Deutsches Herzzentrum München, Technische Universität München, Munich 80636, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich 80539, Germany., Kraft P; Department of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachussetts 02115, USA., Kwekkeboom J; Department of Rheumatology, Leiden University Medical Center, Leiden 2333, The Netherlands., Laatikainen T; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio FI-70211, Finland.; Hospital District of North Karelia, Joensuu FI-80210, Finland., Ladwig KH; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Klinikum Rechts der Isar, Technische Universität München, Munich 81675, Germany., LeDuc CA; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York 10029, USA., Lowe G; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Lu Y; Genetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Marques-Vidal P; Department of Internal Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland., Meisinger C; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Myers RH; Department of Neurology, Boston University School of Medicine, Boston, Massachussetts 02118, USA., Männistö S; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA., Paternoster L; MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich 80539, Germany., Pradhan AD; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA.; Harvard Medical School, Boston, Massachussetts 02115, USA., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA., Rasmussen-Torvik LJ; Preventive Medicine, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA., Rathmann W; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany., Rice TK; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Brent Richards J; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Department of Medicine, Human Genetics and Epidemiology, McGill University, Montreal, Quebec, Canada H3A 0G4., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA.; Harvard Medical School, Boston, Massachussetts 02115, USA., Sattar N; Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow G12 8QQ, UK., Savage DB; The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Söderberg S; Department of Public Health and Clinical Medicine, Cardiology and Heart Centre, Umeå University, Umeå 90187, Sweden., Timpson NJ; MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK., Vandenput L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., van Heemst D; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333, The Netherlands., Uh HW; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Vohl MC; Institute of Nutrition and Functional Foods, Quebec City, Quebec, Canada G1V 0A6.; School of Nutrition, Laval University, Quebec City, Quebec, Canada G1V 0A6., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 7RU, UK., Wichmann HE; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern, Munich 80336, Germany.; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich 81675, Germany., Widén E; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Yao J; Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California 90502, USA., Zeller T; German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Hamburg 20246, Germany.; Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany., Zhang Y; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York 10029, USA., Meulenbelt I; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Kloppenburg M; Department of Rheumatology, Leiden University Medical Center, Leiden 2333, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2333, The Netherlands., Astrup A; Faculty of Science, Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen 1165, Denmark., Sørensen TI; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.; MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen 2000, Denmark., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA., Rao DC; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Jousilahti P; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Vartiainen E; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Hofman A; Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands., Rivadeneira F; Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam 3015 GE, The Netherlands., Uitterlinden AG; Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam 3015 GE, The Netherlands., Kajantie E; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki FI-00014, Finland.; Department of Obstetrics and Gynaecology, MRC Oulu, Oulu University Central Hospital and University of Oulu, Oulu 90220, Finland., Osmond C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK., Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland.; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.; Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Eriksson JG; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.; Folkhälsan Research Center, Helsinki FI-00290, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki FI-00014, Finland., Heliövaara M; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Knekt PB; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Koskinen S; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Jula A; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland., Perola M; Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland.; University of Tartu, Estonian Genome Centre, Tartu 51010, Estonia., Huupponen RK; Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku FI-20520, Finland.; Unit of Clinical Pharmacology, Turku University Hospital, Turku FI-20520, Finland., Viikari JS; Division of Medicine, Turku University Hospital, Turku FI-20520, Finland.; Department of Medicine, University of Turku, Turku FI-20520, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere FI-33521, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere FI-33014, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere FI-33101, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere FI-33014, Finland., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku FI-2051, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku FI-20520, Finland., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Lorentzon M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Casas JP; Farr Institute of Health Informatics, University College London, London NW1 2DA, UK., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze, Florence 50122, Italy., März W; Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Mannheim 68167, Germany.; Synlab Academy, Synlab Services LLC, Mannheim 68161, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8010, Austria., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands., van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden 2333, The Netherlands., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.; Center of Medical Systems Biology, Leiden 2300 RC, The Netherlands., Harris TB; Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, Maryland 20892, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA., Allison MA; Family and Preventive