Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease.

Autor: Quinn L; Dept of Biobehavioral Sciences, Teachers College, Columbia University, NY, NY, USA; Centre for Trials Research, Cardiff University, UK., Playle R; Centre for Trials Research, Cardiff University, UK., Drew CJG; Centre for Trials Research, Cardiff University, UK., Taiyari K; Centre for Trials Research, Cardiff University, UK., Williams-Thomas R; Centre for Trials Research, Cardiff University, UK., Muratori LM; George-Huntington-Institute and Institute for Clinical Radiology, University of Münster, Münster, Germany; Stony Brook University, Stony Brook, NY, USA., Hamana K; School of Healthcare Sciences, Cardiff University, UK., Griffin BA; RAND Corporation, Arlington, VA, USA., Kelson M; Department of Mathematics, Exeter University, Exeter, UK., Schubert R; George-Huntington-Institute and Institute for Clinical Radiology, University of Münster, Münster, Germany., Friel C; Feinstein Institutes for Medical Research, Northwell Health, NY, NY, UK., Morgan-Jones P; Centre for Trials Research, Cardiff University, UK; School of Engineering, Cardiff University, Cardiff, UK., Rosser A; Schools of Medicine and Biosciences, Cardiff University, Cardiff, UK., Busse M; Centre for Trials Research, Cardiff University, UK. Electronic address: busseme@cardiff.ac.

Publikováno v: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2022 Aug; Vol. 101, pp. 75-89. Date of Electronic Publication: 2022 Jun 29.

Considerations for clinical trial design and conduct in the evaluation of novel advanced therapeutics in neurodegenerative disease.

Autor: Drew CJG; Centre For Trials Research, Cardiff University, Cardiff, United Kingdom; Brain Repair and Intracranial Neurotherapeutics Unit (BRAIN), College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom. Electronic address: drewc5@cardiff.ac.uk., Busse M; Centre For Trials Research, Cardiff University, Cardiff, United Kingdom; Brain Repair and Intracranial Neurotherapeutics Unit (BRAIN), College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom.

Publikováno v: International review of neurobiology [Int Rev Neurobiol] 2022; Vol. 166, pp. 235-279. Date of Electronic Publication: 2022 Oct 22.

A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD).

Autor: Yhnell E; Neuroscience and Mental Health Research Institute, Cardiff University (NMHRI), 3rd Floor, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ UK.; Cardiff University School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX UK., Furby H; School of Psychology, Cardiff University Brain Research Imaging Centre (CUBRIC), Maindy Road, Cardiff University, Cardiff, CF24 4HQ UK., Lowe RS; Centre for Trials Research (CTR), Cardiff University, Neuadd Meironnydd, Heath Park, Cardiff, CF14 4YS UK., Brookes-Howell LC; Centre for Trials Research (CTR), Cardiff University, Neuadd Meironnydd, Heath Park, Cardiff, CF14 4YS UK., Drew CJG; Centre for Trials Research (CTR), Cardiff University, Neuadd Meironnydd, Heath Park, Cardiff, CF14 4YS UK., Playle R; Centre for Trials Research (CTR), Cardiff University, Neuadd Meironnydd, Heath Park, Cardiff, CF14 4YS UK., Watson G; Centre for Trials Research (CTR), Cardiff University, Neuadd Meironnydd, Heath Park, Cardiff, CF14 4YS UK., Metzler-Baddeley C; School of Psychology, Cardiff University Brain Research Imaging Centre (CUBRIC), Maindy Road, Cardiff University, Cardiff, CF24 4HQ UK., Rosser AE; Neuroscience and Mental Health Research Institute, Cardiff University (NMHRI), 3rd Floor, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ UK.; Cardiff University Brain Repair Group, Life Sciences Building, Museum Avenue, Cardiff, CF10 3AX UK., Busse ME; Centre for Trials Research (CTR), Cardiff University, Neuadd Meironnydd, Heath Park, Cardiff, CF14 4YS UK.

Publikováno v: Pilot and feasibility studies [Pilot Feasibility Stud] 2020 Jun 19; Vol. 6, pp. 88. Date of Electronic Publication: 2020 Jun 19 (Print Publication: 2020).

A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial).

