Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Drake M. Mellott"'
Autor:
Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C. Chenna, Drake M. Mellott, Zane W. Taylor, Vivian Tat, Christopher Z. Garcia, Ardala Katzfuss, Chien-Te K. Tseng, Thomas D. Meek
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Externí odkaz:
https://doaj.org/article/83d373bc5b624e3288eb3d76ea8c126b
Autor:
Scott A. Cameron, Lawrence Harris, Arthur Laganowsky, Zahra Moghadamchargari, Dan Torres, James C. Sacchettini, Inna Krieger, Thomas D. Meek, Drake M. Mellott
Publikováno v:
Journal of the American Chemical Society. 143:17666-17676
The isocitrate lyase paralogs of Mycobacterium tuberculosis (ICL1 and 2) are essential for mycobacterial persistence and constitute targets for the development of antituberculosis agents. We report that (2R,3S)-2-hydroxy-3-(nitromethyl)succinic acid
Autor:
Aleksandra Drelich, Miriam A. Giardini, Pavla Fajtová, Drake M. Mellott, Vivian Hook, Thomas D. Meek, Jason C. Hsu, Demetrios H. Kostomiris, Aaron F. Carlin, Frank M. Raushel, Klaudia I. Kocurek, Jair L. Siqueira-Neto, Zane W. Taylor, Anthony J. O’Donoghue, Felix W Frueh, Jiyun Zhu, Ardala Katzfuss, Chien Te K. Tseng, Sungjun Beck, Hong Wang, Brett L. Hurst, Laura Beretta, Ken Hirata, James H. McKerrow, Alex E. Clark, Linfeng Li, Daniel C Maneval, Danielle E. Skinner, Balachandra Chenna, Vivian Tat, Michael C Yoon
Publikováno v:
ACS Chemical Biology. 16:642-650
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SAR
Autor:
Thomas D. Meek, Drake M. Mellott, Truc Viet Pham, Inna Krieger, Zahra Moghadamchargari, Kevin Chen, James C. Sacchettini, Arthur Laganowsky
Publikováno v:
ACS Chemical Biology. 16:463-470
The isocitrate lyases (ICL1/2) are essential enzymes of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. At present, no ICL1/2 inhibitors have progressed to clinical evaluation, despite extensive drug discovery efforts. Herein,
Autor:
Zane W. Taylor, Marcetta Y. Darensbourg, Drake M. Mellott, Thomas D. Meek, Christopher R DeLaney, Ardala Katzfuss, Jiyun Zhu, D Chase Pectol
Publikováno v:
Chemical Communications. 57:8352-8355
By repurposing DNICs designed for other medicinal purposes, the possibility of protease inhibition was investigated in silico using AutoDock 4.2.6 (AD4) and in vitro via a FRET protease assay. AD4 was validated as a predictive computational tool for
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff
Autor:
Drake M, Mellott, Dan, Torres, Inna V, Krieger, Scott A, Cameron, Zahra, Moghadamchargari, Arthur, Laganowsky, James C, Sacchettini, Thomas D, Meek, Lawrence D, Harris
Publikováno v:
Journal of the American Chemical Society. 143(42)
The isocitrate lyase paralogs of
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Autor:
Truc Viet, Pham, Drake M, Mellott, Zahra, Moghadamchargari, Kevin, Chen, Inna, Krieger, Arthur, Laganowsky, James C, Sacchettini, Thomas D, Meek
Publikováno v:
ACS chemical biology. 16(3)
The isocitrate lyases (ICL1/2) are essential enzymes of
Autor:
Ken Hirata, Sungjun Beck, Hong Wang, Tat, Pavla Fajtová, Balachandra Chenna, Daniel C Maneval, Brett L. Hurst, Hsu J, Thomas D. Meek, Ardala Katzfuss, Anthony J. O’Donoghue, Frank M. Raushel, Li Li, Chien-Te K Tseng, Klaudia I. Kocurek, Kostomiris Dh, Aaron F. Carlin, Danielle E. Skinner, Felix W Frueh, Miriam A. Giardini, Jiyun Zhu, Zane W. Taylor, Aleksandra Drelich, Drake M. Mellott, de Siqueira-Neto Jl, Laura Beretta, James H. McKerrow, Alex E. Clark
Publikováno v:
bioRxiv
ACS Chemical Biology
article-version (status) pre
article-version (number) 2
ACS Chemical Biology
article-version (status) pre
article-version (number) 2
K777 is a di-peptide analog that contains an electrophilic vinyl-sulfone moiety and is a potent, covalent inactivator of cathepsins. Vero E6, HeLa/ACE2, Caco-2, A549/ACE2, and Calu-3, cells were exposed to SARS-CoV-2, and then treated with K777. K777
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e9f9624831d65f564f679a6c488aa4
https://europepmc.org/articles/PMC7605553/
https://europepmc.org/articles/PMC7605553/