Minor intron splicing is critical for survival of lethal prostate cancer

Autor: Augspach, Anke, Drake, Kyle D., Roma, Luca, Qian, Ellen, Lee, Se Ri, Clarke, Declan, Kumar, Sushant, Jaquet, Muriel, Gallon, John, Bolis, Marco, Triscott, Joanna, Galván, José A., Chen, Yu, Thalmann, George N., Kruithof-de Julio, Marianna, Theurillat, Jean-Philippe P., Wuchty, Stefan, Gerstein, Mark, Piscuoglio, Salvatore, Kanadia, Rahul N., Rubin, Mark A.

Publikováno v: In Molecular Cell 15 June 2023 83(12):1983-2002

Minor intron splicing is critical for survival of lethal prostate cancer

Autor: Augspach, Anke Katharina, Drake, Kyle D, Roma, Luca, Qian, Ellen, Lee, Se Ri, Clarke, Declan, Kumar, Sushant, Jaquet, Muriel, Gallon, John, Bolis, Marco, Triscott, Joanna Catherine Caprio, Galván, José A, Chen, Yu, Thalmann, George N, Kruithof-de Julio, Marianna, Theurillat, Jean-Philippe P, Wuchty, Stefan, Gerstein, Mark, Piscuoglio, Salvatore, Kanadia, Rahul N, Rubin, Mark A

Publikováno v: Augspach, Anke Katharina; Drake, Kyle D; Roma, Luca; Qian, Ellen; Lee, Se Ri; Clarke, Declan; Kumar, Sushant; Jaquet, Muriel; Gallon, John; Bolis, Marco; Triscott, Joanna Catherine Caprio; Galván, José A; Chen, Yu; Thalmann, George N; Kruithof-de Julio, Marianna; Theurillat, Jean-Philippe P; Wuchty, Stefan; Gerstein, Mark; Piscuoglio, Salvatore; Kanadia, Rahul N; ... (2023). Minor intron splicing is critical for survival of lethal prostate cancer. Molecular cell, 83(12), 1983-2002.e11. Cell Press 10.1016/j.molcel.2023.05.017

The evolutionarily conserved minor spliceosome (MiS) is required for protein expression of ∼714 minor intron-containing genes (MIGs) crucial for cell-cycle regulation, DNA repair, and MAP-kinase signaling. We explored the role of MIGs and MiS in ca

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