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The evolutionary history of 2,658 cancers

Autor: Gerstung, M., Jolly, C., Leshchiner, I., Dentro, S.C., Gonzalez, S., Rosebrock, D., Mitchell, T.J., Rubanova, Y., Anur, P., Yu, K., Tarabichi, M., Deshwar, A.G., Wintersinger, J., Kleinheinz, K., Vázquez-García, I., Haase, K., Jerman, L., Sengupta, Subhajit, Macintyre, G., Malikic, S., Donmez, N., Livitz, D.G., Cmero, M., Demeulemeester, J., Schumacher, S., Fan, Y., Yao, X., Lee, J., Schlesner, M., Boutros, P.C., Bowtell, D.D., Zhu, H., Getz, G., Imielinski, M., Beroukhim, R., Sahinalp, S.C., Ji, Y., Peifer, M., Markowetz, F., Mustonen, V., Yuan, K., Wang, W., Morris, Q.D., Adams, D.J., Campbell, P.J., Cao, S., Christie, E.L., Cun, Y., Dawson, K.J., Drews, R.M., Eils, R., Fittall, M., Garsed, D.W., Ha, G., Lee-Six, H., Martincorena, I., Oesper, L., Peto, M., Raphael, B.J., Salcedo, A., Sengupta, S., Shi, R., Shin, S.J., Spiro, O., Stein, L.D., Vembu, S., Wheeler, D.A., Yang, T.-P., Spellman, P.T., Wedge, D.C., Van Loo, P.

Publikováno v: Nature, vol 578, iss 7793
Nature, 578, 122-128
Nature
Nature, 578, 7793, pp. 122-128
Gerstung, M, Jolly, C, Leshchiner, I, Dentro, S C, Gonzalez, S, Rosebrock, D, Mitchell, T J, Rubanova, Y, Anur, P, Yu, K, Tarabichi, M, Deshwar, A G, Wintersinger, J, Kleinheinz, K, Vázquez-García, I, Haase, K, Jerman, L, Sengupta, S, Macintyre, G, Malikic, S, Donmez, N, Livitz, D G, Cmero, M, Demeulemeester, J, Schumacher, S, Fan, Y, Yao, X, Lee, J, Schlesner, M, Boutros, P C, Bowtell, D D, Zhu, H, Getz, G, Imielinski, M, Beroukhim, R, Sahinalp, S C, Ji, Y, Peifer, M, Markowetz, F, Mustonen, V, Yuan, K, Wang, W, Morris, Q D, Dentro, S C, Leshchiner, I, Gerstung, M, Jolly, C, Haase, K, Tarabichi, M, Wintersinger, J, Deshwar, A G, Yu, K, Gonzalez, S, Rubanova, Y, Macintyre, G, Adams, D J, Anur, P, Beroukhim, R, Boutros, P C, Bowtell, D D, Campbell, P J, Cao, S, Christie, E L, Cmero, M, Cun, Y, Dawson, K J, Donmez, N, Drews, R M, Eils, R, Fan, Y, Fittall, M, Garsed, D W, Getz, G, Ha, G, Imielinski, M, Jerman, L, Ji, Y, Kleinheinz, K, Lee, J, Lee-Six, H, Livitz, D G, Malikic, S, Markowetz, F, Martincorena, I, Mitchell, T J, Mustonen, V, Oesper, L, Peifer, M, Peto, M, Raphael, B J, Rosebrock, D, Sahinalp, S C, Salcedo, A, Schlesner, M, Schumacher, S, Sengupta, S, Shi, R, Shin, S J, Spiro, O, Stein, L D, Vázquez-García, I, Vembu, S, Wheeler, D A, Yang, T-P, Yao, X, Yuan, K, Zhu, H, Wang, W, Morris, Q D, Spellman, P T, Wedge, D C, Van Loo, P, Spellman, P T & Wedge, D C 2020, ' The evolutionary history of 2,658 cancers ', Nature, vol. 578, no. 7793, pp. 122-128 . https://doi.org/10.1038/s41586-019-1907-7

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a891fdaa058cb17c6b08024ab762a118
https://hdl.handle.net/2066/288694

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Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Autor: Rubanova, Y., Shi, R., Harrigan, C.F., Li, R., Wintersinger, J., Sahin, N., Deshwar, A.G., Dentro, S.C., Leshchiner, I., Gerstung, M., Jolly, C., Haase, K., Tarabichi, M., Yu, K., Gonzalez, S., Macintyre, G., Adams, D.J., Anur, P., Beroukhim, R., Boutros, P.C., Bowtell, D.D., Campbell, P.J., Cao, S., Christie, E.L., Cmero, M., Cun, Y., Dawson, K.J., Demeulemeester, J., Donmez, N., Drews, R.M., Eils, R., Fan, Y., Fittall, M., Garsed, D.W., Getz, G., Ha, G., Imielinski, M., Jerman, L., Ji, Y., Kleinheinz, K., Lee, J., Lee-Six, H., Livitz, D.G., Malikic, S., Markowetz, F., Martincorena, I., Mitchell, T.J., Mustonen, V., Oesper, L., Peifer, M., Peto, M., Raphael, B.J., Rosebrock, D., Sahinalp, S.C., Salcedo, A., Schlesner, M., Schumacher, S., Sengupta, Subhajit, Shin, S.J., Spiro, O., Stein, L.D., Vázquez-García, I., Vembu, S., Wheeler, D.A., Yang, T.-P., Yao, X., Yuan, K., Zhu, H., Wang, W., Morris, Q., Spellman, P.T., Wedge, D.C., Van Loo, P.

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Rubanova, Y, Shi, R, Harrigan, C F, Li, R, Wintersinger, J, Sahin, N, Deshwar, A G, Dentro, S C, Leshchiner, I, Gerstung, M, Jolly, C, Haase, K, Tarabichi, M, Wintersinger, J, Deshwar, A G, Yu, K, Gonzalez, S, Rubanova, Y, Macintyre, G, Adams, D J, Anur, P, Beroukhim, R, Boutros, P C, Bowtell, D D, Campbell, P J, Cao, S, Christie, E L, Cmero, M, Cun, Y, Dawson, K J, Demeulemeester, J, Donmez, N, Drews, R M, Eils, R, Fan, Y, Fittall, M, Garsed, D W, Getz, G, Ha, G, Imielinski, M, Jerman, L, Ji, Y, Kleinheinz, K, Lee, J, Lee-Six, H, Livitz, D G, Malikic, S, Markowetz, F, Martincorena, I, Mitchell, T J, Mustonen, V, Oesper, L, Peifer, M, Peto, M, Raphael, B J, Rosebrock, D, Sahinalp, S C, Salcedo, A, Schlesner, M, Schumacher, S, Sengupta, S, Shi, R, Shin, S J, Spiro, O, Stein, L D, Vázquez-García, I, Vembu, S, Wheeler, D A, Yang, T-P, Yao, X, Yuan, K, Zhu, H, Wang, W, Morris, Q, Spellman, P T, Wedge, D C, Van Loo, P & Morris, Q 2020, ' Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-020-14352-7
Nature communications, vol 11, iss 1
Nature Communications, 11, 1
Nature Communications, 11

The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a7b2ac966978d66edf7db35efa1679

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