Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer.

Autor: Huth T; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Dreher EC; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Lemke S; Quantitative Biology Center (QBiC), University of Tübingen, 72076 Tübingen, Germany.; Department of Peptide-based Immunotherapy, University and University Hospital Tübingen, 72076 Tübingen, Germany.; Institute for Cell Biology, Department of Immunology, University of Tübingen, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany., Fritzsche S; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Sugiyanto RN; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Castven D; Department of Medicine I, University Medical Center Schleswig Holstein, 23538 Lübeck, Germany., Ibberson D; Deep Sequencing Core Facility, CellNetworks Excellence Cluster, Heidelberg University, 69120 Heidelberg, Germany., Sticht C; NGS Core Facility, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Eiteneuer E; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Jauch A; Institute of Human Genetics, Heidelberg University, 69120 Heidelberg, Germany., Pusch S; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Albrecht T; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Goeppert B; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Institute of Tissue Medicine and Pathology, University of Bern, 3008 Bern, Switzerland.; Institute of Pathology and Neuropathology, RKH Klinikum Ludwigsburg, 71640 Ludwigsburg, Germany., Candia J; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Wang XW; Laboratory of Human Carcinogenesis and Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Ji J; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China., Marquardt JU; Department of Medicine I, University Medical Center Schleswig Holstein, 23538 Lübeck, Germany., Nahnsen S; Quantitative Biology Center (QBiC), University of Tübingen, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, 72076 Tübingen, Germany.; Biomedical Data Science, Department of Computer Science, University of Tübingen, 72076 Tübingen, Germany.; The M3 Research Center, University of Tübingen, 72076 Tübingen, Germany., Schirmacher P; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Roessler S; Heidelberg University, Medical Faculty, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Publikováno v: Science advances [Sci Adv] 2023 Dec 22; Vol. 9 (51), pp. eadh1442. Date of Electronic Publication: 2023 Dec 22.