Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Drew Sukovich"'
Autor:
John Morser, Imadul Islam, Cornell Mallari, Elena Ho, Marc Adler, Kumar Emayan, Gary Phillips, Shendong Yuan, Marc Whitlow, Christopher W. West, David R. Light, Giovanna Gualtieri, Drew Sukovich, Ulrich Bothe, Zheng Chang, Kieu Chu, Judi Bryant, Deborah Chen, Caralee Schaefer, Brad O. Buckman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3372-3375
We report here the design and synthesis of a novel series of benzylamines that are potent and selective inhibitors of uPA with promising oral availability in rat. Further evaluation of one representative (ZK824859) of the new structural class showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b761e7a2ae7d063c07c5d293801b02
https://doi.org/10.1016/j.bmcl.2018.09.001
https://doi.org/10.1016/j.bmcl.2018.09.001
Autor:
Gary Phillips, Rebecca Pulk, Christopher W. West, Danny Arnaiz, Shendong Yuan, Kieu Chu, Marc Adler, David R. Light, Deborah Chen, Elena Ho, Giovanna Gualtieri, Marc Whitlow, Christoph Huwe, Judi Bryant, Drew Sukovich
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
In this Letter we report the synthesis and evaluation of a series of non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Starting from compound 1, a significant change provided compounds in which the amidine, binding in the S1 pocket, wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60747fc1bc1095b1d652f959205693a8
https://pubmed.ncbi.nlm.nih.gov/19703768
https://pubmed.ncbi.nlm.nih.gov/19703768
Autor:
Imadul Islam, Paul Hrvatin, Kieu Chu, Marc Whitlow, Brad O. Buckman, Marc Adler, Drew Sukovich, John Morser, Christopher West, Shendong Yuan, Judi Bryant, Zheng Chang, Kumar Emayan
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 64(Pt 2)
This article reports the crystal structures of inhibitors of the functional form of thrombin-activatable fibrinolysis inhibitor (TAFIa). In vivo experiments indicate that selective inhibitors of TAFIa would be useful in the treatment of heart attacks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5377fbebefde91aec43492782d0f200a
https://pubmed.ncbi.nlm.nih.gov/18219114
https://pubmed.ncbi.nlm.nih.gov/18219114
Autor:
Ronald Vergona, John Morser, Jon Vincelette, Mariko Nagashima, Lei Zhao, Judi Bryant, Kumar Emayan, Wei-Wei Li, Shendong Yuan, Paul Hrvatin, Babu Subramanyam, Drew Sukovich, Imadul Islam, Brad O. Buckman, David R. Light, Yi-Xin Wang
Publikováno v:
Thrombosis and haemostasis. 97(1)
SummaryWe have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa), BX 528, which had an IC50 of 2 nM in an enzymatic assay and 50 nM in an in-vitro clot lysis ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb4909cf9deb49e412f2c270a27e4f5
https://pubmed.ncbi.nlm.nih.gov/17200770
https://pubmed.ncbi.nlm.nih.gov/17200770
Publikováno v:
Journal of Biological Chemistry. 269:11674
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0098bd1a7c08be9db8901fa70009bdde
https://doi.org/10.1016/s0021-9258(19)78181-2
https://doi.org/10.1016/s0021-9258(19)78181-2
Publikováno v:
Circulation Research; Oct1993, Vol. 73 Issue 4, p622-628, 7p
Heart Hypertrophy and Failure brings together leading basic scientists and clinicians, presenting improved knowledge of the pathophysiology and treatment of the condition. The result is a synthesis of state-of-the-art information on molecular biology
Vascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active mole