Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Dries Van den Bossche"'
Autor:
Sergio A. Alonso de Diego, Daniel Oehlrich, Harrie J.M. Gijsen, Andrés A. Trabanco, Hana Prokopcová, Nigel Austin, Michel Surkyn, Dries Van den Bossche, Frederik J. R. Rombouts, Deborah Dhuyvetter, Gregor James Macdonald, Sven Franciscus Anna Van Brandt, Herman Borghys, Michiel Van Gool, Diederik Moechars, Aránzazu García-Molina, Michel Anna Jozef De Cleyn, Carolina Martinez-Lamenca
Publikováno v:
Journal of Medicinal Chemistry. 61:5292-5303
In previous studies, the introduction of electron withdrawing groups to 1,4-oxazine BACE1 inhibitors reduced the pKa of the amidine group, resulting in compound 2 that showed excellent in vivo efficacy, lowering Aβ levels in brain and CSF. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82fa110d3c2cadb8d001203f372949b
https://doi.org/10.1021/acs.jmedchem.8b00304
https://doi.org/10.1021/acs.jmedchem.8b00304
Autor:
Ewoud De Gussem, Sam Pieters, Johan Van der Eycken, Wouter A. Herrebout, Patrick Bultinck, Dries Van den Bossche, Jelle Cornelus
Publikováno v:
ChemPhysChem: a European journal of chemical physics and physical chemistry
The absolute configuration of 5-(3-bromophenyl)-4-hydroxy-5-methylhexan-2-one, an intermediate in the synthesis of various natural products, is assigned by using vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and optical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700f13c19125255c0ff856109b36ffa4
https://pubmed.ncbi.nlm.nih.gov/23943592
https://pubmed.ncbi.nlm.nih.gov/23943592