Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dries De Clercq"'
Autor:
Min Wu, Ulderico Di Caprio, Furkan Elmaz, Bert Metten, Dries De Clercq, Olivier Van Der Ha, Siegfried Mercelis, Peter Hellinckx, Leen Braeken, M. Enis Leblebici
Publikováno v:
32nd European Symposium on Computer Aided Process Engineering
Computer Aided Chemical Engineering ISBN: 9780323958790
Computer Aided Chemical Engineering ISBN: 9780323958790
This study investigated two artificial intelligence techniques, Swarm Intelligence(SI) and Artificial Neural Networks(ANN), aiming to overcome the difficulties of simulating complex processes with unknown reactions and intermediates. These techniques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986cc3efb12951c7ba3d05ed5925691a
https://hdl.handle.net/10067/1942270151162165141
https://hdl.handle.net/10067/1942270151162165141
Autor:
Bo Hee Shin, Dries De Clercq, Charles M. Ponthier, Jaebong Jang, Nathanael S. Gray, Ciric To, Radosław P. Nowak, Pasi A. Jänne, Eric S. Fischer, Eun Young Park, Michael J. Eck, Mierzhati Mushajiang
Publikováno v:
Angew Chem Int Ed Engl
Targeting epidermal growth factor receptor (EGFR) through an allosteric mechanism provides a potential therapeutic strategy to overcome drug-resistant EGFR mutations that emerge within the ATP binding site. Here, we develop an allosteric EGFR degrade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d89bbbd0e883d285550c1187d06323d
https://europepmc.org/articles/PMC7686272/
https://europepmc.org/articles/PMC7686272/
Autor:
Jamie A. Saxon, Michael J. Eck, Pasi A. Jänne, T. Kosaka, Jieun Son, Eun Young Park, Hwan Geun Choi, Nathanael S. Gray, Dries De Clercq, Jaebong Jang, Junko Tanizaki
Publikováno v:
Angewandte Chemie International Edition. 57:11629-11633
Exon 20 insertion (Ex20Ins) mutations are the third most prevalent epidermal growth factor receptor (EGFR) activating mutation and the most prevalent HER2 mutation in non-small cell lung cancer (NSCLC). Novel therapeutics for the patients with Ex20In
Autor:
Ranie Kellens, Hugo Klaassen, Javier del Pino Garcia, Mathieu Bollen, Sandro Boland, Matthias Versele, Ilse Vandecaetsbeek, Arnaud Marchand, Patrick Chaltin, Arnaud Pierre Jean Bourin, Dries De Clercq, Wanda Haeck, Sara Allasia, Karolien Castermans
Publikováno v:
Cancer Research. 81:53-53
Extracellular 2',3'-cyclic GMP-AMP (cGAMP) has a critical immune-transmitter role in the tumor microenvironment (TME). Tumor cells produce and secrete cGAMP, which primes immune cells for tumor rejection through STING (stimulator of interferon genes)
Autor:
David E. Heppner, Cai-Hong Yun, Nathanael S. Gray, Ciric To, Michael J. Eck, Dries De Clercq, Bo Hee Shin, Pasi A. Jänne, Mierzhati Mushajiang, David A. Scott, Jaebong Jang, Thomas W. Gero, Eun Young Park
Publikováno v:
ACS Med Chem Lett
[Image: see text] Allosteric kinase inhibitors represent a promising new therapeutic strategy for targeting kinases harboring oncogenic driver mutations in cancers. Here, we report the discovery, optimization, and structural characterization of allos
Autor:
Bo Hee Shin, Michael D. Cameron, Thomas W. Gero, Michael J. Eck, Man Xu, Kwok-Kin Wong, Stephen Wang, Annan Yang, Ciric To, Jaebong Jang, Mierzhati Mushajiang, Suzanne E. Dahlberg, Eun Young Park, Ting Chen, David E. Heppner, Pasi A. Jänne, Nathanael S. Gray, Dries De Clercq
Publikováno v:
Cancer Discov
Allosteric kinase inhibitors offer a potentially complementary therapeutic strategy to ATP-competitive kinase inhibitors due to their distinct sites of target binding. In this study, we identify and study a mutant-selective EGFR allosteric inhibitor,
Autor:
Karolien De Bosscher, Leentje De Ceuninck, Delphine Masschaele, Veronic De Puysseleyr, Ioanna Petta, Virginie Vauthier, Serge Van Calenbergh, Irma Lemmens, Dries De Clercq, Sam Lievens, Dieter Defever, Marc Vidal, Jan Tavernier, Anne-Sophie De Smet, Sven Eyckerman, Claude Libert, José Van der Heyden, Surya Gupta, Lennart Martens, Nele Vanderroost, David E. Hill
Because proteins are the main mediators of most cellular processes they are also prime therapeutic targets. Identifying physical links among proteins and between drugs and their protein targets is essential in order to understand the mechanisms throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d947acc16eff444690022291f3d3bb23
https://europepmc.org/articles/PMC5141276/
https://europepmc.org/articles/PMC5141276/
Autor:
Davy Sinnaeve, José C. Martins, Martijn D. P. Risseeuw, Ulrik Hillaert, Sam Lievens, Freya Van den Broeck, Serge Van Calenbergh, Jan Tavernier, Dries De Clercq
Publikováno v:
Chemmedchem
We present a scalable synthesis of a versatile MTX reagent with an azide ligation handle that allows rapid γ-selective conjugation to yield MTX fusion compounds (MFCs) appropriate for MASPIT, a three-hybrid system that enables the identification of
Publikováno v:
ACS chemical biology. 11(8)
The identification of the molecular targets and mechanisms underpinning the beneficial or detrimental effects of small-molecule leads and drugs constitutes a crucial aspect of current drug discovery. Over the last two decades, three-hybrid (3H) syste
Autor:
Jan Tavernier, Sam Lievens, Serge Van Calenbergh, Anne-Sophie De Smet, Dieter Defever, Izet Karalic, Martijn D. P. Risseeuw, Dries De Clercq
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(5)
We report the evaluation of two alternative chemical dimerizer approaches aimed at increasing the sensitivity of MASPIT, a three-hybrid system that enables small-molecule target protein profiling in intact human cells. To circumvent the potential lim