Development of iterative optimization technology: Selecting pure component spectra using a small-scale feed frame simulator.

Autor: Henson S; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA., Rish AJ; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA., Anik Alam M; Worldwide Research and Development, Pfizer Inc., Groton, CT 06340, USA., Liu Y; Worldwide Research and Development, Pfizer Inc., Groton, CT 06340, USA., Drennen JK; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, USA., Anderson CA; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, USA. Electronic address: andersonca@duq.edu.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2024 May 25; Vol. 657, pp. 124079. Date of Electronic Publication: 2024 Apr 03.

NIR Spectroscopy as an Online PAT Tool for a Narrow Therapeutic Index Drug: Toward a Platform Approach Across Lab and Pilot Scales for Development of a Powder Blending Monitoring Method and Endpoint Determination.

Autor: Talwar S; Duquesne University Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA, 15282, USA.; MST-BPDS-Biopharm Product Dev & Supply, GSK, 709 Swedeland Road, King of Prussia, PA, 19406, USA., Pawar P; Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ, 08854, USA.; Gilead, Foster City, CA, 94404, USA., Wu H; Office of Pharmaceutical Quality, CDER, FDA, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. Huiquan.wu@fda.hhs.gov., Sowrirajan K; Office of Pharmaceutical Quality, CDER, FDA, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA., Wu S; Office of Pharmaceutical Quality, CDER, FDA, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA., Igne B; Duquesne University Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA, 15282, USA., Friedman R; Office of Manufacturing Quality, Office of Compliance, CDER, FDA, Silver Spring, MD, 20993, USA., Muzzio FJ; Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ, 08854, USA., Drennen JK 3rd; Duquesne University Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA, 15282, USA. Drennen@duq.edu.

Publikováno v: The AAPS journal [AAPS J] 2022 Sep 28; Vol. 24 (6), pp. 103. Date of Electronic Publication: 2022 Sep 28.

Application of a wavelength angle mapper for variable selection in iterative optimization technology predictions of drug content in pharmaceutical powder mixtures.

Autor: Rish AJ; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA., Henson SR; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA., Velez-Silva NL; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA., Nahid Hasan M; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA., Drennen JK; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, USA., Anderson CA; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, USA; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, USA. Electronic address: andersonca@duq.edu.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2023 Aug 25; Vol. 643, pp. 123261. Date of Electronic Publication: 2023 Jul 20.

Capacitance spectroscopy enables real-time monitoring of early cell death in mammalian cell culture.

Autor: Wu S; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania, USA.; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, Pennsylvania, USA., Ketcham SA; Manufacturing Science and Technology, Bristol-Myers Squibb, Devens, Massachusetts, USA., Corredor CC; Pharmaceutical Development, Bristol-Myers Squibb, New Brunswick, New Jersey, USA., Both D; Pharmaceutical Development, Bristol-Myers Squibb, New Brunswick, New Jersey, USA., Drennen JK; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania, USA.; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, Pennsylvania, USA., Anderson CA; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania, USA.; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, Pennsylvania, USA.

Publikováno v: Biotechnology journal [Biotechnol J] 2023 Mar; Vol. 18 (3), pp. e2200231. Date of Electronic Publication: 2022 Dec 22.

Challenges, opportunities and recent advances in near infrared spectroscopy applications for monitoring blend uniformity in the continuous manufacturing of solid oral dosage forms.

Autor: Velez NL; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, United States; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: velezn@duq.edu., Drennen JK; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, United States; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: drennen@duq.edu., Anderson CA; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, United States; Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: andersonca@duq.edu.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2022 Mar 05; Vol. 615, pp. 121462. Date of Electronic Publication: 2022 Jan 10.