Medicine, University of California-San Diego, La Jolla, California 92161, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA.; Harvard Medical School, Boston, Massachussetts 02115, USA., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.; Department of Neurology, General Central Hospital, Bolzano 39100, Italy.; Department of Neurology, University of Lübeck, Lübeck 23562, Germany., Borecki IB; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Waterworth DM; GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA., Bergmann S; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1015, Switzerland., Waeber G; Department of Internal Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland., Vollenweider P; Department of Internal Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland., Vestergaard H; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.; Steno Diabetes Center, Gentofte DK-2820, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense 5230, Denmark., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark., Hu FB; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA., Eline Slagboom P; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Grallert H; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden 2333, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands, Utrecht 3511 EP, The Netherlands.; Durrer Center for Cardiogenetic Research, Amsterdam 1105 AZ, The Netherlands., Klein RJ; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Schadt EE; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Franks PW; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachussetts 02115, USA.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 20502, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå 90187, Sweden., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachussetts 02142, USA.; The Big Data Institute, University of Oxford, Oxford OX1 2JD, UK., Leibel RL; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York 10029, USA., Loos RJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.; Genetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Publikováno v:
Nature communications [Nat Commun] 2016 Feb 01; Vol. 7, pp. 10494. Date of Electronic Publication: 2016 Feb 01.
Autor:
Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Gustafsson S; Science for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden., Buchkovich ML; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Na J; Department of Developmental and Regenerative Biology, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Bataille V; West Herts NHS Trust, Herts HP2 4AD, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Cousminer DL; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland., Dastani Z; Department Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Esko T; Estonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Evans DM; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited., Falchi M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Hedman ÅK; Science for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Haring R; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; European University of Applied Sciences, Faculty of Applied Public Health, 18055 Rostock, Germany., Hysi PG; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Iles MM; Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK., Lagou V; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK., Li R; Department Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2., Li X; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Locke A; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Lu C; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Mägi R; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Estonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia., Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge 02142, USA.; Department of Epidemiology Research, Statens Serum Institut, 2100 Copenhagen, Denmark., Qi Q; Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA., Sanna M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK., Schmidt EM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Shungin D; Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, 901 87 Umeå, Sweden.; Department of Odontology, Umeå University, 901 85 Umeå, Sweden., Teumer A; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany., Vinkhuyzen AA; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia., Walker RW; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Westra HJ; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02446, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02446, USA., Zhang M; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Zhu Z; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Ahluwalia TS; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sceinces, University of Copenhagen, 2200 Copenhagen, Denmark.; Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, 2200 Copenhagen, Denmark.; Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark., Bakker SJ; University of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands., Bellis C; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA., Bonnefond A; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, 59000 Lille, France.; Université de Lille 2, 59000 Lille, France., Borodulin K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA., Cederholm T; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 85 Uppsala, Sweden., Choh AC; Lifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA., Choi HJ; Department of Anatomy, Seoul National University College of Medicine, Seoul 03080, Korea., Curran JE; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520., de Groot LC; Department of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands., De Jager PL; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA.; Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Dhonukshe-Rutten RA; Department of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands., Enneman AW; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Eury E; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, 59000 Lille, France.; Université de Lille 2, 59000 Lille, France., Evans DS; California Pacific Medical Center Research Institute, San Francisco, California 94107, USA., Forsen T; Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Fumeron F; INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.; Univ Paris Diderot, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA., Gärtner S; Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany., Han BG; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea., Havulinna AS; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Hernandez D; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Hillege H; University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands., Ittermann T; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Kent JW; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA., Kolcic I; Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia., Laatikainen T; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Hospital District of North Karelia, FI-80210 Joensuu, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, FI-70211 Kuopio, Finland., Lahti J; Folkhälsan Research Centre, FI-00290 Helsinki, Finland.; Institute of Behavioural Sciences, University of Helsinki, FI-00014 Helsinki, Finland., Mateo Leach I; University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands., Lee CG; Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.; Research Service, Veterans Affairs Medical Center, Portland, Oregon 97239, USA., Lee JY; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea., Liu T; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, 14195 Berlin, Germany.; Max Planck Institute for Human Development, 14194 Berlin, Germany., Liu Y; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA., Lobbens S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, 59000 Lille, France.; Université de Lille 2, 59000 Lille, France., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore 138648, Singapore., Lyytikäinen LP; Department of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, FI-33520 Tampere, Finland., Medina-Gomez C; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Michaëlsson K; Department of Surgical Sciences, Orthopedics, Uppsala University, 751 85 Uppsala, Sweden., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Nielson CM; School of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.; Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA., Oozageer L; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Pascoe L; Institute of Cell &Molecular Biosciences, Newcastle University, Newcastle NE1 7RU, UK., Paternoster L; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited., Polašek O; Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Ripatti S; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.; Hjelt Institute, University of Helsinki, FI-00014 Helsinki, Finland., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA., Shin CS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea., Narančić NS; Institute for Anthropological Research, Zagreb 10000, Croatia., Spira D; The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.; Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany., Srikanth P; School of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.; Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA., Steinhagen-Thiessen E; The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.; Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Swart KM; EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.; VUMC, Department of Epidemiology and Biostatistics, 1081 BT Amsterdam, The Netherlands., Taittonen L; Department of Pediatrics, University of Oulu, FI-90014 Oulu, Finland.; Department of Pediatrics, Vaasa Central Hospital, FI-65100 Vaasa, Finland., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Tikkanen E; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.; Hjelt Institute, University of Helsinki, FI-00014 Helsinki, Finland., van der Velde N; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., van Schoor NM; EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.; VUMC, Department of Epidemiology and Biostatistics, 1081 BT Amsterdam, The Netherlands., Verweij N; University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA., Zmuda JM; Department of Epidemiology; University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA., Eklund N; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Forrester T; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark., Jackson AU; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kristiansson K; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kuulasmaa T; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Kuusisto J; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.; Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.; Kuopio University Hospital, 70029 Kuopio, Finland., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Männistö S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Palmer CD; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Stancáková A; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland., Wagner PJ; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Demirkan A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands., Döring A; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Faculty of Medicine, Reykjavik 101, Iceland., Kiel DP; Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.; Institute for Aging Research Hebrew Senior Life, Boston, Massachusetts 02131, USA., Kühnel B; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Mcknight B; Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.; Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., O'Connell JR; Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands., Shuldiner AR; Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21042, USA., Song K; Genetics, Projects Clinical Platforms and Sciences, GlaxoSmithKline, Philadelphia, Pennsylvania 19112, USA., Vandenput L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden., van Duijn CM; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.; Center for Medical Systems Biology, 2300 Leiden, The Netherlands., Vollenweider P; Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland., White CC; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Boehnke M; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Boettcher Y; University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.; University of Leipzig, Department of Medicine, 04103 Leipzig, Germany., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Grallert H; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Hingorani A; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Jørgensen T; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Faculty of Medicine, University of Aalborg, 9220 Aalborg, Denmark.; Research Centre for Prevention and Health, DK2600 Capital Region of Denmark, Denmark., Jousilahti P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kivimaki M; Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK., Kumari M; Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK., Laakso M; Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.; Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.; Kuopio University Hospital, 70029 Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK., Linneberg A; Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark., Luke A; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA., Mckenzie CA; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica., Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.; Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts 02114, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA., Bertram L; School of Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK.; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, 23562 Lübeck, Germany., Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520., Blüher