Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Drielli Gomes Vital Fujii"'
Autor:
Drielli Gomes Vital Fujii
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Doenças causadas por agentes infecciosos e parasitários são chamadas negligenciadas por não despertarem interesse das indústrias farmacêuticas para o desenvolvimento de novas alternativas terapêuticas. Essas doenças são responsáveis por lev
Autor:
Gustavo Henrique Goulart Trossini, Renan Augusto Gomes, Elys Juliane Cardoso Lima, Drielli Gomes Vital-Fujii, Amanda Luisa da Fonseca, Fernando de Pilla Varotti, Alex Guterres Taranto, Fernando de Moura Gatti
Publikováno v:
Future Medicinal Chemistry. 13:233-250
Malaria is still a life-threatening public health issue, and the upsurge of resistant strains requires continuous generation of active molecules. In this work, 35 sulfonylhydrazone derivatives were synthesized and evaluated against Plasmodium falcipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b6bdb97948406590891788d9f86fa99
https://doi.org/10.4155/fmc-2020-0229
https://doi.org/10.4155/fmc-2020-0229
Autor:
Fernando de, Moura Gatti, Renan Augusto, Gomes, Amanda Luisa, da Fonseca, Elys Juliane, Cardoso Lima, Drielli Gomes, Vital-Fujii, Alex Guterres, Taranto, Fernando de, Pilla Varotti, Gustavo Henrique, Goulart Trossini
Publikováno v:
Future medicinal chemistry. 13(3)
Malaria is still a life-threatening public health issue, and the upsurge of resistant strains requires continuous generation of active molecules. In this work, 35 sulfonylhydrazone derivatives were synthesized and evaluated against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9191ef49eddb312bbc723e61d4db77b
https://pubmed.ncbi.nlm.nih.gov/33295837
https://pubmed.ncbi.nlm.nih.gov/33295837
Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases
Autor:
Juliana da Fonseca Rezende e Mello, Drielli Gomes Vital-Fujii, Gustavo Henrique Goulart Trossini, Glaucio Monteiro Ferreira, Renan Augusto Gomes
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Neglected diseases (NDs) affect large populations and almost whole continents, representing 12% of the global health burden. In contrast, the treatment available today is limited and sometimes ineffective. Under this scenery, the Fragment-Based Drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25da6e8a526bc9b3fdc98802acd4173
https://doi.org/10.1111/cbdd.13030
https://doi.org/10.1111/cbdd.13030
Autor:
Drielli Gomes Vital Fujii, Márcia Dalastra Laurenti, Glaucio Monteiro Ferreira, Cristiano Raminelli, Gustavo Henrique Goulart Trossini, Luiz Felipe Domingues Passero, Adriana Bezerra-Souza, Etyene J. G. Silva
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Aim: Considering the epidemiology of leishmaniasis, the emergence of resistant parasites to the approved drugs, and severe clinical manifestations, the development of novel leishmanicidal molecules has become of considerable importance. Results: In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0ae6ab1377e84082210606a085680d
https://pubmed.ncbi.nlm.nih.gov/30066582
https://pubmed.ncbi.nlm.nih.gov/30066582
Autor:
Evandro Italo Macêdo de Souza, Marcelo Santos Castilho, Suellen Gonçalves da Silva, Drielli Gomes Vital-Fujii, Thamires Quadros Froes, Samuel Silva da Rocha Pita, Gustavo Henrique Goulart Trossini, Franco Henrique Andrade Leite
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Despite the fact that Leishmania ssp are pteridine auxotrophs, Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) inhibitors are ineffective against Leishmania major. On the other hand Pteridine Reductase 1 (PTR1) inhibitors proved to be lethal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d634f82e04cf7b7ad24f8212ef6f4cd0
https://pubmed.ncbi.nlm.nih.gov/28407565
https://pubmed.ncbi.nlm.nih.gov/28407565
Autor:
Gustavo Henrique Goulart Trossini, Drielli Gomes Vital Fujii, Luis P. B. Scott, Káthia Maria Honório, Simone Queiroz Pantaleão, Danielle da Costa Silva, Karen C. Weber, Vinícius Gonçalves Maltarollo
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Background Due to the increasing number of diabetes cases worldwide, there is an international concern to provide even more effective treatments to control this condition. Methods This review brings together a selection of studies that helped to broa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f17e7e00f9b5b6632e0dc0e43adcf3
https://pubmed.ncbi.nlm.nih.gov/28530546
https://pubmed.ncbi.nlm.nih.gov/28530546