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pro vyhledávání: '"Drinkenburg P"'
Akademický článek
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Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106309- (2023)
In humans, social factors (e.g., loneliness) have been linked to the risk of developing Alzheimer's Disease (AD). To date, AD pathology is primarily characterized by amyloid-β plaques and tau tangles. We aimed to assess the effect of single- and gro
Externí odkaz:
https://doaj.org/article/9a738b6db94542e6ab8353697ca35c14
Autor:
S. Tok, H. Maurin, C. Delay, D. Crauwels, N. V. Manyakov, W. Van Der Elst, D. Moechars, W. H. I. M. Drinkenburg
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-23 (2022)
Abstract The two main histopathological hallmarks that characterize Alzheimer’s Disease are the presence of amyloid plaques and neurofibrillary tangles. One of the current approaches to studying the consequences of amyloid pathology relies on the u
Externí odkaz:
https://doaj.org/article/bf962d0ae2cc44cd8650ad03d6bc01a5
Autor:
S. Tok, H. Maurin, C. Delay, D. Crauwels, N. V. Manyakov, W. Van Der Elst, D. Moechars, W. H. I. M. Drinkenburg
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-22 (2022)
Abstract Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by two main pathological hallmarks: amyloid plaques and intracellular tau neurofibrillary tangles. However, a majority of studies focus on the individual pathologies and
Externí odkaz:
https://doaj.org/article/f7866d207ed846e29816b80de0927231
Autor:
Simon Loiodice, Wilhelmus H. Drinkenburg, Abdellah Anhaou, Andrew McCarthy, Geoffrey Viardot, Emilie Cayre, Bertrand Rion, Valérie Bertaina-Anglade, Marsel Mano, Philippe L’Hostis, Christophe Drieu La Rochelle, Martien J. Kas, Philippe Danjou
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The lack of translation from basic research into new medicines is a major challenge in CNS drug development. The need to use novel approaches relying on (i) patient clustering based on neurobiology irrespective to symptomatology and (ii) qua
Externí odkaz:
https://doaj.org/article/02e869dbbb484613b0f92bbde6bae585
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
A. Ahnaou, D. Rodriguez-Manrique, S. Embrechts, R. Biermans, N. V. Manyakov, S. A. Youssef, W. H. I. M. Drinkenburg
Publikováno v:
Neural Plasticity, Vol 2020 (2020)
The aging process eventually cause a breakdown in critical synaptic plasticity and connectivity leading to deficits in memory function. The olfactory bulb (OB) and the hippocampus, both regions of the brain considered critical for the processing of o
Externí odkaz:
https://doaj.org/article/f5774b2d144549bfb075454a1d8308a7
Publikováno v:
Neural Plasticity, Vol 2020 (2020)
Broad issues associated with non-replicability have been described in experimental pharmacological and behavioral cognitive studies. Efforts to prevent biases that contribute to non-replicable scientific protocols and to improve experimental rigor fo
Externí odkaz:
https://doaj.org/article/5dd2972cacf84bc18bcba4d1566d69d8
Autor:
A. Ahnaou, D. Moechars, L. Raeymaekers, R. Biermans, N. V. Manyakov, A. Bottelbergs, C. Wintmolders, K. Van Kolen, T. Van De Casteele, J. A. Kemp, W. H. Drinkenburg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD), preceding clear changes in histopathology and cognitive functioning. Here, the early and late effects of tau pathology induction on functional network
Externí odkaz:
https://doaj.org/article/a9c5148746e4437dbedab4ea4cfaf87c
Autor:
Cathalijn H. C. Leenaars, W. H. Pim Drinkenburg, Christ Nolten, Maurice Dematteis, Ruud N. J. M. A. Joosten, Matthijs G. P. Feenstra, Rob B. M. De Vries
Publikováno v:
Journal of Circadian Rhythms, Vol 17, Iss 1 (2019)
Sleep seems essential to proper functioning of the prefrontal cortex (PFC). The role of different neurotransmitters has been studied, mainly the catecholamines and serotonin. Less attention has been paid to the amino acid transmitters and histamine.
Externí odkaz:
https://doaj.org/article/fb3e1445d49a49bc872004faa9652f04