Increased Protease-Activated Receptor-2 (PAR-2) Expression on CD14++CD16+ Peripheral Blood Monocytes of Patients with Severe Asthma.

Autor: Nami Shrestha Palikhe, Drew Nahirney, Cheryl Laratta, Vivek Dipak Gandhi, Dilini Vethanayagam, Mohit Bhutani, Irvin Mayers, Lisa Cameron, Harissios Vliagoftis

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144500 (2015)

Protease-Activated Receptor-2 (PAR-2), a G protein coupled receptor activated by serine proteases, is widely expressed in humans and is involved in inflammation. PAR-2 activation in the airways plays an important role in the development of allergic a

Externí odkaz: https://doaj.org/article/f2ca507f22314b829ce33b72bdee2f53

Stability of peripheral blood immune markers in patients with asthma

Autor: Harissios Vliagoftis, Vivek Dipak Gandhi, Mohit Bhutani, Irvin Mayers, Drew Nahirney, Lisa Cameron, Angela Hillaby, Cheryl R. Laratta, Ana-Maria Bosonea, Miranda Bowen, Nami Shrestha Palikhe

Publikováno v: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Allergy, Asthma & Clinical Immunology, Vol 15, Iss 1, Pp 1-10 (2019)

Background Asthma is a complex disease with variable course. Efforts to identify biomarkers to predict asthma severity, the course of disease and response to treatment have not been very successful so far. We have previous suggested that PAR-2 and CR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92f5f240a88e3302613697d6a42f84f
https://doi.org/10.1186/s13223-019-0343-4

The circular bacteriocin, carnocyclin A, forms anion-selective channels in lipid bilayers

Autor: Drew Nahirney, John C. Vederas, Marek Duszyk, Leah A. Martin-Visscher, Xiandi Gong

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788:1797-1803

Bacterial resistance to conventional antibiotics is a major challenge in controlling infectious diseases and has necessitated the development of novel approaches in antimicrobial therapy. One such approach is the use of antimicrobial peptides, such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3439916cdce4a5c871a47c7e16fd1f
https://doi.org/10.1016/j.bbamem.2009.05.008

Increased Protease-Activated Receptor-2 (PAR-2) Expression on CD14++CD16+ Peripheral Blood Monocytes of Patients with Severe Asthma

Autor: Irvin Mayers, Drew Nahirney, Nami Shrestha Palikhe, Dilini Vethanayagam, Harissios Vliagoftis, Vivek Dipak Gandhi, Cheryl R. Laratta, Mohit Bhutani, Lisa Cameron

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144500 (2015)

Background Protease-Activated Receptor-2 (PAR-2), a G protein coupled receptor activated by serine proteases, is widely expressed in humans and is involved in inflammation. PAR-2 activation in the airways plays an important role in the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6e56d6611b139346666e8a53c1f9eb
https://pubmed.ncbi.nlm.nih.gov/26658828

Growth factors regulate proteinase activated receptor – 2 (PAR-2) on airway epithelium

Autor: Harissios Vliagoftis, Vivek Dipak Gandhi, Drew Nahirney

Publikováno v: Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

Background Many aeroallergens activate PAR-2 receptors on the airway epithelium. We have shown that PAR-2 activation participates in allergic sensitization and allergic airway inflammation in animal models of asthma. Moreover, PAR-2 is upregulated on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50532ab241d97248fb748035eb84a34
https://doi.org/10.1186/1710-1492-10-s2-a11