M; University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.; University of Leipzig, Department of Medicine, 04103 Leipzig, Germany., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Cho NH; Ajou University School of Medicine, Department of Preventive Medicine, Suwon Kyoung-gi 443-721, Korea., Cummings SR; California Pacific Medical Center Research Institute, San Francisco, California 94107, USA., Czerwinski SA; Lifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA., Demuth I; The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany., Eckardt R; The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany., Eriksson JG; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland.; Folkhälsan Research Centre, FI-00290 Helsinki, Finland., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Franco OH; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Froguel P; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, 59000 Lille, France.; Université de Lille 2, 59000 Lille, France., Gansevoort RT; University of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA., Hastie N; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Heliövaara M; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Hofman A; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Jordan JM; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA., Jula A; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, FI-33014 Tampere, Finland., Kajantie E; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Children's Hospital, Helsinki University Hospital and University of Helsinki, FI-00029 Helsinki, Finland.; Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, FI-90029 Oulu, Finland., Knekt PB; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Koskinen S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kovacs P; University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany., Lehtimäki T; Department of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, FI-33520 Tampere, Finland., Lind L; Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Orwoll ES; Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA., Osmond C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK., Perola M; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.; Estonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Pérusse L; Department of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6.; Institute of Nutrition and Functional Foods, Laval University, Québec City, Quebec, Canada G1V 0A6., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA., Rao DC; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Rice TK; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Rivadeneira F; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Sørensen TI; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, 2000 Frederiksberg, Denmark., Stumvoll M; University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.; University of Leipzig, Department of Medicine, 04103 Leipzig, Germany., Tönjes A; University of Leipzig, Department of Medicine, 04103 Leipzig, Germany., Towne B; Lifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA., Tranah GJ; California Pacific Medical Center Research Institute, San Francisco, California 94107, USA., Tremblay A; Department of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Vartiainen E; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Viikari JS; Department of Medicine, University of Turku, FI-20521 Turku, Finland., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Vohl MC; Institute of Nutrition and Functional Foods, Laval University, Québec City, Quebec, Canada G1V 0A6.; School of Nutrition, Laval University, Québec City, Quebec, Canada G1V 0A6., Völzke H; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany.; DZD (German Centre for Diabetes Research), partner site Greifswald, 17475 Greifswald, Germany., Walker M; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.; Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK., Wallaschofski H; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany., Wild S; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Yengo L; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, 59000 Lille, France.; Université de Lille 2, 59000 Lille, France., Bishop DT; Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK., Borecki IB; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.; Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA., Dehghan A; Department of Epidemiology, Erasmus Medical Center, 3000CA Rotterdam/Zuidholland, The Netherlands., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia., Fatemifar G; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited., Fox C; Harvard Medical School, Boston, Massachusetts 02115, USA.; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA., Furey TS; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Franke L; University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Han J; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA., Hunter DJ; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Karjalainen J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.; Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK., Kaplan RC; Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA., Kooner JS; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK.; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.; Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK., Murabito JM; Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA.; NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Bishop JA; Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK., North KE; Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Unit for Lifelong Health and Ageing at UCL, London WC1B 5JU, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK., Richards JB; Department Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.; Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.; Department of Twin Research, King's College London, London SE1 1E7, UK.; Division of Endocrinology, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2., Schadt EE; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Widén E; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland., Willer CJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA., Yang J; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia., Ingelsson E; Science for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Hirschhorn JN; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Pospisilik JA; Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, D-76108 Freiburg, Germany., Zillikens MC; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands., Lindgren C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.; The Big Data Institute, University of Oxford, Oxford OX3 7LJ, UK., Kilpeläinen TO; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Publikováno v:
Nature communications [Nat Commun] 2016 Feb 01; Vol. 7, pp. 10495. Date of Electronic Publication: 2016 Feb 01.
