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Molecular imaging of monocarboxylate transporters with PET – development and biological evaluation of novel 2-fluoropyridinyl analogs of FACH

Autor: Sadeghzadeh, M., Deuther-Conrad, W., Wenzel, B., Gündel, D., Toussaint, M., Moldovan, R.-P., Fischer, S., Ludwig, F.-A., Teodoro, R., Jonnalagadda, S., Jonnalagadda, S. K., Mereddy, V. R., Drewes, L. R., Brust, P.

Publikováno v: 33rd Annual Congress of the European Association of Nuclear Medicine (EANM-2020), 17.-21.10.2020, Vienna, AustriaEuropean Journal of Nuclear Medicine and Molecular Imaging 47(2020), S11-S12

Introduction Monocarboxylate transporters 1-4 (MCT1-4) are involved in several metabolism-related diseases, especially cancer, providing the chance to be considered as relevant targets for diagnosis and therapy. Recently, we reported on [18F]FACH as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::bade23d6c8575856c6b99c0caea3fb2d
https://www.hzdr.de/publications/Publ-31062-1

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Development of novel analogs of the monocarboxylate transporter ligand FACH and biological validation of one potential radiotracer for PET imaging

Autor: Sadeghzadeh, M., Wenzel, B., Gündel, D., Deuther-Conrad, W., Toussaint, M., Moldovan, R.-P., Fischer, S., Teodoro, R., Jonnalagadda, S., Jonnalagadda, S. K., Mereddy, V. R., Drewes, L. R., Brust, P.

Publikováno v: Molecules 25(2020)10, 2309

Monocarboxylate transporters 1-4 (MCT1-4) are involved in several metabolism-related diseases, especially cancer, providing the chance to be considered as relevant targets for diagnosis and therapy. [18F]FACH was recently developed and showed very pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::ee8881ba47d57cf7875c79ca5858c87b
https://www.hzdr.de/publications/Publ-30853-1

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Development of the first 18F-labeled MCT1/MCT4 lactate transport inhibitor: Radiosynthesis and preliminary in vivo evaluation in mice

Autor: Sadeghzadeh, M., Moldovan, R.-P., Wenzel, B., Kranz, M., Deuther-Conrad, W., Toussaint, M., Fischer, S., Ludwig, F.-A., Teodoro, R., Gurrapu, S., Drewes, L. R., Brust, P.

Publikováno v: 23rd International Symposium on Radiopharmaceutical Sciences (ISRS2019), 26.-31.05.2019, Beijing, China

Objectives: Although, lactate is occasionally considered as a waste in physiological cell metabolism, it is also known as an important substrate that fuels the oxidative metabolism of oxygenated tumor cells. Therefore, tumor cells express a set of pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::90b5cbe0523cd1a272b5cc3044acb71d
https://www.hzdr.de/publications/Publ-28208-1

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Radiosynthesis and preliminary biological evaluation of a novel 18F-labeled MCT1/MCT4 inhibitor for tumor imaging by PET

Autor: Sadeghzadeh, M., Moldovan, R.-P., Wenzel, B., Deuther-Conrad, W., Toussaint, M., Fischer, S., Ludwig, F.-A., Teodoro, R., Kranz, M., Spalholz, T., Gurrapu, S., Steinbach, J., Drewes, L. R., Brust, P.

Publikováno v: 26. Jahrestagung Arbeitsgemeinschaft Radiochemie und Radiopharmazie (AGRR2018), 20.-22.09.2018, Aachen, Deutschland

Aim: Monocarboxylate transporters (MCTs) are integral plasma membrane proteins that bi-directionally transport lactate and ketone bodies and are highly expressed in non-hypoxic regions of human colon, brain, breast, lung and other tumors.[1] Transpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::de70d038e1a3e8b717762ba6bd5887e7
https://www.hzdr.de/publications/Publ-28210-1

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Synthesis and radiofluorination of a novel monocarboxylate transporter 1 inhibitor for tumor imaging by PET

Autor: Sadeghzadeh, M., Moldovan, R.-P., Wenzel, B., Fischer, S., Teodoro, R., Ludwig, F.-A., Gurrapu, S., Drewes, L. R., Brust, P.

Publikováno v: 18th Radiochemical Conference, 13.-18.05.2018, Mariánské Lázně, Czeck Republic

Monocarboxylate transporter 1 (MCT1) is an integral plasma membrane protein that bi-directionally transports lactate and ketone bodies and is highly expressed in non-hypoxic regions of human colon, brain, breast, lung and other tumors. Accordingly, M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::fee3a0af18568fefb6d7c599e44da54d
https://www.hzdr.de/publications/Publ-27549-1

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