Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Drew, Weissman"'
Autor:
Rebecca A. Leonard, Kaitlyn N. Burke, Rachel L. Spreng, Andrew N. Macintyre, Ying Tam, Mohamad-Gabriel Alameh, Drew Weissman, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Influenza viruses cause substantial morbidity and mortality every year despite seasonal vaccination. mRNA-based vaccines have the potential to elicit more protective immune responses, but for maximal breadth and durability, it is desirable t
Externí odkaz:
https://doaj.org/article/f45c2481b42140e7a45c7cc1e869732c
Autor:
Elena N. Atochina-Vasserman, Lisa C. Lindesmith, Carmen Mirabelli, Nathan A. Ona, Erin K. Reagan, Paul D. Brewer-Jensen, Xiomara Mercado-Lopez, Hamna Shahnawaz, Jaclynn A. Meshanni, Ishana Baboo, Michael L. Mallory, Mark R. Zweigart, Samantha R. May, Barbara L. Mui, Ying K. Tam, Christiane E. Wobus, Ralph S. Baric, Drew Weissman
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Nucleoside-modified mRNA-LNP vaccines have revolutionized vaccine development against infectious pathogens due to their ability to elicit potent humoral and cellular immune responses. In this article, we present the results of the first noro
Externí odkaz:
https://doaj.org/article/edc4158664a44a999625dbd69f0184a0
Autor:
Renee L. Hajnik, Jessica A. Plante, Srinivasa Reddy Bonam, Grace H. Rafael, Yuejin Liang, Nicholas C. Hazell, Jordyn Walker, Rachel A. Reyna, David H. Walker, Mohamad-Gabriel Alameh, Drew Weissman, Scott C. Weaver, Kenneth S. Plante, Haitao Hu
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract While first-generation, spike (S)-based COVID-19 vaccines were effective against early SARS-CoV-2 strains, the rapid evolution of novel Omicron subvariants have substantially reduced vaccine efficacy. As such, broadly protective vaccines aga
Externí odkaz:
https://doaj.org/article/e156f7e99f7a4151bd2453735a5ab1ac
Evaluation of mRNA-LNP and adjuvanted protein SARS-CoV-2 vaccines in a maternal antibody mouse model
Autor:
Ross N. England, Elizabeth M. Drapeau, Mohamad-Gabriel Alameh, Reihaneh Hosseinzadeh, Drew Weissman, Scott E. Hensley
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-8 (2024)
Abstract Maternal antibodies (matAbs) protect against a myriad of pathogens early in life; however, these antibodies can also inhibit de novo immune responses against some vaccine platforms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
Externí odkaz:
https://doaj.org/article/ce31953d47bc4fc28564989d3cbd2e47
Autor:
Anna R. Smith, Fatima Rizvi, Elissa Everton, Anisah Adeagbo, Susan Wu, Ying Tam, Hiromi Muramatsu, Norbert Pardi, Drew Weissman, Valerie Gouon-Evans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Primary human hepatocyte (PHH) transplantation is a promising alternative to liver transplantation, whereby liver function could be restored by partial repopulation of the diseased organ with healthy cells. However, currently PHH engraftment
Externí odkaz:
https://doaj.org/article/647d49ee412444f89823e041d316739f
Autor:
Colleen Furey, Gabrielle Scher, Naiqing Ye, Lisa Kercher, Jennifer DeBeauchamp, Jeri Carol Crumpton, Trushar Jeevan, Christopher Patton, John Franks, Adam Rubrum, Mohamad-Gabriel Alameh, Steven H. Y. Fan, Anthony T. Phan, Christopher A. Hunter, Richard J. Webby, Drew Weissman, Scott E. Hensley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract mRNA lipid nanoparticle (LNP) vaccines would be useful during an influenza virus pandemic since they can be produced rapidly and do not require the generation of egg-adapted vaccine seed stocks. Highly pathogenic avian influenza viruses from
Externí odkaz:
https://doaj.org/article/5d9fb3b6c921403890d39dcf66be7f99
Autor:
Rachel E. Young, Katherine M. Nelson, Samuel I. Hofbauer, Tara Vijayakumar, Mohamad-Gabriel Alameh, Drew Weissman, Charalampos Papachristou, Jason P. Gleghorn, Rachel S. Riley
Publikováno v:
Bioactive Materials, Vol 34, Iss , Pp 125-137 (2024)
Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA stability, circulation time, cellular uptake, and preferential delivery to
Externí odkaz:
https://doaj.org/article/030cc556d30340f79b8eba32bbbbe63c
Autor:
Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This c
Externí odkaz:
https://doaj.org/article/37d2ab50b881474f81175ff5bf88cc4e
Autor:
Hamideh Parhiz, Vladimir V. Shuvaev, Qin Li, Tyler E. Papp, Awurama A. Akyianu, Ruiqi Shi, Amir Yadegari, Hamna Shahnawaz, Sean C. Semple, Barbara L. Mui, Drew Weissman, Vladimir R. Muzykantov, Patrick M. Glassman
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102175- (2024)
RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is the lack of clear pharmacokinetic (PK)-pharmacodynamic relationship, in part due to the si
Externí odkaz:
https://doaj.org/article/7f789f117b494a00a874576d1146347e
Autor:
Hsuan-Yuan Wang, Leike Li, Cody S. Nelson, Richard Barfield, Sarah Valencia, Cliburn Chan, Hiromi Muramatsu, Paulo J. C. Lin, Norbert Pardi, Zhiqiang An, Drew Weissman, Sallie R. Permar
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Human cytomegalovirus (HCMV) remains the most common congenital infection and infectious complication in immunocompromised patients. The most successful HCMV vaccine to date, an HCMV glycoprotein B (gB) subunit vaccine adjuvanted with MF59,
Externí odkaz:
https://doaj.org/article/585f42ecc487449fb50c16c8c227987f