Výsledky vyhledávání - "Drake Eggleston"

Chiral high-performance liquid chromatography of some related bicyclic lactams

Autor: Carlo Farina, Jose A. Murphy, Drake Eggleston, Mario Pinza, Lesley A. Senior, Ugo Pfeiffer, Patrick Camilleri

Publikováno v: Journal of Chromatography A. 654:207-213

Chromatographic methods utilising a Chiralcel OC cellulose-based column were developed for the chiral resolution of optical isomers of the cognition-enhancing ISF 4185 and related bicyclic lactams. These methods were scaled up for the preparation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d764afb17bb6a5f203e6bc5e159ad381
https://doi.org/10.1016/0021-9673(93)83363-w

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ChemInform Abstract: Intermolecular Interactions Responsible for the Absence of Chiral Recognition: Aromatic C-H×××O Hydrogen Bonding in the Crystal Structure of 3-Chloro-9,13-dibutylamino-1-hydroxypropyl-6- trifluomethylphenanthrene Propan-2-ol Solvate H

Autor: Patrick Camilleri, Michael L. Webb, Drake Eggleston, Henry Rzepa

Publikováno v: ChemInform. 25

Both the 3-Cl and the more remote 6-CF3 groups in 1-dechlorohalofantrine 3 promote strong edge-to-edge aromatic O ⋯ H(1)–C interactions, similar to those found in thiamine picrate 6, which we suggest inhibit the resolution of 3 on chiral HPLC col

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88d061ce94408b0941e71311d85b1394
https://doi.org/10.1002/chin.199439041

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Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors

Autor: Murray J. B. Brown, Karen O'Dwyer, Drake Eggleston, Simon A. Readshaw, Stephen Ashman, Lei Wang, Andrew West, Gordon Bruton, Andrew J. Pope, Keith J. Moore, John Humphries, Peter J. O'Hanlon, Anthony Huxley, Barry Sidney Orlek

Publikováno v: European journal of medicinal chemistry. 38(4)

Pre-protein sequence data was used to design substrates for SpsB, the bacterial signal peptidase I enzyme from Staphylococcus aureus. Key elements were an alkyl membrane anchor, proline at P5 and lysine at P2. The proline at P5 induced a helical turn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd185f8121129e69a6ed34d94f96dc72
https://pubmed.ncbi.nlm.nih.gov/12750021

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Intermolecular interactions responsible for the absence of chiral recognition: aromatic C–H ⋯ O hydrogen bonding in the crystal structure of 3-chloro-9,13-dibutylamino-1-hydroxypropyl-6-trifluomethylphenanthrene propan-2-ol solvate hydrochloride

Autor: Michael L. Webb, Drake Eggleston, Henry Rzepa, Patrick Camilleri

Publikováno v: J. Chem. Soc., Chem. Commun.. :1135-1137

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c996d1ab54f84c706d072048ffde0ca8
https://doi.org/10.1039/c39940001135

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