Autor: Drew CJG; 1Centre for Trials Research, Cardiff University, Heath Park, Cardiff, CF14 4YS UK., Postans M; 2Cardiff University Brain Research Imaging Centre (CUBRIC), Maindy Road, Cardiff, CF24 4HQ UK.; 3School of Psychology, Cardiff University, Tower Building, 70 Park Place, Cardiff, CF10 3AT UK., Petralia C; 4Division of Psychological Medicine and Clinical Neurosciences, University Hospital Wales, Cardiff and Vale University Health Board, Heath Park, Cardiff, CF14 4XW UK., McNamara R; 1Centre for Trials Research, Cardiff University, Heath Park, Cardiff, CF14 4YS UK., Pallmann P; 1Centre for Trials Research, Cardiff University, Heath Park, Cardiff, CF14 4YS UK., Gillespie D; 1Centre for Trials Research, Cardiff University, Heath Park, Cardiff, CF14 4YS UK., Evans LH; 2Cardiff University Brain Research Imaging Centre (CUBRIC), Maindy Road, Cardiff, CF24 4HQ UK.; 3School of Psychology, Cardiff University, Tower Building, 70 Park Place, Cardiff, CF10 3AT UK., Muhlert N; 3School of Psychology, Cardiff University, Tower Building, 70 Park Place, Cardiff, CF10 3AT UK.; 5Division of Neuroscience and Experimental Psychology, Manchester University, Manchester, UK., Winter M; 3School of Psychology, Cardiff University, Tower Building, 70 Park Place, Cardiff, CF10 3AT UK.; 6Department of Clinical Neuropsychology, University Hospital Wales, Cardiff, CF14 4XW UK., Hamandi K; 2Cardiff University Brain Research Imaging Centre (CUBRIC), Maindy Road, Cardiff, CF24 4HQ UK.; 7The Alan Richens Welsh Epilepsy Centre, University Hospital Wales, Cardiff, CF144XW UK., Gray WP; 4Division of Psychological Medicine and Clinical Neurosciences, University Hospital Wales, Cardiff and Vale University Health Board, Heath Park, Cardiff, CF14 4XW UK.; Neuroscience and Mental Health Research Institute, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ UK.

Publikováno v: Pilot and feasibility studies [Pilot Feasibility Stud] 2019 Jul 06; Vol. 5, pp. 87. Date of Electronic Publication: 2019 Jul 06 (Print Publication: 2019).

New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.

Autor: Bode A; University of Queensland, Queensland Brain Institute and School of Biomedical Sciences, Queensland 4072, Australia., Wood SE; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Mullins JGL; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Keramidas A; University of Queensland, Queensland Brain Institute and School of Biomedical Sciences, Queensland 4072, Australia., Cushion TD; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Thomas RH; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom; Wales Epilepsy Research Network, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Pickrell WO; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom; Wales Epilepsy Research Network, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Drew CJG; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom; Wales Epilepsy Research Network, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Masri A; Department of Paediatrics, Division of Child Neurology, Faculty of Medicine, University of Jordan, Amman 11942, Jordan., Jones EA; Manchester Centre for Genomic Medicine, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9WL, United Kingdom; Manchester Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9WL, United Kingdom., Vassallo G; Royal Manchester Children's Hospital, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9WL, United Kingdom., Born AP; Department of Pediatrics, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark., Alehan F; Department of Pediatrics, Division of Child Neurology, Faculty of Medicine, Basşkent University, 06990 Ankara, Turkey., Aharoni S; Institute of Pediatric Neurology, Schneider Children's Medical Center of Israel, Petah Tikva 49202, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69987, Israel., Bannasch G; Neurology Department, Affinity Medical Group, Menasha, Wisconsin 54952., Bartsch M; Department of Neonatology, University Medical Center of the Johannes Gutenberg University Mainz, D-55099 Mainz, Germany., Kara B; Kocaeli University Medical Faculty, Department of Pediatrics, Division of Child Neurology, 41380 Kocaeli, Turkey., Krause A; Division of Human Genetics, National Health Laboratory Service, and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2000 Johannesburg, South Africa., Karam EG; Department of Psychiatry and Clinical Psychology, Saint George Hospital University Medical Center, Balamand University, Faculty of Medicine, Beirut 1100 2807, Lebanon., Matta S; Department of Psychiatry and Clinical Psychology, Saint George Hospital University Medical Center, Balamand University, Faculty of Medicine, Beirut 1100 2807, Lebanon., Jain V; Royal Children's Hospital Melbourne, Children's Neuroscience Centre, Royal Children's Hospital, Victoria 3052, Australia., Mandel H; Metabolic Unit, Meyer Children's Hospital, Rambam Medical Center, Technion Faculty of Medicine, Haifa 31096, Israel., Freilinger M; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria., Graham GE; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario K1H 8L1, Canada., Hobson E; Yorkshire Regional Genetic Service, Chapel Allerton Hospital, Leeds, West Yorkshire LS9 7TF, United Kingdom., Chatfield S; Neonatal Unit, Bradford Royal Infirmary, Bradford, West Yorkshire BD9 6RJ, United Kingdom., Vincent-Delorme C; Génétique, Pôle Mère, Enfant, Centre Hospitalier d'Arras, 62 000 Arras, France., Rahme JE; Clalit Health Services, Shfaram 20200, Israel., Afawi Z; Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel., Berkovic SF; Epilepsy Research Centre, Melbourne Brain Centre, Austin Health, Heidelberg 3084, Victoria, Australia., Howell OW; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom; Wales Epilepsy Research Network, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Vanbellinghen JF; Institut de Pathologie et de Génétique ASBL/IRSPG, B-6041 Gosselies, Belgium., Rees MI; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom; Wales Epilepsy Research Network, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Chung SK; Department of Neurology Research and Molecular Neuroscience, Institute of Life Science, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom; Wales Epilepsy Research Network, College of Medicine, Swansea University Swansea SA2 8PP, United Kingdom., Lynch JW; University of Queensland, Queensland Brain Institute and School of Biomedical Sciences, Queensland 4072, Australia. Electronic address: j.lynch@uq.edu.au.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Nov 22; Vol. 288 (47), pp. 33745-33759. Date of Electronic Publication: 2013 Oct 09.