PG545 sensitizes ovarian cancer cells to PARP inhibitors through modulation of RAD51-DEK interaction.

Autor: Ray U; Department of Experimental Pathology and Medicine, Mayo Clinic, Rochester, MN, USA., Thirusangu P; Department of Experimental Pathology and Medicine, Mayo Clinic, Rochester, MN, USA., Jin L; Department of Experimental Pathology and Medicine, Mayo Clinic, Rochester, MN, USA., Xiao Y; Department of Experimental Pathology and Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China., Pathoulas CL; University of Connecticut Health Center-Medical School, Farmington, CT, USA., Staub J; Department of Experimental Pathology and Medicine, Mayo Clinic, Rochester, MN, USA., Erskine CL; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Dredge K; Zucero Therapeutics, South Melbourne, VIC, Australia., Hammond E; Zucero Therapeutics, South Melbourne, VIC, Australia., Block MS; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Kaufmann SH; Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Bakkum-Gamez JN; Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA., Shridhar V; Department of Experimental Pathology and Medicine, Mayo Clinic, Rochester, MN, USA. shridhar.vijayalakshmi@mayo.edu.

Publikováno v: Oncogene [Oncogene] 2023 Sep; Vol. 42 (37), pp. 2725-2736. Date of Electronic Publication: 2023 Aug 07.

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models.

Autor: Dredge, K.¹ keithd@progen-pharma.com, Hammond, E.¹, Handley, P.¹, Gonda, T. J.², Smith, M. T.³, Vincent, C.⁴, Brandt, R.⁴, Ferro, V.^1,5, Bytheway, I.¹

Publikováno v: British Journal of Cancer. 2/15/2011, Vol. 104 Issue 4, p635-642. 8p. 1 Diagram, 2 Charts, 5 Graphs.

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.

Autor: Guimond SE; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Mycroft-West CJ; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Gandhi NS; School of Chemistry and Physics, Centre for Genomics and Personalized Health, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4000, Australia., Tree JA; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Le TT; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia., Spalluto CM; School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton SO17 1BJ, United Kingdom., Humbert MV; School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton SO17 1BJ, United Kingdom., Buttigieg KR; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Coombes N; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Elmore MJ; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Wand M; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Nyström K; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Said J; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Setoh YX; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Amarilla AA; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Sng JDJ; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Chhabra M; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Young PR; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Rawle DJ; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia., Lima MA; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Yates EA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom., Karlsson R; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Miller RL; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Chen YH; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Bagdonaite I; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Yang Z; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Stewart J; Department of Infection Biology & Microbiomes, University of Liverpool, Liverpool L69 7ZB, United Kingdom., Nguyen D; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom., Laidlaw S; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom., Hammond E; Zucero Therapeutics Ltd, 1 Westlink Court, Brisbane, Queensland 4076, Australia., Dredge K; Zucero Therapeutics Ltd, 1 Westlink Court, Brisbane, Queensland 4076, Australia., Wilkinson TMA; School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton SO17 1BJ, United Kingdom.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, United Kingdom., Watterson D; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Khromykh AA; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Suhrbier A; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia., Carroll MW; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom., Trybala E; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Bergström T; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Ferro V; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Skidmore MA; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Turnbull JE; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom.; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom.; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark.

Publikováno v: ACS central science [ACS Cent Sci] 2022 May 25; Vol. 8 (5), pp. 527-545. Date of Electronic Publication: 2022 Mar 29.

A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis.

Autor: Buitrago G; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia; Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Pickering D; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Ruscher R; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Cobos Caceres C; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Jones L; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Cooper M; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia; Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Van Waardenberg A; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia; Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Ryan S; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Miles K; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Field M; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia; Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Dredge K; Zucero Therapeutics Ltd, Brisbane, Queensland, Australia., Daly NL; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Giacomin PR; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia. Electronic address: Paul.Giacomin@jcu.edu.au., Loukas A; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia. Electronic address: Alex.Loukas@jcu.edu.au.

Publikováno v: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2021 Jun; Vol. 232, pp. 88-102. Date of Electronic Publication: 2021 Mar 04.

Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease.

Autor: Yang, Jian-Ping¹ (AUTHOR), Toughiri, Rachel¹ (AUTHOR), Gounder, Anshu P.¹ (AUTHOR), Scheibe, Dan¹ (AUTHOR), Petrus, Matt¹ (AUTHOR), Fink, Sarah J.² (AUTHOR), Vallee, Sebastien² (AUTHOR), Kenniston, Jon² (AUTHOR), Papaioannou, Nikolaos² (AUTHOR), Langston, Steve² (AUTHOR), Gavva, Narender R.¹ (AUTHOR), Horman, Shane R.¹ (AUTHOR) shanehorman@gmail.com

Publikováno v: PLoS ONE. 11/6/2024, Vol. 19 Issue 11, p1-16. 16p.