Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants

Autor: Stoffel, NU, Uyoga, MA, Mutuku, FM, Frost, JN, Mwasi, E, Paganini, D, van der Klis, FRM, Malhotra, IJ, LaBeaud, AD, Ricci, C, Karanja, S, Drakesmith, H, King, CH, Zimmermann, MB

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 11

Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc7a7a4c41ac50609d7068dd3064fae
https://pubmed.ncbi.nlm.nih.gov/32754150

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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Autor: Pasricha, S., Lim, P., Duarte, T., Casu, C., Oosterhuis, D., Mleczko-Sanecka, K., Suciu, M., Da Silva, A., Al-Hourani, K., Arezes, J., McHugh, K., Gooding, S., Frost, J., Wray, K., Santos, A., Porto, G., Repapi, E., Gray, N., Draper, S., Ashley, N., Soilleux, E., Olinga, P., Muckenthaler, M., Hughes, J., Rivella, S., Milne, T., Armitage, A., Drakesmith, H.

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, 8:403. Nature Publishing Group

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3a577ab42681837e522023a5969b4483

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Erratum: Role of HFE in iron metabolism, hereditary haemochomatosis, anaemia of chronic disease and secondary iron overload (Lancet (March 2) (786))

Autor: Alain Townsend, Drakesmith, H.

Publikováno v: Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9390ab653a731939ae5236654e08e52d
https://ora.ox.ac.uk/objects/uuid:9e6518a5-b66e-44f1-bd15-8c86e4608130