Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Drew Slauenwhite"'
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Beáta Dérfalvi, Thomas B. Issekutz
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood. The objective of this study was to examine the hypothesis that IFN expression profiles in th
Externí odkaz:
https://doaj.org/article/6604fe21c02a4a40848cb6c541f0e5ce
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Thomas B. Issekutz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveAntigen-presenting dendritic cells (DCs) and monocytes play an essential role in rheumatoid arthritis (RA) pathogenesis, however, their tolerogenic potential remains unclear. Herein, the tolerogenic profiles of DCs are characterized in treat
Externí odkaz:
https://doaj.org/article/ada887f28e424002807018d3e254353f
Autor:
Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu, Beata Derfalvi
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 18, Iss 1, Pp 1-11 (2022)
Abstract Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen
Externí odkaz:
https://doaj.org/article/03ad05a01adb459c9c83d1949a6d70a8
Autor:
Drew Slauenwhite, J G Hanly, Thomas B. Issekutz, Jean S. Marshall, Aniko Malik, Sarah M. McAlpine, Ian D. Haidl
Publikováno v:
Arthritis & Rheumatology. 72:1091-1102
OBJECTIVE Rheumatoid arthritis (RA) is a chronic inflammatory disease mediated through complex immunologic pathways. Among RA patients receiving low-dose methotrexate (MTX) monotherapy, approximately one-half exhibit a meaningful clinical response wi
Autor:
Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu, Beata Derfalvi
Publikováno v:
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 18(1)
Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen. PD is c
Publikováno v:
Arthritis & Rheumatology. 66:3001-3012
Objective The chemokine receptor CXCR6 is highly expressed on lymphocytes isolated from the synovium of patients with rheumatoid arthritis, psoriatic arthritis, or juvenile idiopathic arthritis, suggesting that CXCR6 regulates immune cell activation
Publikováno v:
European Journal of Immunology. 44:1633-1643
CCR4 and CXCR3 are expressed on several T-cell subsets in inflamed tissues, yet their role in tissue-specific recruitment is unclear. We examined the contributions of CCR4 and CXCR3 to T-cell recruitment into inflamed joints in collagen-induced arthr
Publikováno v:
Immunology and cell biology. 94(1)
Natural killer T (NKT) cells are glycolipid-reactive T lymphocytes that function in immunosurveillance and immune regulation. However, reduced tumor control in NKT cell-deficient Jα18(-/-) mice may be confounded by an overall reduction in T-cell rec
Publikováno v:
Oncoimmunology. 4(3)
Metastatic lesions are responsible for over 90% of breast cancer associated deaths. Therefore, strategies that target metastasis are of particular interest. This study examined the efficacy of natural killer T (NKT) cell activation as a post-surgical
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 66(11)
The chemokine receptor CXCR6 is highly expressed on lymphocytes isolated from the synovium of patients with rheumatoid arthritis, psoriatic arthritis, or juvenile idiopathic arthritis, suggesting that CXCR6 regulates immune cell activation or infiltr