Autor:
Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Loh M; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (ASTAR), Singapore., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wang X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK., Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Saleheen D; Center for Non-Communicable Diseases, Karachi, Pakistan.; Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.; Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Leach IM; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Abbott J; Bioinformatics Support Service, Imperial College London, London, UK., Wahl S; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Tan ST; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Campanella G; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Chadeau-Hyam M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK., Ahluwalia TS; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center, Gentofte, Denmark., Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Chen P; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Edwards TL; Vanderbilt Epidemiology Center, Center for Human Genetics Research, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA., Go MJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Harris SE; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and Medical Research Council (MRC) Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Hartiala J; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.; Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Kasela S; Estonian Genome Center, University of Tartu, Tartu, Estonia., Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Khor CC; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore, ASTAR, Singapore.; Department of Ophthalmology, National University of Singapore, Singapore.; Department of Paediatrics, National University of Singapore, Singapore., Kleber ME; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany., Li H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Yu Mok Z; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Nakatochi M; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan., Sapari NS; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Saxena R; Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Stewart AFR; University of Ottawa Heart Institute, Cardiovascular Research Methods Centre, Ottawa, Ontario, Canada.; Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada., Stolk L; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Teh AL; Singapore Institute for Clinical Sciences (SICS), ASTAR, Singapore., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan., Zhang Y; State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hypertension, Shanghai, China., Aits I; Institute of Epidemiology and Biobank popgen, Christian Albrechts University of Kiel, Kiel, Germany., Da Silva Couto Alves A; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Das S; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Dorajoo R; Genome Institute of Singapore, ASTAR, Singapore., Hopewell JC; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Kim YK; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Koivula RW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Nguyen QN; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam., Pereira MA; School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Postmus I; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Scannell Bryan M; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Sorice R; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy., Tragante V; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.; Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) 'Burlo Garofolo', Trieste, Italy., White J; University College London Genetics Institute, Department of Genetics, Environment and Evolution, University College London, London, UK., Yamamoto K; Division of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Zhang Y; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA., Ahmed A; UChicago Research Bangladesh, Uttara, Dhaka, Bangladesh., Akiyama K; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Asif R; Center for Non-Communicable Diseases, Karachi, Pakistan., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Barroso I; Metabolic Disease Group, Wellcome Trust Sanger Institute, Cambridge, UK.; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Bjonnes A; Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Braun TR; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Cai H; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan., Cheng CY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore., Chong YS; Singapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Collins R; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Courtney R; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA., Davies G; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Delgado G; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany., Do LD; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam., Doevendans PA; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Gansevoort RT; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Gao YT; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Grammer TB; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany., Grarup N; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grewal J; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK., Gu D; Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Wander GS; Dayanand Medical College and Hospital Unit, Hero DMC Heart Institute, Ludhiana, India., Hartikainen AL; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Center, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Hazen SL; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., He J; Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, Singapore., Hixson JE; Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas, USA., Hofman A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Hsu C; University of Southern California Keck School of Medicine, Los Angeles, California, USA., Huang W; Department of Genetics, Chinese National Human Genomic Center, Shanghai, China., Husemoen LLN; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark., Hwang JY; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Ichihara S; Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan., Igase M; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Isono M; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Justesen JM; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan., Kibriya MG; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA., Kim YJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Kishimoto M; National Center for Global Health and Medicine, Toyama, Japan., Koh WP; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Duke-National University of Singapore Graduate Medical School, Singapore., Kohara K; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK., Kwek K; K.K. Women's and Children's Hospital, Singapore., Lee NR; University of San Carlos Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines., Lee J; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Liao J; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Lieb W; Institute of Epidemiology and Biobank popgen, Christian Albrechts University of Kiel, Kiel, Germany., Liewald DCM; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Matsubara T; Department of Internal Medicine, Aichi-Gakuin University School of Dentistry, Nagoya, Japan., Matsushita Y; National Center for Global Health and Medicine, Toyama, Japan., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mills R; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, Ludwig Maximilians University Munich, Munich, Germany.; German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany., Nabika T; Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan., Nakashima E; Division of Endocrinology and Diabetes, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Diabetes and Endocrinology, Chubu Rosai Hospital, Nagoya, Japan., Ng HK; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Nikus K; Heart Centre, Department of Cardiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland., Nutile T; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy., Ohkubo T; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan., Ohnaka K; Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Parish S; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Paternoster L; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Peng H; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany., Pham ST; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam., Pinidiyapathirage MJ; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Rahman M; UChicago Research Bangladesh, Uttara, Dhaka, Bangladesh.; Research and Evaluation Division, Bangladesh Rehabilitation Assistance Committee (BRAC), Dhaka, Bangladesh., Rakugi H; Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan., Rolandsson O; Department of Public Health and Clinical Medicine, Section for Family Medicine, Umeå Universitet, Umeå, Sweden., Ann Rozario M; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Ruggiero D; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy., Sala CF; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy., Sarju R; Dayanand Medical College and Hospital Unit, Hero DMC Heart Institute, Ludhiana, India., Shimokawa K; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sparsø T; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Spiering W; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Starr JM; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK., Stott DJ; Academic Section of Geriatric Medicine, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK., Stram DO; University of Southern California Keck School of Medicine, Los Angeles, California, USA., Sugiyama T; Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan., Szymczak S; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany., Tang WHW; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Tong L; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Turjanmaa V; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland., Ueshima H; Department of Health Science, Shiga University of Medical Science, Otsu, Japan.; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Umemura S; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Vaarasmaki M; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.; Medical Research Center, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., van Gilst WH; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van Veldhuisen DJ; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Viikari JS; Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Medicine, University of Turku, Turku, Finland., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Wang Y; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Wang A; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China., Wilson R; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Wong TY; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Xiang YB; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Yamaguchi S; Third Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan., Ye X; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Young RD; Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Young TL; Neuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, Singapore.; Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA., Yuan JM; Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA., Zhou X; Bioinformatics Division, Tsinghua National Laboratory for Informatics Science and Technology (TNLIST), Ministry of Education Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.; Center for Synthetic and Systems Biology, TNLIST, Ministry of Education Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.; Department of Psychiatry, University of Hong Kong, Hong Kong., Asselbergs FW; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands (ICIN)-Netherlands Heart Institute, Utrecht, the Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Ciullo M; Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy., Clarke R; Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Deloukas P; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; King Abdulaziz University, Jeddah, Saudi Arabia., Franke A; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Public Health and Clinical Medicine, Section for Family Medicine, Umeå Universitet, Umeå, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA., Franks S; Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, UK., Friedlander Y; Hebrew University, School of Public Health, Jerusalem, Israel., Gross MD; School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Guo Z; Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China., Hansen T; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jarvelin MR; Institute of Health Sciences, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland., Jørgensen T; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands (ICIN)-Netherlands Heart Institute, Utrecht, the Netherlands.; ICIN, Utrecht, the Netherlands., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland., Kajio H; National Center for Global Health and Medicine, Toyama, Japan., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Lee JY; Ministry of Health and Welfare, Seoul, Republic of Korea.; THERAGEN ETEX Bio Institute, Suwon, Republic of Korea., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Linneberg A; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Miki T; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Pedersen O; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK., Sørensen TIA; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Takayanagi R; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan., Toniolo D; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.; Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy., Ahsan H; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA., Allayee H; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.; Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Deary IJ; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Heijman BT; Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Holbrook JD; Singapore Institute for Clinical Sciences (SICS), ASTAR, Singapore., Isaacs A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Kim BJ; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea., Lin X; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Liu J; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore, ASTAR, Singapore., März W; Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; Synlab Academy, Synlab Services, Mannheim, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Sanghera DK; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA., van Meurs JBJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Vithana E; Department of Ophthalmology, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Neuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, Singapore., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wolffenbuttel BHW; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Yokota M; Department of Genome Science, Aichi-Gakuin University School of Dentistry, Nagoya, Japan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA., Zhu D; State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Hypertension, Shanghai, China., Vineis P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Kyrtopoulos SA; National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece., Kleinjans JCS; Department of Toxicogenomics, Maastricht University, Maastricht, the Netherlands., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK., Soong R; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Department of Pathology, National University of Singapore, Singapore., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Scott J; National Heart and Lung Institute, Imperial College London, London, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore, ASTAR, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; National University of Singapore Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands (ICIN)-Netherlands Heart Institute, Utrecht, the Netherlands., Kooner JS; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.; Imperial College Healthcare NHS Trust, London, UK.
Publikováno v:
Nature genetics [Nat Genet] 2015 Nov; Vol. 47 (11), pp. 1282-1293. Date of Electronic Publication: 2015 Sep 21.
Autor:
Karaderi T; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK. tugce.karaderi@well.ox.ac.uk., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK. alexd@well.ox.ac.uk., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Oxford, UK. celi@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. celi@broadinstitute.org.; Big Data Institute, University of Oxford, Oxford, UK. celi@broadinstitute.org.
Publikováno v:
Current diabetes reports [Curr Diab Rep] 2015 Oct; Vol. 15 (10), pp. 83.