Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence.

Autor: Razvi E; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Whitfield GB; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Département de Microbiologie, Infectiologie, et Immunologie, Faculté de Médecine Université de Montréal, Montréal, QC, Canada., Reichhardt C; Department of Microbiology, University of Washington, Seattle, WA, USA.; Department of Chemistry, Washington University, St. Louis, MO, USA., Dreifus JE; Department of Microbiology, University of Washington, Seattle, WA, USA., Willis AR; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Gluscencova OB; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada., Gloag ES; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.; Department of Biomedical Sciences and Pathobiology, VA-MD College of Veterinary Medicine, Virginia Tech, VA, 24061, USA., Awad TS; Department of Materials Science and Engineering, University of Toronto, Toronto, ON, Canada., Rich JD; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., da Silva DP; Department of Microbiology, University of Washington, Seattle, WA, USA.; BioVectra Inc. 11 Aviation, Charlottetown, PE, Canada., Bond W; Department of Microbiology, University of Washington, Seattle, WA, USA., Le Mauff F; Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Infectious Disease and Immunity in Global Health, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, QC, Canada., Sheppard DC; Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Infectious Disease and Immunity in Global Health, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, QC, Canada., Hatton BD; Department of Materials Science and Engineering, University of Toronto, Toronto, ON, Canada., Stoodley P; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.; Department of Orthopedics, The Ohio State University, Columbus, OH, 43210, USA.; National Biofilm Innovation Centre (NBIC) and National Centre for Advanced Tribology at Southampton (nCATS), University of Southampton, Southampton, SO17 1BJ, UK.; Department of Microbiology, The Ohio State University, Columbus, OH, 43210, USA., Reinke AW; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Boulianne GL; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada., Wozniak DJ; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.; Department of Microbiology, The Ohio State University, Columbus, OH, 43210, USA., Harrison JJ; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Parsek MR; Department of Microbiology, University of Washington, Seattle, WA, USA., Howell PL; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON, Canada. howell@sickkids.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. howell@sickkids.ca.

Publikováno v: NPJ biofilms and microbiomes [NPJ Biofilms Microbiomes] 2023 Feb 02; Vol. 9 (1), pp. 7. Date of Electronic Publication: 2023 Feb 02.

The Wsp system of Pseudomonas aeruginosa links surface sensing and cell envelope stress.

Autor: O'Neal L; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109., Baraquet C; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109.; Laboratoire Matériaux, Polymères, Interfaces et Environnement Marin, Université de Toulon, 83041 Toulon, France., Suo Z; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109.; Guangdong Province Sociomicrobiology Basic Science and Frontier Technology Research Team & Integrative Microbiology Research Center, South China Agricultural University, 510642 Guangzhou, China., Dreifus JE; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109., Peng Y; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Raivio TL; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Wozniak DJ; Department of Microbiology, The Ohio State University, Columbus, OH 43210., Harwood CS; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109., Parsek MR; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 03; Vol. 119 (18), pp. e2117633119. Date of Electronic Publication: 2022 Apr 27.

Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis.

Autor: Lang KS; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195., Hall AN; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195; Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195., Merrikh CN; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195., Ragheb M; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195; Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195., Tabakh H; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195., Pollock AJ; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195., Woodward JJ; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195., Dreifus JE; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195., Merrikh H; Department of Microbiology, Health Sciences Building - J-wing, University of Washington, Seattle, WA, 98195; Department of Genome Sciences, Foege Building, University of Washington, Seattle, WA 98195. Electronic address: merrikh@uw.edu.

Publikováno v: Cell [Cell] 2017 Aug 10; Vol. 170 (4), pp. 787-799.e18.