Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

Autor: Pauline Scholler, Damien Nevoltris, Dimitri de Bundel, Simon Bossi, David Moreno-Delgado, Xavier Rovira, Thor C. Møller, Driss El Moustaine, Michaël Mathieu, Emilie Blanc, Heather McLean, Elodie Dupuis, Gérard Mathis, Eric Trinquet, Hervé Daniel, Emmanuel Valjent, Daniel Baty, Patrick Chames, Philippe Rondard, Jean-Philippe Pin

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the

Externí odkaz: https://doaj.org/article/816648732d614ed3bfb0746f18dd9438

Prion Protein Aggregation Induced by Copper(II) and Heparan Sulfate. Pressure-dependent Switch of Reaction Pathways

Autor: Joan Torrent, Reinhard Lange, Driss El Moustaine

Publikováno v: Zeitschrift fur Naturforschung B
Zeitschrift fur Naturforschung B, Verlag der Zeitschrift Fuer Naturforschung, 2008, 63, pp.747-755. ⟨10.1515/znb-2008-0624⟩

Copper ions (Cu2+) and heparan sulfate (HS) are suspected to act as regulatory agents in the conversion of cellular prion protein (PrPC) to its infectious isoform. However, the mechanism of this reaction is still largely unknown. Our previous report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ba1e6c8fbb26cc8c54ce28284e2fe6
https://doi.org/10.1515/znb-2008-0624