Výsledky vyhledávání - "Drew D. Dudgeon"

New Regulators of a High Affinity Ca2+ Influx System Revealed through a Genome-wide Screen in Yeast

Autor: Veronica Beaudry, Carlos C. Evangelista, D. Christian Martin, Lymarie Maldonado-Báez, Kyle W. Cunningham, Daniel Q. Naiman, Drew D. Dudgeon, Scott E. Erdman, Nancy A. Mackin, Hyemin Kim

Publikováno v: Journal of Biological Chemistry. 286:10744-10754

The bakers' yeast Saccharomyces cerevisiae utilizes a high affinity Ca(2+) influx system (HACS) to survive assaults by mating pheromones, tunicamycin, and azole-class antifungal agents. HACS consists of two known subunits, Cch1 and Mid1, that are hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9797dc06eebdd71baf2cfef93b8d964d
https://doi.org/10.1074/jbc.m110.177451

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Characterization and Optimization of a Novel Protein–Protein Interaction Biosensor High-Content Screening Assay to Identify Disruptors of the Interactions Between p53 and hDM2

Autor: Drew D. Dudgeon, Paul A. Johnston, Patricia A. Johnston, John S. Lazo, Christopher J. Strock, Kenneth A. Giuliano, Sunita Shinde, Tong Ying Shun, D. Lansing Taylor

Publikováno v: ASSAY and Drug Development Technologies. 8:437-458

We present here the characterization and optimization of a novel imaging-based positional biosensor high-content screening (HCS) assay to identify disruptors of p53-hDM2 protein–protein interactions (PPIs). The chimeric proteins of the biosensor in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c150a85a03f6bb6cb3d1461899f25e4
https://doi.org/10.1089/adt.2010.0281

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Nonapoptotic Death of Saccharomyces cerevisiae Cells That Is Stimulated by Hsp90 and Inhibited by Calcineurin and Cmk2 in Response to Endoplasmic Reticulum Stresses

Autor: Nannan Zhang, Olufisayo O. Ositelu, Drew D. Dudgeon, Hyemin Kim, Kyle W. Cunningham

Publikováno v: Eukaryotic Cell. 7:2037-2051

Endoplasmic reticulum (ER) stress can trigger apoptosis and necrosis in many types of mammalian cells. Previous studies in yeast found little or no cell death in response to the ER stressor tunicamycin, but a recent study suggested widespread apoptos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15726f0f21c3fa62d5ebfa0eadba81c
https://doi.org/10.1128/ec.00291-08

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Multiple Signaling Pathways Regulate Yeast Cell Death during the Response to Mating Pheromones

Autor: Saurabh Paliwal, Nannan Zhang, Drew D. Dudgeon, Andre Levchenko, Eric Grote, Kyle W. Cunningham

Publikováno v: Molecular Biology of the Cell. 17:3409-3422

Mating pheromones promote cellular differentiation and fusion of yeast cells with those of the opposite mating type. In the absence of a suitable partner, high concentrations of mating pheromones induced rapid cell death in ∼25% of the population o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7978b820ee84dd2fa46b44fb098b225
https://doi.org/10.1091/mbc.e06-03-0177

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Optimization of ultrasound contrast agents with computational models to improve selection of ligands and binding strength

Autor: John S. Lazo, Drew D. Dudgeon, Daniel A. Hammer, Michael T. Beste, Timothy M. Maul, Flordeliza S. Villanueva, William R. Wagner

Publikováno v: Biotechnology and bioengineering. 107(5)

Diagnosis of cardiovascular disease is currently limited by the testing modality. Serum tests for biomarkers can provide quantification of severity but lack the ability to localize the source of the cardiovascular disease, while imaging technology su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c0e6420386f07d2501516855f299d3
https://pubmed.ncbi.nlm.nih.gov/20665479

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Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits

Autor: Tong Ying Shun, John S. Lazo, Kenneth A. Giuliano, Paul A. Johnston, Christopher J. Strock, D. Lansing Taylor, Drew D. Dudgeon, Patricia A. Johnston, Sunita Shinde, Yun Hua

Publikováno v: Journal of biomolecular screening. 15(7)

In recent years, advances in structure-based drug design and the development of an impressive variety of high-throughput screening (HTS) assay formats have yielded an expanding list of protein-protein interaction inhibitors. Despite these advances, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982a5c1ccf133fedfeedb846017f5de2
https://pubmed.ncbi.nlm.nih.gov/20639499

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The Substrate Recognition Domains of the N-end Rule Pathway*

Autor: Adriana Zakrzewska, John S. Lazo, Takafumi Tasaki, Drew D. Dudgeon, Yong Tae Kwon, Yonghua Jiang

The N-end rule pathway is a ubiquitin-dependent system where E3 ligases called N-recognins, including UBR1 and UBR2, recognize type-1 (basic) and type-2 (bulky hydrophobic) N-terminal residues as part of N-degrons. We have recently reported an E3 fam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b835e9714be87c938cc12ad3125ffc
https://europepmc.org/articles/PMC2615520/

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