Výsledky vyhledávání - "Drew W. Sadowsky"

Choriodecidual Inflammation: A Harbinger of the Preterm Labor Syndrome

Autor: Drew W. Sadowsky, Kristina M. Adams Waldorf, Peta L. Grigsby, Miles J. Novy, Michael G. Gravett

Publikováno v: Reproductive Sciences. 17:85-94

Causal, cellular, and inflammatory links between choriodecidual infection with group B streptococcus (GBS) and preterm labor were assessed in a nonhuman primate model. Rhesus monkeys received varying doses of a clinical isolate of GBS, type III or sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fd010afc2afc1649130bae9e79d5b6
https://doi.org/10.1177/1933719109348025

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Ureaplasma parvum or Mycoplasma hominis as Sole Pathogens Cause Chorioamnionitis, Preterm Delivery, and Fetal Pneumonia in Rhesus Macaques

Autor: Gail H. Cassell, Drew W. Sadowsky, Ken B. Waites, Lynn B. Duffy, Steven S. Witkin, Michael G. Gravett, Miles J. Novy, Michael K. Axthelm

Publikováno v: Reproductive Sciences. 16:56-70

The authors assess causal, cellular and inflammatory links between intraamniotic infection with Ureaplasma parvum or Mycoplasma hominis and preterm labor in a nonhuman primate model. Long-term catheterized rhesus monkeys received intraamniotic inocul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0079bc376d5a1df6d1a51f78ee9a6f57
https://doi.org/10.1177/1933719108325508

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Relaxin and the Human Fetal Membranes

Autor: Andras Kern, Miles J. Novy, Drew W. Sadowsky, Gillian D. Bryant-Greenwood, Sandra Y. Yamamoto

Publikováno v: Reproductive Sciences. 14:42-45

The human fetal membranes are complex tissues that perform many important functions during gestation. The extracellular matrix provides their strength to withstand the forces directed from the fetus and myometrium. Relaxin is a collagenolytic hormone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c527edefd539d5a1c27e9507c2175ffd
https://doi.org/10.1177/1933719107310821

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Preterm labor is induced by intraamniotic infusions of interleukin-1β and tumor necrosis factor-α but not by interleukin-6 or interleukin-8 in a nonhuman primate model

Autor: Miles J. Novy, Michael G. Gravett, Steven S. Witkin, Drew W. Sadowsky, Kristina M. Adams

Publikováno v: American Journal of Obstetrics and Gynecology. 195:1578-1589

The purpose of this study was to determine the relative contributions of individual proinflammatory cytokines and chemokines to the triggering of preterm labor.Eighteen chronically instrumented pregnant rhesus monkeys at 135 +/- 3 days gestation (ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2692c55e3e59794fd5978ecf926d953a
https://doi.org/10.1016/j.ajog.2006.06.072

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Proteomic Analysis of Cervical−Vaginal Fluid: Identification of Novel Biomarkers for Detection of Intra-amniotic Infection

Autor: Archana Thomas, Michael G. Gravett, Srinivasa R. Nagalla, Surendra Dasari, Matthew Rodland, Charles T. Roberts, Thomas Jacob, Xinfang Lu, Miles J. Novy, Leonardo Pereira, Drew W. Sadowsky, Kimberly A. Schneider, Ashok P. Reddy

Publikováno v: Journal of Proteome Research. 6:89-96

Intra-amniotic infection (IAI) is associated with preterm birth and perinatal mortality. To identify potential biomarkers, we performed a comprehensive survey of the cervical-vaginal fluid (CVF) proteome from a primate IAI model utilizing multidimens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3575d951e1655d609266704b6941b41f
https://doi.org/10.1021/pr060149v

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Localization of prostaglandin H synthase, prostaglandin dehydrogenase, corticotropin releasing hormone and glucocorticoid receptor in rhesus monkey fetal membranes with labor and in the presence of infection

Autor: M.G. Gravett, G.J. Haluska, Miles J. Novy, Drew W. Sadowsky, John R. G. Challis, D. Giannoulias

Publikováno v: Placenta. 26:289-297

Prostaglandins (PGs) play a central role in primate parturition by their actions on uterine contractility and on cervical ripening. Rhesus monkey placentation is hemochorial and the endocrine events surrounding parturition are qualitatively similar t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0054624042a369fa3aa60e1c54b2a0
https://doi.org/10.1016/j.placenta.2004.07.005

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Progesterone receptor Localization and Isoforms in Myometrium, Decidua, and Fetal Membranes From Rhesus Macaques: Evidence for Function Progresterone Withdrawal at Parturtion

Autor: George J. Haluska, Jonathan J. Hirst, Drew W. Sadowsky, T. R. Wells, R. M. Brenner, Miles J. Novy

Publikováno v: Journal of the Society for Gynecologic Investigation. 9:125-136

It is not known whether withdrawal of progesterone (P) action is a prerequisite for parturition in women or in nonhuman primates because concentrations of circulating progesterone or progesterone receptors (PR) in myometrium and decidua do not decrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9217e3c7a6bcab718ccff8398efe9933
https://doi.org/10.1177/107155760200900303

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Indomethacin blocks interleukin 1β–induced myometrial contractions in pregnant rhesus monkeys

Autor: Miles J. Novy, George J. Haluska, Drew W. Sadowsky, Steven S. Witkin, Michael G. Gravett

Publikováno v: American Journal of Obstetrics and Gynecology. 183:173-180

We sought to determine whether blockade of prostaglandin synthesis with indomethacin prevents interleukin 1beta-induced increases in uterine contractions in a nonhuman primate model.Maternal and fetal vascular catheters, intra-amniotic fluid pressure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9396c69a9e1973a742ca48853b0588c
https://doi.org/10.1067/mob.2000.105968

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Amniotic Fluid Prolactin is Decreased by Experimental Intrauterine Infection or Interleukin-1 β Infusion but not via Prostaglandins in Pregnant Rhesus Macaques1

Autor: M. K. Axethelm, Miles J. Novy, Drew W. Sadowsky, George J. Haluska, Cynthia L. Bethea, Michael G. Gravett

Publikováno v: Biology of Reproduction. 58:1385-1393

Amniotic fluid contains a high concentration of prolactin produced and secreted by the decidua. In vitro models have suggested that bacterial products inhibit prolactin secretion by decidual cells. To further examine this potentially important regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::538982fcf07d00d8ccf35a65e98a6ff6
https://doi.org/10.1095/biolreprod58.6.1385

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Control of human parturition

Autor: Jane E. Mijovic, David M. Olson, Drew W. Sadowsky

Publikováno v: Seminars in Perinatology. 19:52-63

Parturition is a process that is composed of five separate and distinct physiological components but which lead from one to the next and are, therefore, interdependent. As such, the regulation of myometrial contractility should not be examined in iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712c72734efaf4a153acc2540e755958
https://doi.org/10.1016/s0146-0005(95)80047-6

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