Single whole genome sequencing analysis blazes the trail for precision medicine

Autor: Giulia C. Napoli, Cindy H. Chau, William D. Figg

Publikováno v: Cancer Biology & Therapy, Vol 23, Iss 1, Pp 134-135 (2022)

As precision oncology evolves toward developing more targeted therapies, sequencing has moved to the forefront of treatment decision-making. Whole genome sequencing (WGS) has emerged as a technology capable of identifying candidates for rare and targ

Externí odkaz: https://doaj.org/article/a561b63df72d4859a45f54d1faaada74

Prognostic Significance of Gene Signature of Tertiary Lymphoid Structures in Patients With Lung Adenocarcinoma

Autor: Hong Feng, Fujun Yang, Lihong Qiao, Kai Zhou, Junfei Wang, Jiao Zhang, Tian Tian, Ying Du, Hong Shangguan

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

BackgroundLung adenocarcinoma (LUAD) is a highly mortal cancer. Tertiary lymphoid structures (TLS) are ectopic lymphoid organs with similar morphological and molecular characters to secondary lymphoid organ. The aim of this study is to investigate th

Externí odkaz: https://doaj.org/article/7a9d0f17d41a4194a3664e66ed7885c4

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Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability

Autor: Agathe Guilloux, Sylvie Job, Nabila Elarouci, Olivier Buhard, Alex Duval, Thierry André, Lucile Armenoult, Mira Ayadi, Florence Coulet, Malorie Greene, Erell Guillerm, Anastasia R. Goloudina, Pascale Cervera, Toky Ratovomanana, Alain Virouleau, Samuel Landman, Yann Parc, Romane Bertrand, Vincent Jonchère, Aurélien de Reyniès, Magali Svrcek, Jérémie H. Lefevre, Sylvie Dumont, Fatiha Merabtene, Jean-François Fléjou, Laetitia Marisa, Ada Collura

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 277-300 (2018)

Background & Aims Recent studies have shown that cancers arise as a result of the positive selection of driver somatic events in tumor DNA, with negative selection playing only a minor role, if any. However, these investigations were concerned with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5077b4453b4c0cd703fc1ded2c75175
https://doi.org/10.1016/j.jcmgh.2018.06.002

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