Tau local structure shields an amyloid-forming motif and controls aggregation propensity.

Autor: Chen D; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Drombosky KW; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Hou Z; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Sari L; Green Center for Molecular, Computational and Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Kashmer OM; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Ryder BD; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Perez VA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Woodard DR; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Lin MM; Green Center for Molecular, Computational and Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Diamond MI; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Joachimiak LA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Lukasz.Joachimiak@utsouthwestern.edu.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Lukasz.Joachimiak@utsouthwestern.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Jun 07; Vol. 10 (1), pp. 2493. Date of Electronic Publication: 2019 Jun 07.

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.

Autor: Sahoo B; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America., Arduini I; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America., Drombosky KW; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America., Kodali R; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America., Sanders LH; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America., Greenamyre JT; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America., Wetzel R; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, United States of America.

Publikováno v: PloS one [PLoS One] 2016 Jun 06; Vol. 11 (6), pp. e0155747. Date of Electronic Publication: 2016 Jun 06 (Print Publication: 2016).

Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2).

Autor: Song GJ; From the Department of Pharmacology and Chemical Biology, Department of Pharmacology, Brain Science and Engineering Institute, School of Medicine, Kungpook National University, Daegu 702-701, Korea, and., Leslie KL; From the Department of Pharmacology and Chemical Biology., Barrick S; From the Department of Pharmacology and Chemical Biology., Mamonova T; From the Department of Pharmacology and Chemical Biology., Fitzpatrick JM; Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755., Drombosky KW; From the Department of Pharmacology and Chemical Biology., Peyser N; From the Department of Pharmacology and Chemical Biology., Wang B; From the Department of Pharmacology and Chemical Biology., Pellegrini M; Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755., Bauer PM; Vascular Medicine Institute, and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260., Friedman PA; From the Department of Pharmacology and Chemical Biology., Mierke DF; Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755., Bisello A; From the Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, and alb138@pitt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 Jan 30; Vol. 290 (5), pp. 2879-87. Date of Electronic Publication: 2014 Dec 09.

β-hairpin-mediated nucleation of polyglutamine amyloid formation.

Autor: Kar K; Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Hoop CL, Drombosky KW, Baker MA, Kodali R, Arduini I, van der Wel PC, Horne WS, Wetzel R

Publikováno v: Journal of molecular biology [J Mol Biol] 2013 Apr 12; Vol. 425 (7), pp. 1183-97. Date of Electronic Publication: 2013 Jan 23.