Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Drazen Raucher"'
Publikováno v:
Molecules, Vol 29, Iss 4, p 840 (2024)
Glioblastoma multiforme (GBM), a grade IV (WHO classification) malignant brain tumor, poses significant challenges in treatment. The current standard treatment involves surgical tumor removal followed by radiation and chemotherapeutic interventions.
Externí odkaz:
https://doaj.org/article/e7d3dc7f541f470ba66ee0654e4bdccd
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 718 (2023)
Glioblastoma is a highly aggressive disease with poor patient outcomes despite current treatment options, which consist of surgery, radiation, and chemotherapy. However, these strategies present challenges such as resistance development, damage to he
Externí odkaz:
https://doaj.org/article/89e2729132e24ad7ac83cd61122aeaa0
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2072 (2022)
Glioblastoma (GBM) is a primary brain tumor that carries a dismal prognosis, which is primarily attributed to tumor recurrence after surgery and resistance to chemotherapy. Since the tumor recurrence appears near the site of surgical resection, a con
Externí odkaz:
https://doaj.org/article/3a39ded0e94b4ff8a7313461225c56b4
Publikováno v:
Molecules, Vol 27, Iss 11, p 3371 (2022)
The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin’s efficiency in killing tumor cells, severe damage to healthy tissues, along with cardiotox
Externí odkaz:
https://doaj.org/article/6b738d11590248ce99e0290b2a90dd45
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2301 (2022)
Although doxorubicin (dox), an anthracycline antibiotic, is widely used and effective in treating cancer, its treatment efficiency is limited by low blood plasma solubility, poor pharmacokinetics, and adverse side effects, including irreversible card
Externí odkaz:
https://doaj.org/article/24c19547f5144c4987868b0d69ac4d88
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Glioblastoma, the most common, aggressive brain tumor, ranks among the least curable cancers—owing to its strong tendency for intracranial dissemination, high proliferation potential, and inherent tumor resistance to radiation and chemotherapy. Cur
Externí odkaz:
https://doaj.org/article/8f7fe30df2f64627a8f080769dcc68e4
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1126 (2021)
Elastin-like polypeptides (ELPs) undergo a characteristic phase transition in response to ambient temperature. Therefore, it has been be used as a thermosensitive vector for the delivery of chemotherapy agents since it can be used to target hyperther
Externí odkaz:
https://doaj.org/article/e4506cd96d4846c7b272ba4907829fe9
Publikováno v:
Molecules, Vol 20, Iss 12, Pp 21750-21769 (2015)
The majority of anticancer drugs have poor aqueous solubility, produce adverse effects in healthy tissue, and thus impose major limitations on both clinical efficacy and therapeutic safety of cancer chemotherapy. To help circumvent problems associate
Externí odkaz:
https://doaj.org/article/a2adc084598c45328cb209e70b8184ec
Publikováno v:
Molecules, Vol 24, Iss 18, p 3242 (2019)
To increase treatment efficiency for glioblastoma, we have developed a system to selectively deliver chemotherapeutic doxorubicin (Dox) to Glioblastoma (GBM) tumors. This carrier is based on elastin-like polypeptide (ELP), which is soluble at physiol
Externí odkaz:
https://doaj.org/article/816fb0d2deea4d64a581929d13ee590f
Publikováno v:
Molecules, Vol 14, Iss 6, Pp 1999-2015 (2009)
A well characterized, peptide derivative of bovine lactoferrin, L12, has been shown to possess anticancer properties in multiple cell lines. However, adverse side effects in normal tissues and poor plasma kinetics that hinder the clinical effectivene
Externí odkaz:
https://doaj.org/article/a096c3704d1540a9aad56ad33c58b9f3